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Regional homogeneity of intrinsic brain activity related to the main alexithymia dimensions

General Psychiatry 2018年第4期31卷 17-23页

作者： Han Dai Li Mei Mei Minjun Sun Xiaofei Institute of Psychological Sciences Hangzhou Normal UniversityHangzhouChina Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments HangzhouChina Center for Cognition and brain Disorders Hangzhou Normal UniversityHangzhouChina Mental Health Education and Counseling Center Hangzhou Normal UniversityHangzhouChina

Background Alexithymia is a multidimensional personality *** This study aims to investigate the neuronal correlates of each alexithymia dimension by examining the regional homogeneity （ReHo） of intrinsic brain activity in a resting *** From university freshmen, students with alexithymia and non-alexithymia were recruited. Their alexithymic traits were assessed using the Toronto Alexithymia Scale-20. The ReHo was examined using a resting-state functional MRI *** This study suggests signifcant group differences in ReHo in multiple brain regions distributed in the frontal lobe, parietal lobe, temporal lobe, occipital lobe and insular cortex. However, only the ReHo in the insula was positively associated with diffculty identifying feelings, a main dimension of alexithymia. The ReHo in the lingual gyrus, precentral gyrus and postcentral gyrus was？positively associated with diffculty describing feelings in？participants with？alexithymia. Lastly, the ReHo in the right dorsomedial prefrontal cortex （DMPFC_R） was negatively related to the externally oriented thinking style of participants with？*** In conclusion, these results suggest that the main dimensions of alexithymia are correlated with specifc brain regions’ function, and the role of the insula, lingual gyrus, precentral gyrus, postcentral gyrus and DMPFC_R in the neuropathology of alexithymia should be further investigated.

关键词： Regional homogeneity intrinsic brain activity the main alexithymia dimensions

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Concordance among indices of intrinsic brain function： Insights from inter-individual variation and temporal dynamics

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Science Bulletin 2017年第23期62卷 1572-1584页

作者： Chao-Gan Yan Zhen Yang Stanley J. Colcombe Xi-Nian Zuo Michael P. Milham CAS Key Laboratory of Behavioral Science Institute of Psychology Beijing 100101 China Departrnent of Psychology University of Chinese Academy of Sciences Beijing 100101 China Magnetic Resonance Imaging Research Center Institute of Psychology Chinese Academy of Sciences Beijing 100101 China center for Lifespan Innovation of Mind and brain Institute of Psychology Chinese Academy of Sciences Beijing China Nathan Kline Institute for Psychiatric Research Orangeburg NY 10962 USA Department of Child and Adolescent Psychiatry NYU Langone Medical Center School of Medicine New York NY 10016 USA Center for Neuromodulation in Depression and Stress Department of Psychiatry Perelman School of Medidne University of Pennsylvania Philadelphia PA 19104 USA Child Mind Institute New York NY 10022 USA

Various resting-state fMRI(R-fMRI) measures have been developed to characterize intrinsic brain activity. While each of these measures has gained a growing presence in the literature, questions remain regarding the common and unique aspects these indices capture. The present work provided a comprehensive examination of inter-individual variation and intra-individual temporal variation for commonly used measures, including fractional amplitude of low frequency fluctuations, regional homogeneity,voxel-mirrored homotopic connectivity, network centrality and global signal correlation. Regardless of whether examining intra-individual or inter-individual variation, we found that these definitionally distinct R-fMRI indices tend to exhibit a relatively high degree of covariation, which doesn't exist in phase randomized surrogate data. As a measure of intrinsic brain function, concordance for R-fMRI indices was negatively correlated with age across individuals(i.e., concordance among functional indices decreased with age). To understand the functional significance of concordance, we noted that higher concordance was generally associated with higher strengths of R-fMRI indices, regardless of whether looking through the lens of inter-individual(i.e., high vs. low concordance participants) or intra-individual(i.e., high *** concordance states identified via temporal dynamic analyses) differences. We also noted a linear increase in functional concordance together with the R-fMRI indices through the scan, which may suggest a decrease in arousal. The current study demonstrated an enriched picture regarding the relationship among the R-fMRI indices, as well as provided new insights in examining dynamic states within and between individuals.

关键词： Resting-state fMRI intrinsic brain activity Concordance Temporal dynamics Inter-individual variation

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