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Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet Chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.Lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity intradermal Vaccine

intradermal needle at auricular acupoint for insomnia:A randomized controlled trial

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World Journal of Acupuncture-Moxibustion 2020年第1期30卷 19-22页

作者： Jing CAO Min YAO De-guang DING Xiang XIANG Meng-tian XU College of Acupuncture and Orthopedics Hubei University of Chinese MedicineWuhan 430065China Department of Acupuncture and Moxibustion Hubei Provincial Hospital of Traditional Chinese MedicineWuhan 430061China

Objective:To compare whether there is clinical effects difference between intradermal needle at auricular acupoint and conventional acupuncture for ***:A total of 70 patients were randomly assigned into an intradermal needle group and an acupuncture group,35 patients in each *** 34 patients completed the study in the intradermal group,32 patients completed validly in the acupuncture *** patients in the intradermal needle group received intradermal needle therapy,in which the needle was imbedded subcutaneously at auricular acupoint:Shenmen(神门TF4),Pizhixia(皮质下AT4),Zhen(枕AT3),Xin(心CO15),and back-shu point:Ganshu(肝俞BL18),Xinshu(心俞BL15),Shenshu(肾俞BL23)and Pishu(脾俞BL20),as well as Anmian(安眠EX-HN18)retained for 2 days,and the patient would received a second therapy every other day,one course of treatment consisted of 3 times of *** patients in the acupuncture group received a conventional acupuncture therapy,in which Zhaohai(照海KI6),Shenmai(申脉BL62),Shenmen(神门HT7),Sanyinjiao(三阴交SP6),EX-HN18,Sishencong(四神聪EX-HN1)were punctured conventionally with needle and the needle was retained for 30 min,once per day,one course of treatment consisted of 5 times of *** and after the4 courses of treatment,Pittsburgh sleep quality index(PSQI)of the patients in the two groups were evaluated,and their clinical therapeutic effects were evaluated ***:There were no statistically significant differences of PSQI scores and clinical therapeutic effects of the patients with insomnia in two groups after treatment(both P>0.05).Conclusions:intradermal needle at auricular acupoint and conventional acupuncture therapy have comparable clinical therapeutic effects.

关键词： Acupuncture intradermal needle Insomnia Pittsburgh sleep quality index(PSQI) Randomized controlled trial(RCT)

Treatment of Patients with Vitiligo by intradermal Pricking of Vitiligenous Skin Using Sharp and Blunt Needle

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Journal of Cosmetics, Dermatological Sciences and Applications 2018年第4期8卷 256-263页

作者： Khalifa E. Sharquie Adil A. Noaimi Zahraa N. Al-Khafaji Department of Dermatology College of Medicine University of Baghdad Baghdad Iraq Iraqi and Arab Board for Dermatology & Venereology Baghdad Teaching Hospital Baghdad Iraq Department of Dermatology Baghdad Teaching Hospital Baghdad Iraq

Background: Vitiligo is a well known autoimmune disease, both cell mediated and humeral reaction are implicated in its etiopathogensis. Pricking of marginal pigmented of vitiligo skin to stimulate normal melanocytes to migrate into vitiligenous area and induce new melanogenesis and this is well known mechanism to induce repigmentation and supported by publications. Objective: To use needling technique by using blunt and sharp needle by doing pricking completely white vitiligo skin in order to stimulate residual melanocytes of basal layer and or the melanocytes of outer root sheath of hair follicles to proliferate and induce active melanogenesis. Patients and Methods: This is an interventional, therapeutic, comparative, study that was done in Department of Dermatology-Baghdad Teaching Hospital, Medical City, Baghdad, Iraq from April 2014-March 2015. Thirty five patient with vitiligo were enrolled in this study, their ages ranged from 5 - 55 (22.28 ± 12.09) years;15 patients treated with sharp needle, 2 males and 13 females and 20 patients treated with blunt needle, 4 males and 16 females. All clinical types of vitiligo including the generalized, localized and segmental were treated. The number of vitiligo patches varied between patients and the treated patches by sharp needle were 22 and by blunted needle were 20 patches. In both groups, needling was done geometrically, softly and rapidly in systemic horizontal rows away from pigmented margin and pigmented spot inside the patches and was not repeated. In Group A needle gauge 18 hold at 45° to skin surface and the distance between each pricking was 5 - 10 mm and similarly was done in Group B by using blunt needle. Each patient was advised to have daily sun light exposure for at least 15 min. Measuring the surface area of the lesions and calculating the reduction rate was done by using transparent with square paper and this was carried out every month till the end of the 4th month period of the treatment. All patients

