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Association Between IL-6 （Interleukin-6） and iron status in Rheumatoid Arthritis Patients

Journal of Life Sciences 2014年第5期8卷 404-409页

作者： Abbas Sabbar Dkhil Musa Nima Mezher Physiology Department Faculty of Medicine University of Qadisiyah Qadisiyah 58002 Iraq Biology Department Faculty of Science University of Kufa Najaf Qadisiyah 58002 Iraq

The study was performed to determine whether the srum concentrations of IL （interleukin）-6 are elevated in patients with RA （rheumatoid arthritis） and to investigate the relationship between IL-6 levels and iron status in RA patients. 95 serum samples were obtained, 70 of them from patients with RA who had visited the department of Rheumatology at Al-Sadder medical city in Najaf governorate （Iraq） and 25 age and sex-matched healthy controls. The authors assessed the clinical parameters of the disease, including ESR （erythrocyte sedimentation rate）, CRP （C-reactive protein）, and RF （rheumatoid factor）. Serum levels of iron and TIBC （total iron binding capacity） were measured spectrophotometrically, while TS% （transferrin saturation percentage） and transferrin concentration were calculated mathematically. Serum concentrations of IL-6 （interleukin-6） and ferritin were measured using an ELISA （enzyme-linked immunosorbent assay）. The results of serum concentration of IL-6 （interleukin-6） and ferritin were significantly elevated （P 〈 0.0001） in patients with RA compared to those of healthy controls. On the other hand, serum concentrations of iron, TIBC （total iron binding capacity）, TS% （transferrin saturation percentage） and transferrin concentration were significantly decreased in patients with RA compared with those of healthy controls. These findings suggest that anemia is the most frequent observations in patients with RA and mostly associative with increasing level of interleukin-6.

关键词： Rheumatoid arthritis interleukin-6 iron status ACD (anemia of chronic diseases) proinflammatory cytokines.

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Contribution of iron status at birth to infant iron status at 9 months

Contribution of iron status at birth to infant iron status a...

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2017浙江省营养学会年会暨西湖营养学术论坛

作者：朱冰泉 Blair Richards Niko Kaciroti Katy M.Clark Zhengyan Zhao Jie Shao Betsy Lozoff Children's Hospital Zhejiang University School of Medicine Center for Human Growth and Development University of Michigan Department of Pediatrics and Communicable Diseases University of Michigan

BACKGROUND/OBJECTIVE:A physiologic framework indicates that infant iron status will be determined by the iron the infant is born with and postnatal iron needs,availability,and *** previous studies did not assess iron status at *** used the framework to consider multiple measures of iron status at birth in assessing predictors of iron status at 9 ***/METHODS:Hemoglobin(Hb),serum ferritin(SF),serum transferrin receptor(sTfR),and zinc protoporphyrin/heme(ZPP/H) were measured in cord blood and venous blood at 9 months for545 healthy term Chinese infants,along with mean cell volume(MCV) and red cell distribution width(RDW) at 9 *** deficiency(ID) at 9 months was defined as ≥2 abnormal iron measures,iron deficiency anemia(IDA) as ID+anemia(Hbiron composite and calculated body iron based on SF and *** applied structural equation modeling to assess predictors of 9-month iron status and used logistic regression to calculate odds ratios(OR) for ID,IDA,and ***:At 9 months,34.7%of infants had ID overall(19.6%IDA).Higher cord ZPP/H and sTfR,lower Hb,lower birth weight,male sex,older age at testing,higher weight,and breastfeeding predicted poorer 9-month iron composite;cord ZPP/H,birth weight,sex,age,and feeding predicted body *** was the strongest single *** to formula-fed infants,the odds of IDA were19.1 and 3.6 times higher in breastfed and mixed-fed infants,***:The study showed that indicators of iron status at birth,postnatal iron needs,and external iron sources independently predicted iron status at 9 *** was an additional predictor.

