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Chronic intestinal failure and short bowel syndrome in Crohn’s disease

World Journal of Gastroenterology 2021年第24期27卷 3440-3465页

作者： Aysegül Aksan Karima Farrag Irina Blumenstein Oliver Schröder Axel U Dignass Jürgen Stein Institute of Nutritional Sciences Justus-Liebig-UniversitätGiessen 35392Germany Department of Clinical Research Interdisziplinäres Crohn Colitis Centrum Rhein-MainFrankfurt am Main 60594Germany Department of Gastroenterology and Clinical Nutrition DGD Kliniken SachsenhausenTeaching Hospital of the JW Goethe UniversityFrankfurt am Main 60594Germany Department of Gastroenterology Hepatology and Clinical NutritionFirst Medical ClinicJW Goethe University HospitalFrankfurt am Main 60529Germany Department of MedicineⅠ Agaplesion Markus HospitalGoethe-UniversityFrankfurt am Main 60431Germany Institute of Pharmaceutical Chemistry JW Goethe University60438 Frankfurt am MainGermany

Chronic intestinal failure(CIF)is a rare but feared complication of Crohn’s *** on the remaining length of the small intestine,the affected intestinal segment,and the residual bowel function,CIF can result in a wide spectrum of symptoms,from single micronutrient malabsorption to complete intestinal *** of CIF has improved significantly in recent *** in home-based parenteral nutrition,in particular,have translated into increased survival and improved quality of ***,60%of patients are permanently reliant on parenteral *** results with new drugs such as teduglutide have added a new dimension to CIF *** outcomes of patients with CIF could be greatly improved by more effective prevention,understanding,and *** complex cases,the care of patients with CIF requires a multidisciplinary approach involving not only physicians but also dietitians and nurses to provide optimal intestinal rehabilitation,nutritional support,and an improved quality of ***,we summarize current literature on CIF and short bowel syndrome,encompassing epidemiology,pathophysiology,and advances in surgical and medical management,and elucidate advances in the understanding and therapy of CIF-related complications such as catheter-related bloodstream infections and intestinal failure-associated liver disease.

关键词： Chronic intestinal failure Short bowel syndrome Crohn's disease Inflammatory bowel disease Parenteral nutrition intestinal failure-associated liver disease

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