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iron accumulation and its impact on osteoporotic fractures in postmenopausal women

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第4期24卷 301-311页

作者： Hui CAI Huimei ZHANG Weiting HE Heng ZHANG Department of Pharmacy the First Affiliated Hospital of Bengbu Medical CollegeBengbu Medical CollegeBengbu 233004China School of Pharmacy Bengbu Medical CollegeBengbu 233030China School of Clinical Medicine Bengbu Medical CollegeBengbu 233030China Department of Orthopedics the First Affiliated Hospital of Bengbu Medical CollegeLaboratory of Tissue and Transplant in Anhui ProvinceBengbu Medical CollegeBengbu 233004China Department of Orthopedics Jinling HospitalSchool of MedicineNanjing UniversityNanjing 210002China

Postmenopausal osteoporosis is a kind of degenerative disease,also described as“invisible killer.”Estrogen is generally considered as the key hormone for women to maintain bone mineral content during their *** accumulation refers to a state of human serum ferritin that is higher than the normal value but less than 1000μg/*** has been found that iron accumulation and osteoporosis could occur simultaneously with the decrease in estrogen level after *** recent years,many studies indicated that iron accumulation plays a vital role in postmenopausal osteoporosis,and a significant correlation has been found between iron accumulation and fragility *** this review,we summarize and analyze the relevant literature including randomized controlled trials,systematic reviews,and meta-analyses between January 1996 and July *** investigate the mechanism of the effect of iron accumulation on bone metabolism and discuss the relationship of iron accumulation,osteoporosis,and postmenopausal fragility fractures,as well as the main clinical treatment *** conclude that it is necessary to pay attention to the phenomenon of iron accumulation in postmenopausal women with osteoporosis and explore the in-depth mechanism of abnormal bone metabolism caused by iron accumulation,in order to facilitate the discovery of effective therapeutic targets for postmenopausal osteoporosis.

关键词： iron accumulation Postmenopausal osteoporosis Bone metabolism Osteoporotic fracture

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Bone Microthrombus Promotes Bone Loss in iron accumulation Rats

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Current Medical Science 2020年第5期40卷 943-950页

作者： Hai-feng HANG Long-jia DONG Xin-bing TANG Ai-fei WANG Fan YANG Hui ZHANG You-jia XU Department of Orthopedics Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Department of Orthopedics The Affiliated Baiyun Hospital of Guizhou Medical UniversityGuizhou 550014China Osteoporosis Institute Soochow UniversitySuzhou 215004China Department of Orhopedics Jiangdu People's Hospital of YangzhouYangzhou 225200China

In the present study,we investigated the changes of the coagulation state,bone microthrombus,microvascular bed and bone density levels in iron accumulation ***,the effect of anticoagulation therapy on bone mineral density was further *** established two groups:a control(Ctrl)group and an iron intervention(FAC)*** in coagulation function,peripheral blood cell counts,bone microthrombus,bone vessels and bone mineral density were compared between the two *** designed the non-treatment group and treatment group to study the changes of bone mineral density by preventing microthrombus formation with the anticoagulant *** found that the fbrinogen and D-dimer contents were significantly higher,whereas the thrombin time(TT)and prothrombin time(PT)were significantly shorter in the FAC *** ink staining,the microvascular bed in the FAC group was significantly reduced compared with that in the Ctrl *** and Martius Scarlet Blue(MSB)staining showed microthrombus in the bone marrow of the iron accumulation *** anticoagulation therapy,the bone microcirculation vascular bed areas in the treatment group rats were significantly ***,the bone mineral density was increased in the treatment group compared with that in the non-treatment *** experiments,we found that the blood in iron accumulation rat was relatively hypercoagulable;moreover,there was microthrombus in the bone marrow,and the bone vascular bed was ***,anticoagulation was helpful for improving bone microcirculation,reducing microthrombus and decreasing bone loss.

关键词： iron accumulation osteoporosis coagulation state microvascular bed bone microthrombus anticoagulant

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Correction to“Inhibiting heme oxygenase-1 attenuates rat liver fibrosis by removing iron accumulation”

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World Journal of Gastroenterology 2022年第35期28卷 5237-5239页

作者： Qiu-Ming Wang Jian-Ling Du Zhi-Jun Duan Shi-Bin Guo Xiao-Yu Sun Zhen Liu Department of Gastroenterology The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Department of Endocrinology The First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

We found a mistake in Figure 6. Panels A (Sham group) and F (DFX group) (180degrees rotated) is same images. We have replaced the incorrect images (Panels F)with the correct Figure. This error does not change the meaning of the picture orthe conclusion of the manuscript. We apologize for our unintentional mistakes,which caused great inconvenience.

关键词： Heme oxygenase-1 Hepcidin iron accumulation Oxidative stress Portal vein pressure Carboxyhemoglobin Bile duct ligation

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OsARF12,a transcription activator on auxin response gene,regulates root elongation and affects iron accumulation in rice(Oryza sativa L.)

OsARF12,a transcription activator on auxin response gene,reg...

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2011全国植物生物学研讨会

作者： SuiKang Wang,ChenJia Shen,SaiNa Zhang,Yue Chen,YanXia Xu,Yu Liu, YunRong Wu,DeAn Jiang,YanHua Qi State Key Laboratory of Plant Physiology and Biochemistry,College of Life Sciences,Zhejiang University,Hangzhou 310058,China

Auxin has an important role in maintaining optimal root system architecture(RSA) that can cope with growth reductions of crops caused by water or nutrient ***,the mechanism of controlling RSA remains largely ***,we found a limiting factor of RSA - OsARF12 - an auxin response factor whose knockout led to decreased primary root length in rice (Oryza sativa L.). OsARF 12 as a transcription activator can facilitate the expression of the

关键词： auxin response gene iron accumulation OsARF12 rice root elongation transcription activator

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Filamentous morphology engineering of bacteria by iron metabolism modulation through MagR expression

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Synthetic and Systems Biotechnology 2024年第3期9卷 522-530页

作者： Mengke Wei Chenyang Han Xiujuan Zhou Tianyang Tong Jing Zhang Xinmiao Ji Peng Zhang Yanqi Zhang Yan Liu Xin Zhang Tiantian Cai Can Xie Institutes of Physical Science and Information Technology Anhui UniversityHefeiAnhui230039China High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of SciencesScience IslandHefeiAnhui230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefeiAnhui230036China Department of Anatomy Anhui Medical UniversityHefeiAnhui230032China Institute of Quantum Sensing Zhejiang UniversityHangzhouZhejiang310027China

The morphology is the consequence of evolution and *** coli is rod-shaped bacillus with regular dimension of about 1.5μm long and 0.5μm *** shape-related genes have been identified and used in morphology engineering of this ***,little is known about if specific metabolism and metal irons could modulate bacteria *** in this study,we discovered filamentous shape change of *** cells overexpressing pigeon MagR,a putative magnetoreceptor and extremely conserved iron-sulfur *** transcriptomic analysis strongly suggested that the iron metabolism change and iron accumulation due to the overproduction of MagR was the key to the morphological *** model was further validated,and filamentous morphological change was also achieved by supplement *** cells with iron in culture medium or by increase the iron uptake genes such as entB and *** study extended our understanding of morphology regulation of bacteria,and may also serves as a prototype of morphology engineering by modulating the iron metabolism.

关键词： Morphology regulation iron accumulation Filamentous bacteria MagR overexpression

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