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Retrospective analysis of 56 patients with advanced gastric cancer treated with combination of intravenous and intra-arterial intensified neoadjuvant chemotherapy

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Chinese Medical Journal 2012年第5期125卷 780-785页

作者： LI Guo-li LIU Kun BAOYang CAO Jian-ming XU Jian WANG Xu-ling WU Bo LI Jie-shou Research Institute of General SurgeryJinling Hospital NanjingUniversity School of Medicine Nanjing Jiangsu 210-002 China Department of Medical ImagingJinli-ng-Hospital NanjingUniversity School of Medicine Nanjing Jiangsu 210-002 China Department of-Pathology Jinli-ng-Hospital NanjingUniversity School of Medicine Nanjing Jiangsu 210002 China

Background Pre-operative chemotherapy has gained widespread interest while treating advanced gastric cancer in eastern countries. However, there is currently no established standard regimen for gastric cancer. The aim of this research was to explore the value of preoperative chemotherapy with a combination of intravenous and intra-arterial intensified chemotherapy in advanced .qastric cancer.

关键词： advanced gastric cancer preoperative chemotherapy intra-arterial chemotherapy intravenous chemotherapy ways of drug administration

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More Cycles of intravenous chemotherapy are Associated with Reduced Growth in Children with Retinoblastoma

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Journal of Nutritional Oncology 2021年第3期6卷 126-133页

作者： Yu Qiong Yang Liang Yu Yin Xin Lin Bing Hao Xiao Yue Guan Hong Xia Xu Hong Feng Yuan Department of Ophthalmology Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China Department of Clinical Nutrition Daping HospitalArmy Medical University(Third Military Medical University)Chongqing 400042China Institute of Hepatopancreatobiliary Surgery Southwest HospitalArmy Medical University(Third Military Medical University)Chongqing 400038China

Background chemotherapy can have a negative impact on the growth of children with different cancers.However,few studies have examined whether intravenous chemotherapy(IVC)affects the growth of children with retinoblastoma(RB).The present study evaluated the height differences(actual height compared to the age standardized value)and survival of pediatric RB patients treated with IVC.Methods This was an observational cohort study.A total of 87 pediatric RB patients were included.The study population was stratified into two groups based on the number of chemotherapy cycles administered(≤4 versus>4).The height at baseline(before IVC),height after IVC and overall survival were compared between the two groups.Results Before IVC,no height differences were observed between the two groups(P=0.585).After IVC,all of the patients had a reduced height compared to the age standardized height(P=0.035).Patients who underwent more cycles of chemotherapy had a greater height difference compared to those who received fewer cycles(P=0.008).For those who had reduced height,the difference was positively associated with the number of chemotherapy cycles(r=0.279,P=0.043).Among the patients who exhibited a greater height difference,those who underwent more than four cycles of chemotherapy had a decreased overall survival(P=0.042).Conclusions Pediatric RB patients who underwent more cycles of chemotherapy were more likely to have a reduced height.Further studies are needed to determine the optimal treatment strategy to prevent the reduced growth while maintaining the benefits of chemotherapy.

关键词： Retinoblastoma intravenous chemotherapy Height Survival

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Efficacy of continuous gastric artery infusion chemotherapy in relieving digestive obstruction in advanced gastric cancer

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World Journal of Gastrointestinal Oncology 2023年第7期15卷 1283-1294页

作者： Rui Tang Guo-Feng Chen Kai Jin Guang-Qiang Zhang Jian-Jun Wu Shu-Gao Han Bin Li Ming Chao Department of Radiology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Gastrointestinal Surgery The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina

BACKGROUND Obstruction or fullness after feeding is common in gastric cancer(GC)patients,affecting their nutritional status and quality of life.Patients with digestive obstruction are generally in a more advanced stage.Existing methods,including palliative gastrectomy,gastrojejunostomy,endoluminal stent,jejunal nutrition tube and intravenous chemotherapy,have limitations in treating these symptoms.AIM To analyze the efficacy of continuous gastric artery infusion chemotherapy(cGAIC)in relieving digestive obstruction in patients with advanced GC.METHODS This study was a retrospective study.Twenty-nine patients with digestive obstruction of advanced GC who underwent at least one cycle of treatment were reviewed at The Second Affiliated Hospital of Zhejiang University School of Medicine.The oxaliplatin-based intra-arterial infusion regimen was applied in all patients.Mild systemic chemotherapy was used in combination with local treatment.The clinical response was evaluated by contrast-enhanced computed tomography using Response Evaluation Criteria In Solid Tumors(RECIST)criteria.Digestive tract symptoms and toxic effects were analyzed regularly.A comparison of the Karnofsky Performance Status(KPS)score and Stooler’s Dysphagia Score before and after therapy was made.Univariate survival analysis and multivariate survival analysis were also performed to explore the key factors affecting patient survival.RESULTS All patients finished cGAIC successfully without microcatheter displacement,as confirmed by arteriography.The median follow-up time was 24 mo(95%CI:20.24-27.76 mo).The overall response rate was 89.7%after cGAIC according to the RECIST criteria.The postoperative Stooler’s Dysphagia Score was significantly improved.Twentytwo(75.9%)of the 29 patients experienced relief of digestive obstruction after the first two cycles,and 13(44.8%)initially unresectable patients were then considered radically resectable.The median overall survival time(mOS)was 16 mo(95%CI:9.32-22.68 mo).Patients who received radical surgery had a

关键词： Intra-arterial infusion chemotherapy intravenous chemotherapy Interventional radiology Digestive obstruction Advanced gastric cancer Response evaluation criteria in solid tumors

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