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第三届国际仪器科学技术学术研讨会

作者： XIAO Chang-yan PAN Gang ZHANG Su HUANG Ting-lei CHEN Ya-zhu Institute of Biomedical Instrument ShangHai Jiao Tong University Shanghai 200030 China

This paper introduces a novel medical instrument for intraperitoneal hyperthermic perfusion in cancer treatment. The aim is to construct a PC-based virtual instrument system, which enables to automati

关键词： intraperitoneal hyperthermic perfusion virtual instrument temperature adjustment flux adjustment PID algorithm

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Chemotherapy with laparoscope-assisted continuous circulatory hyperthermic intraperitoneal perfusion for malignant ascites

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World Journal of Gastroenterology 2010年第15期16卷 1901-1907页

作者： Ba, Ming-Chen Cui, Shu-Zhong Lin, Sheng-Qu Tang, Yun-Qiang Wu, Yin-Bing Wang, Bin Zhang, Xiang-Liang Guangzhou Med Coll Canc Hosp Dept Abdominal Surg Sect 2 Guangzhou 510095 Guangdong Peoples R China

AIM:To investigate the procedure, feasibility and effects of laparoscopeassisted continuous circulatory hyperthermic intraperitoneal perfusion chemotherapy (CHIPC) in treatment of malignant ascites induced by peritoneal carcinomatosis from gastric cancers. METHODS: From August 2006 to March 2008, the laparoscopic approach was used to perform CHIPC on 16 patients with malignant ascites induced by gastric cancer or postoperative intraperitoneal seeding. Each patient underwent CHIPC three times after laparoscopeassisted perfusion catheters placing. The first session was completed in operative room under general anesthesia, 5% glucose solution was selected as perfusion liquid, and 1500 mg 5 fluorouracil (5FU) and 200 mg oxaliplatin were added in the perfusion solution. The second andthird sessions were performed in intensive care unit, 0.9% sodium chloride solution was selected as perfusion liquid, and 1500 mg 5FU was added in the perfusion solution alone. CHIPC was performed for 90 min at a velocity of 450600 mL/min and an in flow temperature of 43 ± 0.2℃.RESULTS: The intraoperative course was uneventful in all cases, and the mean operative period for laparoscopeassisted perfusion catheters placing was 80 min for each case. No postoperative deaths or complications related to laparoscopeassisted CHIPC occurred in this study. Clinically complete remission of ascites and related symptoms were achieved in 14 patients, and partial remission was achieved in 2 patients. During the followup, 13 patients died 29 mo after CHIPC, with a median survival time of 5 mo. Two patients with partial remission suffered from port site seeding and tumor metastasis,and died 2 and 3 mo after treatment. Three patients who are still alive today survived 4, 6 and 7 mo, respectively. The Karnofsky marks of patients (5090) increased significantly (P < 0.01) and the general status improved after CHIPC. Thus satisfactory clinical efficacy has been achieved in these patients treated by laparoscopic C

关键词： intraperitoneal hyperthermic perfusion Laparoscopy Chemotherapy Gastric cancer Malignant ascites

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