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intratumoural microorganism can affect the progression of hepatocellular carcinoma

World Journal of Gastrointestinal Oncology 2024年第10期16卷 4232-4243页

作者： Bao-Qun Liu Yi Bai Da-Peng Chen Ya-Min Zhang Tian-Ze Wang Jing-Rui Chen Xiang-Yu Liu Bin Zheng Zi-Lin Cui First Central Clinical College Tianjin Medical UniversityTianjin 300070China Department of Hepatobiliary Surgery Tianjin First Central HospitalSchool of MedicineNankai UniversityTianjin 300192China Tianjin First Central Hospital Clinic Institute School of MedicineNankai UniversityTianjin 300192China School of Medicine Tianjin UniversityTianjin 300072China

BACKGROUND Several recent studies have confirmed that intratumoural microorganisms can affect the occurrence and development of hepatocellular carcinoma(HCC);however,their role in tumor progression remains ***,there is a need for further research on the role of intratumoural microorganisms in *** To investigate the changes in intratumoural microorganisms in HCC and the effect of Propionibacterium on HCC *** HCC and normal liver tissue specimens were subjected to fluorescence in situ hybridization(FISH).After performing 16S rRNA sequencing on HCC and peritumoral tissues to analyze the differences between the two *** was cocultured with HCC cells in *** in cell proliferation and migration capacity were *** expression of NF-κB pathway related proteins in tumor cells was *** orthotopic liver implantation model and the subcutaneous xenograft model were *** tissues and subcutaneous tumors were collected 2 weeks *** FISH demonstrated the presence of microorganisms in HCC and normal liver tissues.16S rRNA sequencing revealed an abundance of Lysobacter,Lachnospiraceae,Pseudomonas,and Lactobacillus in HCC *** distribution and abundance of Propionibacterium showed differences between HCC and peritumoral tissues(P<0.05).In vitro studies demonstrated that Propionibacterium and its metabolite propionic acid(PA)inhibited the proliferation and migration of HCC cells(P<0.05).The expression of the proteins in NF-κB signaling pathway also decreased in HCC cells(P<0.05).CONCLUSION Microorganisms in HCC and normal liver tissues displayed significant *** PA-producing bacterium Propionibacterium in HCC exerts an effect on the NF-κB pathway,thereby affecting the biological behavior of HCC.

关键词： Hepatocellular carcinoma intratumoural microbiome 16S rRNA sequencing Propionibacterium

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