关键词： Treatment Vitiligo intradermal Pricking Sharp and Blunt Needle

Factors affecting effectiveness of vaccination against hepatitis B virus in hemodialysis patients

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World Journal of Gastroenterology 2014年第34期20卷 12018-12025页

作者： Theodoros Eleftheriadis Georgios Pissas Georgia Antoniadi Vassilios Liakopoulos Ioannis Stefanidis Department of Nephrology Medical SchoolUniversity of Thessaly41110 LarissaGreece

Hepatitis B virus(HBV)is a major global health *** the success of the general measures against blood transmitted infections in hemodialysis(HD)units,the prevalence of HBV infection among the HD patients is still *** vaccination against HBV is indicating in this ***,compared with the general population the seroprotection achieved in HD patients remains relatively low,at about 70%.In this review patient,HD procedure and vaccine-associated factors that affect the efficacy of HBV vaccination are *** alternative routes of HBV vaccine administration as well as new and more immunogenic vaccine formulations are ***,besides scientific progress,vigilance of HD physicians and staff regarding the general measures against the transmission of blood borne infections and the vaccination against HBV is also required for reducing the prevalence of this viral infection.

关键词： Hemodialysis Hepatitis B virus epidemiology Hepatitis B virus vaccine Adjuvant Immunostimulant intradermal

Recent advances in vaccination of non-responders to standard dose hepatitis B virus vaccine

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World Journal of Hepatology 2015年第24期7卷 2503-2509页

作者： Saqib Walayat Zohair Ahmed Daniel Martin Srinivas Puli Michael Cashman Sonu Dhillon Department of Gastroenterology andHepatology University of Illinois PeoriaCampusOSF Saint Francis Medical Center Department of Internal Medicine Universityof Illinois Peoria CampusOSF Saint Francis Medical Center

Hepatitis B virus(HBV) infection is a global health problem. It is estimated there are more than 2 billion individuals exposed to the virus and 250 million are chronically infected. Hepatitis B is the cause of more than 600000 annual deaths due to cirrhosis and hepatocellular carcinoma. An effective vaccine exists and preventative initiatives center around universal vaccination especially in those at highest risk. Effective vaccination algorithms have led to a significant decline in the development of new infections and its devastating consequences. The vaccine is administered intramuscularly in three doses, with 95% showing long lasting serologic immunity. An additional fourth dose or a repeated higher dose three course regimen is given to those that fail to show immunity. Despite these additional regimens, some remain vulnerable to hepatitis B and are deemed nonresponders. Individuals with chronic disease states such as kidney disease, liver disease, diabetes mellitus, as well as those with a genetic predisposition, and those on immunomodulation therapy, have the highest likelihood of non-response. Various strategies have been developed to elicit an immune response in these individuals. These include increased vaccination dose, intradermal administration, alternative adjuvants, alternative routes of administration, co-administration with other vaccines, and other novel therapies. These alternative strategies can show improved response and lasting immunity. In summary, HBV vaccination is a major advance of modern medicine and all individuals at risk should be sought and vaccinated with subsequent adequate titers demonstrated.

关键词： Hepatitis B vaccine Non-responders intradermal vac

Brazilian vaccinia virus strains show a classical orthopoxvirus infection course and cross-protection

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Asian Pacific Journal of Tropical Medicine 2009年第2期2卷 21-26页

作者： Jaqueline Maria Siqueira Ferreira Betnia Paiva Drumond J?natas Santos Abraho Zélia Inês Portela Lobato Cláudio Ant?nio Bonjardim Paulo César Peregrino Ferreira Erna Geessien Kroon Laboratorio de Virus Departamento de MicrobiologiaInstituto de Ciencias Biologicas Departamento de Medicina Veterinaria Preventiva Escola de VeterindriaUniversidade Federal de Minas Gerais.Avenida Antonio Carlos6627caixa postal 486CEP 31270-901 Belo HorizonteMGBrazil