关键词： iron deficiency cord blood iron status sex differences infant feeding infants China

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Source and level of dietary iron influence semen quality by affecting inflammation, oxidative stress and iron utilization levels in boars

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2044-2058页

作者： Yinghui Wu Yamei Li Yueyue Miao Hongkui Wei Hefeng Luo Chunxiao Ren Yawei Zhang Juan Chen Tanghong Wei Jiyan Deng Jian Peng Department of Animal Nutrition and Feed Science College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China The Cooperative Innovation Center for Sustainable Pig Production Wuhan 400700China Frontiers Science Center for Animal Breeding and Sustainable Production Wuhan 430070China Dekon Food and Agriculture Group Chengdu 610000China Xingjia Bio-Engineering Co.Ltd Changsha 410011China

Background Boars fed a mixed form of inorganic and organic iron in excess of the NRC recommended levels still develop anemia,which suggested that the current level and form of iron supplementation in boar diets may be ***,56 healthy Topeka E line boars aged 15–21 months were randomly divided into 5 groups:basal diet supplemented with 96 mg/kg ferrous sulfate(FeSO_(4))and 54 mg/kg glycine chelated iron(Gly-Fe,control);80 mg/kg or 115 mg/kg Gly-Fe;80 mg/kg or 115 mg/kg methionine hydroxyl analogue chelated iron(MHA-Fe,from CalimetFe)for 16 *** effects of dietary iron supplementation with different sources and levels on semen quality in boars were *** 1)Serum Fe and hemoglobin concentrations were not affected by reduced dietary iron levels in the 80 mg/kg or 115 mg/kg Gly-Fe and MHA-Fe groups compared with the control group(P>0.05).2)Serum interleukin-6(IL-6)and sperm malondialdehyde(MDA)levels in the 80 mg/kg or 115 mg/kg MHA-Fe groups were lower than those in the control group(Piron status and oxidative stress and semen quality ***

关键词： Adult boars iron level iron source iron status Semen quality

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Serum Hepcidin Predicts Uremic Accelerated Atherosclerosis in Chronic Hemodialysis Patients with Diabetic Nephropathy

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Chinese Medical Journal 2015年第10期128卷 1351-1357页

作者： Han Li Su-Juan Feng Lu-Lu Su Wei Wang Xiao-Dong Zhang Shi-Xiang Wang Department of Blood Purification Beijing Chao-Yang Hospital Capital Medical University Nephrology Faculty Capital Medical University Beiina 100020 China Institute of Uro-Nephrology Beijing Chao-Yang-Hospital Capital Medical University Beijing 100020 China

Background：Hepcidin,as a regulator of body iron stores,has been recently discovered to play a critical role in the pathogenesis of anemia of chronic *** cardiovascular disease is the most common complication and the leading cause of death in chronic hemodialysis （CHD） *** the current study,we aimed to explore the relationship between serum hepcidin and uremic accelerated atherosclerosis （UAAS） in CHD patients with diabetic nephropathy （CHD/DN）.Methods：A total of 78 CHD/DN and 86 chronic hemodialyzed nondiabetic patients with chronic glomerulonephritis （CHD/non-DN） were recruited in this *** level of serum hepcidin-25 was specifically measured by liquid chromatography-tandem mass *** levels of interleukin-6 （IL-6） and tumor necrosis factor-α （TNF-α） were measured by enzyme-linked immunosorbent ***：High serum level ofhepcidin-25 was seen in CHD *** hepcidin-25 in CHD/DN was significantly higher than that in CHD/non-DN *** hepcidin-25 was positively correlated with ferritin,high-sensitivity C-reactive protein （hs-CRP）,TNF-α,and IL-6 in CHD/DN ***/DN patients exhibited higher common carotid artery intima media thickness （CCA-IMT）,hs-CRP,and hepcidin-25 levels than that in CHD/non-DN ***,in CHD/DN patients,CCA-IMT was positively correlated with serum hepcidin,hs-CRP,and low-density *** multiple regression analysis,serum hepcidin and hs-CRP level exhibited independent association with IMT in CHD/DN ***：These findings suggest possible linkage between iron metabolism and hepcidin modulation abnormalities that may contribute to the development of UAAS in CHD/DN patients.

关键词： Atherosclerosis Hemodialysis Hepcidin iron status

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