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2017浙江省营养学会年会暨西湖营养学术论坛

作者：朱冰泉 Blair Richards Niko Kaciroti Katy M.Clark Zhengyan Zhao Jie Shao Betsy Lozoff Children's Hospital Zhejiang University School of Medicine Center for Human Growth and Development University of Michigan Department of Pediatrics and Communicable Diseases University of Michigan

BACKGROUND/OBJECTIVE:A physiologic framework indicates that infant iron status will be determined by the iron the infant is born with and postnatal iron needs,availability,and *** previous studies did not assess iron status at *** used the framework to consider multiple measures of iron status at birth in assessing predictors of iron status at 9 ***/METHODS:Hemoglobin(Hb),serum ferritin(SF),serum transferrin receptor(sTfR),and zinc protoporphyrin/heme(ZPP/H) were measured in cord blood and venous blood at 9 months for545 healthy term Chinese infants,along with mean cell volume(MCV) and red cell distribution width(RDW) at 9 *** deficiency(ID) at 9 months was defined as ≥2 abnormal iron measures,iron deficiency anemia(IDA) as ID+anemia(Hbiron composite and calculated body iron based on SF and *** applied structural equation modeling to assess predictors of 9-month iron status and used logistic regression to calculate odds ratios(OR) for ID,IDA,and ***:At 9 months,34.7%of infants had ID overall(19.6%IDA).Higher cord ZPP/H and sTfR,lower Hb,lower birth weight,male sex,older age at testing,higher weight,and breastfeeding predicted poorer 9-month iron composite;cord ZPP/H,birth weight,sex,age,and feeding predicted body *** was the strongest single *** to formula-fed infants,the odds of IDA were19.1 and 3.6 times higher in breastfed and mixed-fed infants,***:The study showed that indicators of iron status at birth,postnatal iron needs,and external iron sources independently predicted iron status at 9 *** was an additional predictor.

关键词： iron deficiency cord blood iron status sex differences infant feeding infants China

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Serum Hepcidin Predicts Uremic Accelerated Atherosclerosis in Chronic Hemodialysis Patients with Diabetic Nephropathy

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Chinese Medical Journal 2015年第10期128卷 1351-1357页

作者： Han Li Su-Juan Feng Lu-Lu Su Wei Wang Xiao-Dong Zhang Shi-Xiang Wang Department of Blood Purification Beijing Chao-Yang Hospital Capital Medical University Nephrology Faculty Capital Medical University Beiina 100020 China Institute of Uro-Nephrology Beijing Chao-Yang-Hospital Capital Medical University Beijing 100020 China

Background：Hepcidin,as a regulator of body iron stores,has been recently discovered to play a critical role in the pathogenesis of anemia of chronic *** cardiovascular disease is the most common complication and the leading cause of death in chronic hemodialysis （CHD） *** the current study,we aimed to explore the relationship between serum hepcidin and uremic accelerated atherosclerosis （UAAS） in CHD patients with diabetic nephropathy （CHD/DN）.Methods：A total of 78 CHD/DN and 86 chronic hemodialyzed nondiabetic patients with chronic glomerulonephritis （CHD/non-DN） were recruited in this *** level of serum hepcidin-25 was specifically measured by liquid chromatography-tandem mass *** levels of interleukin-6 （IL-6） and tumor necrosis factor-α （TNF-α） were measured by enzyme-linked immunosorbent ***：High serum level ofhepcidin-25 was seen in CHD *** hepcidin-25 in CHD/DN was significantly higher than that in CHD/non-DN *** hepcidin-25 was positively correlated with ferritin,high-sensitivity C-reactive protein （hs-CRP）,TNF-α,and IL-6 in CHD/DN ***/DN patients exhibited higher common carotid artery intima media thickness （CCA-IMT）,hs-CRP,and hepcidin-25 levels than that in CHD/non-DN ***,in CHD/DN patients,CCA-IMT was positively correlated with serum hepcidin,hs-CRP,and low-density *** multiple regression analysis,serum hepcidin and hs-CRP level exhibited independent association with IMT in CHD/DN ***：These findings suggest possible linkage between iron metabolism and hepcidin modulation abnormalities that may contribute to the development of UAAS in CHD/DN patients.

关键词： Atherosclerosis Hemodialysis Hepcidin iron status

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