Objectives:The purpose of this work was to study the infection course and cross-protection in mice after intradermal injection of Vaccinia virus(VACV) strain Western Reserve and three Brazilian VACV strains: Aracatuba,Muriae and BeAn58058 isolated from cow,human and rodent,***:Balb/c mice were inoculated by footpad and back scarification and daily monitored regarding lesion development and weight *** check cross protection after intradermal VACV inoculation,mice were subsequendy infected with different VACV strains and monitored to check lesion *** neutralization assays were performed to check for the presence of antibodies against ***:After VACV intradermal inoculation the lesion development pattern was similar in mice infected with the different virus *** using the footpad scarification model,cross-protection among VACV strains was ***,neutralizing antibodies against Orthopoxvirus were detected in sera from mice infected with all VACV ***:Although it was not possible to observe virulence differences among VACV strains isolated from cow,rodent and human using the murine model,this inoculation route showed to be an appropriated model to study lesions development since it mimics natural infections by VACV in nature.

关键词： Orthopoxvirus Zoonoses Balb/c mice intradermal injection Vaccinia virus Bovine vaccinia outbreaks

Semi-Quantitative Histological Analysis of the Effect of Intense Pulsed Light (IPL) and Carbon Dioxide (CO<sub>2</sub>) Intradermic Injection on Fibroblast and Collagen Proliferation in the Skin of Wistar Rats

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第3期2卷 164-173页

作者： Tamara Lemos Maia-Figueiró Alexandre Nakao Odashiro Giovanna Padoa de Menezes Lilian Rezende Coelho Ili Breda Bruno Areco de Souza Ernesto Antonio Figueiró-Filho Faculty of Medicine Federal University of Mato Grosso do Sul Campo Grande Brazil Hospital Enfant-Jesus of University Laval Department of Pathology Quebec Canada Medical Residents University Hospital Federal University of Mato Grosso do Sul Campo Grande Brazil Post-Graduation Program Faculty of Medicine Federal University of Mato Grosso do Sul Campo Grande Brazil

Background: In recent years, so-called “non-ablative rejuvenation” has been carried out with the use of lasers or intense pulsed light (IPL) to stimulate collagen production by dermal fibroblasts. intradermal infusion of CO2 stimulates fibroblasts and the synthesis of collagen and elastin, contributing to the retraction of the skin and tissue rejuvenation. Objectives: To evaluate the effects of IPL and the intradermal infusion of CO2 on fibroblast proliferation and collagen in the skin of female rats. Methods: Sixteen adult female Wistar rats were divided into two groups of eight animals. Group 1 underwent IPL and group 2 underwent intradermal CO2 infusion. There was a total of 8 weeks of treatment. We conducted a punch in each animal before any procedure (T0), another punch in the middle of treatment at 4 weeks post-procedure (T1) and a punch at the end of treatment at 8 weeks post-procedure (T2). The cells involved in inflammation, fibrosis and vascularization of the injured tissue by histopathology were analyzed. Results: There was statistically significant fibroblast proliferation and collagen proliferation noted when analyzing all 16 animals together and also when considering the two study groups separately. In both groups, the greatest proliferation of fibroblasts coincided with periods of increased collagen production. Conclusion: Both IPL and intradermal CO2 infusion stimulated fibroblast and collagen proliferation in the skin of the rats studied.

关键词： Collagen Cosmetic Dermatology Rejuvenation Pulsed Light Intense Pulsed Light intradermal Injection

Success Story of a Low Cost Intra-Dermal Rabies Vaccination (IDRV) Clinic-Lessons Learnt over Five Years of 12,000 Patient Vaccinations “Without Failure” at DDU Hospital Shimla, Himachal Pradesh, India <br/>—“Saving a Drop of Rabies Vaccine and Immunoglobulins” 12 Innovations to Make Himachal Pradesh Rabies Free State by 2020

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World Journal of Vaccines 2015年第3期5卷 129-139页

