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Mechanism and potential treatments for gastrointestinal dysfunction in patients with COVID-19

World Journal of Gastroenterology 2022年第48期28卷 6811-6826页

作者： Yang Yao Zhu-Jun Liu Yu-Kun Zhang Hui-Jun Sun Chongqing Key Laboratory of Development and Utilization of Genuine Medicinal Materials in Three Gorges Reservoir Area College of Basic MedicalChongqing 404120China Department of Clinical Pharmacology College of PharmacyDalian 116044Liaoning ProvinceChina Ministry of Public Infrastructure Chongqing Three Gorges Medical CollegeChongqing 404120China Department of Basic Medicine Chongqing Three Gorges Medical CollegeChongqing 404120China Department of Business Administration Metropolitan College of Science and TechnologyChongqing 404120China State Key Laboratory of Natural and Biomimetic Drugs Department of PharmacologyPeking UniversityBeijing 100191China Department of Clinical Pharmacology College of PharmacyDalian Medical UniversityDalian 116044Liaoning ProvinceChina

The global coronavirus disease 2019(COVID-19)has become one of the biggest threats to the world since *** respiratory and gastrointestinal tracts are the main targets for severe acute respiratory syndrome coronavirus 2 infection for they highly express angiotensin-converting enzyme-2 and transmembrane protease serine *** patients suffering from COVID-19,gastrointestinal symptoms have ranged from 12%to 61%.Anorexia,nausea and/or vomiting,diarrhea,and abdominal pain are considered to be the main gastrointestinal symptoms of *** has been reported that the direct damage of intestinal mucosal epithelial cells,malnutrition,and intestinal flora disorders are involved in ***,the underlying mechanisms remain ***,in this study,we reviewed and discussed the correlated mechanisms that cause gastrointestinal symptoms in order to help to develop the treatment strategy and build an appropriate guideline for medical workers.

关键词： COVID-19 Angiotensin-converting enzyme-2 Transmembrane protease serine 2 Gastrointestinal symptom Mechanism intestinal barrier permeability

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intestinal barrier Function in the Pathogenesis of Nonalcoholic Fatty Liver Disease

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Journal of Clinical and Translational Hepatology 2023年第2期11卷 452-458页

作者： Lu Liu Minyue Yin Jingwen Gao Chenyan Yu Jiaxi Lin Airong Wu Jinzhou Zhu Chunfang Xu Xiaolin Liu Department of Gastroenterology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina

Nonalcoholic fatty liver disease(NAFLD)is the most common chronic liver disease *** mechanisms involved in NAFLD onset are complicated and *** literature has indicated that altered intestinal barrier function is related to the occurrence and progression of liver *** intestinal barrier is important for absorbing nutrients and electrolytes and for defending against toxins and antigens in the enteric *** mechanisms by which the intestinal barrier influences the development of NAFLD involve the altered epithelial layer,decreased intracellular junction integrity,and increased intestinal barrier *** intestinal permeability leads to luminal dysbiosis and allows the translocation of pathogenic bacteria and metabolites into the liver,inducing inflammation,immune response,and hepatocyte injury in *** research has been directed to NAFLD in recent decades,the pathophysiological changes in NAFLD initiation and progression are still not completely understood,and the therapeutic targets remain limited.A deeper understanding on the correlation between NAFLD pathogenesis and intestinal barrier regulation must be ***,in this review,the components of the intestinal barrier and their respective functions and disruptions during the progression of NAFLD are discussed.

关键词： Nonalcoholic fatty liver disease intestinal barrier intestinal barrier permeability Gut-liver axis

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