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Optimization of Chelation Process for Complex Microelement iron supplement Derived from Pig Blood by Response Surface Methodology

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Agricultural Biotechnology 2019年第1期8卷 235-240页

作者： Jingjing HUANG Yan YAN Fusheng ZHANG Junfeng YIN Yingqin ZHOU Ningning XIE Institute of Agricultural Products Processing Anhui Academy of Agricultural Sciences

[Objectives]This study aimed to optimize the chelation process for complex microelement iron supplement derived from pig blood by response surface methodology.[Methods]On the basis of single-factor test,p H value,concentration of polypeptide solution and volume ratio of polypeptide solution to FeCl_2 solution were selected as influencing factors with Fe(II)chelation rate as the indicator for Box-Behnken central composite experimental design with three factors and three *** effects of three factors on the response value were analyzed by response surface methodology.[Results]The optimized chelation process for complex microelement iron supplement derived from pig blood by response surface methodology was as follows:pH 5.40,polypeptide solution concentration 2.27%,volume ratio of polypeptide solution to FeCl_2 solution 2.16∶*** this condition,the predictive Fe(II)chelation rate of iron supplement was 79.37%,while the actual value was 79.41%.[Conclusions]The optimized process may provide new thoughts for the development and utilization of complex microelement iron supplement derived from pig blood.

关键词： Response surface methodology Pig blood protein iron supplement Fe(Ⅱ) chelation rate

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Effect and Safety of iron supplementation on Mild Thalassemia Complicated by iron Deficiency in Late Pregnancy

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Journal of Clinical and Nursing Research 2021年第6期5卷 15-18页

作者： Yanchuan Li Yanfeng Liu Xue Li Limin Hou Shaanxi Provincial People’s Hospital Xi’an 710068Shaanxi ProvinceChina The Second Affiliated Hospital of Xi’an Medical College Xi’an 710038Shaanxi ProvinceChina

Aim:To study the clinical effect and safety of iron supplementation in the treatment of mild thalassemia complicated by iron deficiency in late ***:376 patients with mild thalassemia complicated by iron deficiency in late pregnancy treated in our hospital from July 2019 to June 2021 were selected and recruited in the research group,and 200 normal pregnant women treated in the same period were selected and recruited in the control ***(Hb),reticulocyte blood,red blood protein(RET he)level,ferritin(SF)level,soluble transferrin receptor(sTfR)level,adverse maternal and infant outcomes,*** ***:There was no significant difference in the levels of SF,Hb,RET he and sTfR between the two groups before *** treatment,the levels of SF,Hb,RET he and sTfR in the research group were significantly improved,which was statistically significant compared with the control *** frequencies of intrapartum hemorrhage,premature delivery,stillbirth,hemorrhagic shock,and neonatal asphyxia in the research group were 289±47.88,36(9.57%),0(0.00%),25(6.65%),and 6(1.26%),*** frequencies of intrapartum hemorrhage,premature delivery,stillbirth,hemorrhagic shock,and neonatal asphyxia in the control group were 284±46.99,7(3.50%),0(0.00%),6(3.00%),and 0(0.00%),*** were significant differences in preterm delivery and hemorrhagic shock,and there was no significant difference in other delivery ***:Under the premise of strictly controlling the iron reserve in pregnant women,continuous medication until the end of delivery may be conducive to the control of maternal thalassemia complicated by iron deficiency and the improvement of pregnancy outcome.

关键词： iron supplement Late pregnancy Mild thalassemia

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Flammulina velutipes polysaccharide-iron (Ⅲ) complex used to treat iron deficiency anemia after being absorbed via GLUT2 and SGLT1 transporters

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Food Science and Human Wellness 2023年第5期12卷 1828-1840页

作者： Chenying Shi Chen Cheng Xiaotong Lin Yanfang Qian Yufeng Du Guitang Chen Department of Food Nutrition and Safety/National R&D Center for Chinese Herbal Medicine Processing China Pharmaceutical UniversityNanjing 211198China College of Pharmacy China Pharmaceutical UniversityNanjing 211198China

iron deficiency anemia(IDA)is a common nutritional problem, but traditional iron supplements cause many adverse reactions. Thus, the development of a novel iron supplement might be significant for the treatment of IDA. This study aimed to study the transport mechanism of Flammulina velutipes polysaccharide-iron complex(FVP1-Fe(Ⅲ))in Caco-2 cells and the therapeutic effect on IDA rats, as well as the influence on gut microbiota in vivo. These results showed that in vitro, the uptake of FVP1-Fe(Ⅲ)was mediated by sodium-dependent glucose transporter-1(SGLT1)and facilitated glucose transporter-2(GLUT2)and GLUT2 played a dominant function. The multidrug resistance-associated protein-2(MRP-2)was involved in the efflux of FVP1-Fe(Ⅲ)across the Caco-2 cells. In vivo, FVP1-Fe(Ⅲ)had a better restorative effect on blood parameters and iron status indicators in rats with IDA as compared with FeSO_4 and exerted this effect by downregulating the expression of hepcidin. FVP1-Fe(Ⅲ)could also regulate gut microbiota dysbiosis in iron deficiency rats by returning the relative abundance of gut microbiota to the normal level. Besides, as a dietary factor, vitamin C(vit C)could enhance the therapeutic effect of FVP1-Fe(Ⅲ). These present findings showed that FVP1-Fe(Ⅲ)could be exploited as a novel iron supplement to treat IDA.

关键词： Flammulina velutipes polysaccharide iron deficiency anemia iron supplement Caco-2 cell model Gut microbiota

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