作者： Omesh Kumar Bharti Shampur Narayan Madhusudana Ashok Kale Pyare Lal Gaunta Laxman Singh Chaudhry Jitender Kumar Nirmal Gupta Dropda Shyam Faculty Epidemiologist State Institute of Health & Family Welfare Parimahal Shimla India Professor of Neurovirology Head WHO Collaborating Centre for Reference and Research on Rabies Department of Neurovirology NIMHANS Bangalore India Professor Department of Community Medicine Dr. Ulhas Patil Medical College & Hospital Jalgaon India Rtd. Sr. Medical Superintendent DDU Hospital Shimla India Associate Professor Department of Pediatrics Indira Gandhi Medical College Shimla India Staff Nurse Anti-Rabies Clinic and Research Centre (ARC&RC) DDU Hospital Shimla India Multi Purpose Health Worker (MPW) previously at Anti-Rabies Clinic and Research Centre DDU Hospital Shimla India

Background: Rabies is a dreaded disease and an estimated 55,000 people die of rabies every year. Himachal Pradesh is in the North bordering China and is predominantly rural and hilly. Villages are near forests, where wild reservoirs of rabies exist. Since health facilities are not accessible easily, we need to innovate on existing schedules of rabies vaccination keeping in view the compliance of the patients and affordability so as to give them the best possible option of treatment. In the year 2006 and 2007, we, at DDU Hospital Shimla, experienced a severe shortage of rabies vaccine and patients were running from pillar to post to fetch rabies vaccine. At the same time, we learnt that some of the patients died because either they were not able to purchase the vaccine, mostly because of its high cost, $35, or they ignored the animal bites and did not seek the treatment. Since last year, we have been experiencing non-availability of rabies immunoglobulins (RIGs) in the market and have to innovate new schedules and techniques to save lives of the patients. Methods: During shortage of rabies vaccine in 2008, we contemplated to start a low cost intra-dermal (ID) clinic so as to make rabies vaccine affordable as intramuscular (IM) vaccination cost five times more than ID vaccination. But, there were three main hurdles. One hurdle was the non-availability of rabies vaccine vials having written on them “For IM/ID use” and another hurdle was only fewer animal bite patients attending the DDU Hospital, sometimes only one or two per day, which was insufficient to open a vaccine vial and distribute among them. The third problem being faced was reluctance of the hospital doctors to prescribe ID vaccine as this was not the practice at higher teaching institutions, including medical colleges. We contacted a vaccine company and few vials labeled as “For IM/ID use” were sourced from Mumbai (1200 km away from here). We asked the Chief Medical Officer, Shimla district to write a lette

关键词： intradermal Rabies Vaccination Local RIGs Infiltration Local Innovations Rabid Animals RIGs Scarcity One Health Zoonosis

Immunizing Vulnerable Populations Like Rag Pickers, Garbage Collectors, Municipality Workers and Newspaper Hawkers against Rabies in Shimla Municipality, HP, India

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World Journal of Vaccines 2015年第1期5卷 19-24页

作者： Omesh Kumar Bharti Corporation Health Officer Municipal Corporation Shimla India

Background: Rabies is a zoonotic disease and many vulnerable sections like rag pickers and municipality workers neglect animal bites due to ignorance of their potential deadly outcomes. Stray dogs abound in garbage pits and this population is exposed to their attacks. It should be a mandate for municipalities to help protect their sanitary workforce, especially rag pickers, from deadly infectious diseases such as Rabies, Hepatitis-B, HIV, Tetanus etc. Objectives: Objective of this study was to study methods to provide pre-exposure Rabies vaccination for such highly exposed populations by engaging them and understanding their perception of this disease through a constant dialogue with them. Methods: We started by engaging with the rag pickers to know how best to entice them to get themselves immunized. We then attempted to search literature for the most practical methods likely to succeed in reducing risk of rabies deaths in this population. Results: WHO approved 3 injections of 0.1 ml tissue culture vaccine on days 0, 7 and 21 were tried but were shown to result in many dropouts among rag pickers for repeat injections. We then followed a method where 0.1 ml of rabies vaccine was injected at 4 different anatomical sited in one setting. This proved acceptable and relatively inexpensive. A small number of subjects were studied by determination of neutralizing antibody by RFFIT, which proved immunogenic having anamnestic response on boosters given single IM or at 4 sites ID subsequently, implying that short schedule rabies pre-exposure vaccination can be done in high risk groups and may save lives if applied to the poorest that are highly exposed.

关键词： Pre-Exposure Rabies Vaccination intradermal Antirabies Vaccination (IDRV) Rag Pickers