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Real-world insights for the evolving intervention strategy for non-mild acute pancreatitis:35-year experience in a Chinese Tertiary Center

引用

Journal of Pancreatology 2024年第2期7卷 111-118页

作者： Xiaxiao Yan Jingya Zhou Jian Cao Qiang Xu Xianlin Han Duan Wang Shengyu Zhang Dong Wu Department of Gastroenterology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China State Key Laboratory of Complex Severe and Rare Diseases Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Medical Records Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China WHO Family of International Classifications Collaborating Center of China Beijing 100730China Department of Radiology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China

Background:With the accumulation of experience and evidence,guidelines for invasive intervention for acute pancreatitis(AP)have continuously evolved,followed in Peking Union Medical College Hospital(PUMCH).We aimed to review AP case series to help understand the impact of guideline evolution on the management and prognosis of AP in real-world ***:This was a single-center study of AP patients who had received invasive interventions from 1988 to *** demographics,baseline severity,imaging findings,and the indication,timing,and specific modalities of invasive interventions were *** composite primary endpoint was death during hospitalization or major complications after *** endpoints included pancreatic fistula,incision infection,number of interventions,length of intensive care stay,length of hospitalization,and total medical ***:A total of 195 patients were *** most common indication for invasive intervention was suspected infection,followed by persistent *** step-up and delayed strategies reduced the incidence of major complications or *** 35 years,the number of patients requiring surgery has gradually declined,and more patients need only minimally invasive procedures for *** incidence of the primary outcome decreased as well as the duration of ***:The management of AP patients at PUMCH in the last 35 years has undergone therapeutic guideline changes that support the efficacy and safety of the deferred step-up strategy in real-world practice.

关键词： Acute pancreatitis Drainage invasive intervention Necrosectomy Step-up

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