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Spectral computed tomography in advanced gastric cancer: Can iodine concentration non-invasively assess angiogenesis?

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World Journal of Gastroenterology 2017年第9期23卷 1666-1675页

作者： Xiao-Hua Chen Ke Ren Pan Liang Yaru Chai Kui-Sheng Chen Jian-Bo Gao Department of Radiology The First Affiliated Hospital of Zhengzhou University Surgery of Gastroenterology Luohe Central Hospital Department of Pathology The First Affiliated Hospital of Zhengzhou University

AIM To investigate the correlation of iodine concentration(IC) generated by spectral computed tomography(CT) with micro-vessel density(MVD) and vascular endothelial growth factor(VEGF) expression in patients with advanced gastric carcinoma(GC).METHODS Thirty-four advanced GC patients underwent abdominal enhanced CT in the gemstone spectral imaging mode. The IC of the primary lesion in the arterial phase(AP) and venous phase(VP) were measured, and were then normalized against that in the aorta to provide the normalized IC(nI C). MVD and VEGF were detected by immunohistochemical assays, using CD34 and VEGF-A antibodies, respectively. Correlations of nI C with MVD, VEGF, and clinical-pathological features were *** Both nI Cs correlated linearly with MVD and were higher in the primary lesion site than in the normal control site, but were not correlated with VEGF expression. After stratification by clinical-pathological subtypes, nI C-AP showed a statistically significant correlation with MVD, particularly in the group with tumors at stage T4, without nodular involvement, of a mixed Lauren type, where the tumor was located at the antrum site, and occurred in female individuals. nI C-VP showed a positive correlation with MVD in the group with the tumor at stage T4 and above, had nodular involvement, was poorly differentiated, was located at the pylorus site, of a mixed and diffused Lauren subtype, and occurred in male individuals. nI C-AP and nI C-VP showed significant differences in terms of histological differentiation and Lauren *** The IC detected by spectral CT correlated with the MVD. n IC-AP and n IC-VP can reflect angiogenesis in different pathological subgroups of advanced GC.

关键词： Micro-vessel density iodine concentration Spectral computed tomography Vascular endothelial growth factor Gastric cancer

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Quantitative parameters in novel spectral computed tomography:Assessment of Ki-67 expression in patients with gastric adenocarcinoma

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World Journal of Gastroenterology 2023年第10期29卷 1602-1613页

作者： Li-Ting Mao Wei-Cui Chen Jian-Ye Lu Han-Liang Zhang Yong-Song Ye Yu Zhang Bo Liu Wei-Wei Deng Xian Liu Department of Radiology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Pathology The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510120Guangdong ProvinceChina Department of Scientific Research Clinical&Technical SupportPhilips Healthcare ChinaShanghai 200040China

BACKGROUND The level of Ki-67 expression has served as a prognostic factor in gastric *** quantitative parameters based on the novel dual-layer spectral detector computed tomography(DLSDCT)in discriminating the Ki-67 expression status are *** To investigate the diagnostic ability of DLSDCT-derived parameters for Ki-67 expression status in gastric carcinoma(GC).METHODS Dual-phase enhanced abdominal DLSDCT was performed preoperatively in 108 patients with gastric *** tumor monoenergetic CT attenuation value at 40-100 kilo electron volt(kev),the slope of the spectral curve(λ_(HU)),iodine concentration(IC),normalized IC(nIC),effective atomic number(Z^(eff))and normalized Z^(eff)(nZ^(eff))in the arterial phase(AP)and venous phase(VP)were retrospectively compared between patients with low and high Ki-67 expression in gastric ***’s correlation coefficient was used to analyze the association between the above parameters and Ki-67 expression *** operating characteristic(ROC)curve analysis was performed to compare the diagnostic efficacy of the statistically significant parameters between two *** Thirty-seven and 71 patients were classified as having low and high Ki-67 expression,***_(40 kev-VP),CT_(70 kev-VP),CT_(100 kev-VP),and Z^(eff)-related parameters were significantly higher,but IC-related parameters were lower in the group with low Ki-67 expression status than the group with high Ki-67 expression status,and other analyzed parameters showed no statistical difference between the two ***’s correlation analysis showed that CT_(40 kev-VP),CT_(70 kev-VP),CT_(100 kev-VP),Z^(eff),and n Z^(eff) exhibited a negative correlation with Ki-67 status,whereas IC and nIC had positive correlation with Ki-67 *** ROC analysis demonstrated that the multi-variable model of spectral parameters performed well in identifying the Ki-67 status[area under the curve(AUC)=0.967;sensitivity 9

关键词： Spectral computer tomography Quantitative parameters Gastric carcinoma iodine concentration Effective atomic number Ki-67 expression

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Diagnostic Value of Dual-Energy CT in Differentiating Malignant and Benign Thyroid Nodules: A Systematic Review and Meta-Analysis

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Journal of Biosciences and Medicines 2021年第4期9卷 54-76页

作者： Kunlin Ye Yongyao Kuang Jianye Liang Xi Xu Changzheng Shi Qingqing Cheng Zijie Jiang Ziyun Xiang Liangping Luo Department of Medical Imaging Center The First Affiliated Hospital of Jinan University Guangzhou China Department of Medical Imaging Longgang District People’s Hospital of Shenzhen Shenzhen China Department of Medical Imaging Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China

Objectives: To evaluate the diagnostic performance of the quantitative iodine parameters, including iodine concentration (IC), Normalized iodine concentration (NIC), and λHU, in distinguishing malignant and benign thyroid nodules. Methods: Relevant studies were searched from Web of Science, PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure database and other complementary sources from inception to May 20, 2020. Study selection, data extraction, quality assessment, and data analyses were performed following the Cochrane standards and the PRISMA-DTA guideline. Results: Eight studies were included (595 patients with 737 thyroid nodules). The pooled sensitivity, specificity and summary diagnostic odds ratio of IC were 79% (95% CI: 69% - 86%), 76% (95% CI: 65% - 84%) and 11 (95% CI: 5 - 27) respectively;those of NIC were 78% (95% CI: 70% - 85%), 80% (95% CI: 74% - 85%) and 15 (95% CI: 9 - 24) respectively;those of λHU were 80% (95% CI: 71% - 87%), 77% (95% CI: 70% - 83%) and 14 (95% CI: 8 - 24) respectively. Conclusion: DECT can be a potential evaluation tool for thyroid nodules. The NIC may be the most sensitive iodine parameter and could be comparable between different DECT machines in thyroid nodule assessment.

关键词： Thyroid Nodules Differential Diagnosis Dual-Energy CT iodine concentration Meta-Analysis

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