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Quantitative analysis of intestinal gas in patients with acute pancreatitis

Hepatobiliary & Pancreatic Diseases International 2012年第3期11卷 314-318页

作者： Ying Liu and He-Sheng Luo Department of gastroenterology, Renmin Hospital, Wuhan University, Wuhan 430060, China Department of gastroenterology Renmin Hospital Wuhan University Wuhan 430060 China

BACKGROUND: Disturbance of gastrointestinal function is a common complication in the early phase of acute pancreatitis (AP). intestinal gas may reflect the function of the gut. Using plain abdominal radiographs, we investigated whether intestinal gas volume is related to AP. METHODS: Plain abdominal radiographs of 68 patients with AP within 24 hours after admission and 21 normal controls were digitized and transmitted to a computer. The region of intestinal gas was identified by an image manipulation software and the gas volume score (GVS) was calculated. The relationships between the GVS values and various clinical factors of AP were analyzed. RESULTS: The GVS in the AP group was 0.084±0.016, in the mild AP (MAP) group 0.070±0.005, and in the severe AP (SAP) group 0.094±0.013; all values were higher than that in the control group (Pintestinal gas volume is significantly elevated in patients with AP. It is closely related to Ranson’s and APACHE II score and secondary pancreatic and/or peripancreatic infection. GVS may be a new prognostic tool for assessing the severity of AP in the early course of the disease.

关键词： acute pancreatitis gas volume score intestinal gas gut motility bacterial overgrowth

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Functional findings in irritable bowel syndrome

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World Journal of gastroenterology 2006年第18期12卷 2830-2838页

作者： Iris Posserud Amanda Ersryd Magnus Simrén Department of Internal Medicine Sahlgrenska University HospitalGteborgSweden

The pathophysiology of IBS is complex and still incompletely known. Both central and peripheral factors, including psychosocial factors, abnormal GI motility and secretion, and visceral hypersensitivity, are thought to contribute to the symptoms of IBS. Several studies have demonstrated altered GI motor function in IBS patients and the pattern differs between IBS subgroups based on the predominant bowel pattern. Few studies have so far addressed GI secretion in IBS, but there are some evidence supporting altered secretion in the small intestine of IBS patients. Visceral hypersensitivity is currently considered to be perhaps the most important pathophysiological factor in IBS. Importantly, several external and internal factors can modulate visceral sensitivity, as well as GI motility, and enhanced responsiveness within the GI tract to for instance stress and nutrients has been demonstrated in IBS patients. Today IBS is viewed upon as a disorder of dysregulation of the so-called brain-gut axis, involving abnormal function in the enteric, autonomic and/or central nervous systems, with peripheral alterations probably dominating in some patients and disturbed central processing of signals from the periphery in others.

关键词： IBS gastrointestinal motility Visceral hypersensitivity gastrointestinal secretion intestinal gas Brain-gut axis Brain imaging Autonomic nervous system

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