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Non-invasive assessment for intratumoural distribution of interstitial fluid flow

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Magnetic Resonance Letters 2023年第4期3卷 286-297页

作者： Jun Zhao Yupeng Cao Wentao Liu Dong Han CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing100190China School of Future Technology University of Chinese Academy of SciencesBeijing100049China

interstitial fluid plays a vital role in drug delivery and tumour ***,few non-invasive measurement methods are available for measuring low-velocity biological fluid ***,this study aimed to develop a novel technology called interstitial flow *** interstitial flow velocity-MRI sequence consists of a dual inversion recovery preparation and an improved stimulated echo sequence(ISTE)combined with phase-contrast MRI.A homemade flow phantom was used to assess the feasibility and sensitivity of interstitial flow *** addition,xenografts of female BALB/c mouse models of 4T1 breast cancer administered losartan(40 mg/kg)or saline(n?6)were subjected to imaging on a 7.0 T scanner to assess the in vivo interstitial fluid flow *** results showed a significant correlation(Pflow *** flow velocity-MRI could detect a velocity as low as 10.21±2.65 mm/s with a spatial resolution of 0.313 *** losartan group had a lower mean interstitial fluid velocity than the control group(85±16 vs 113±24 mm/s).In addition,compared to the saline treatment,losartan treatment reduced the proportion of collagen fibres by 10%and 12%in the Masson and Sirius red staining groups,*** flow velocity-MRI has the potential to determine interstitial fluid flow velocity non-invasively and exhibits an intuitive velocity map.

关键词： interstitial fluid flow interstitial flow velocity-MRI Losartan Slow flows Tumour microenvironment

Dynamics of Calcium Signal and Leukotriene C_(4) Release in Mast Cells Network Induced by Mechanical Stimuli and Modulated by interstitial fluid flow

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Advances in Applied Mathematics and Mechanics 2016年第1期8卷 67-81页

作者： Wei Yao Hongwei Yang Yabei Li Guanghong Ding Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function Department of Mechanics and Engineering ScienceFudan University220 Handan RoadShanghai 200433China

Mast cells(MCs)play an important role in the immune *** connective tissues,mechanical stimuli activate intracellular calcium signaling pathways,induce a variety of mediators including leukotriene C4(LTC4)release,and affect MCs’*** paper focuses on MCs’intracellular calcium dynamics and LTC4 release responding to mechanical stimuli,explores signaling pathways in MCs and the effect of interstitial fluid flow on the transport of biological messengers and feedback in the MCs *** use a mathematical model to show that(i)mechanical stimuli including shear stress induced by interstitial fluid flow can activate mechano-sensitive(MS)ion channels on MCs’membrane and allow Ca^(2+)entry,which increases intracellular Ca^(2+)concentration and leads to LTC4 release;(ii)LTC4 in the extracellular space(ECS)acts on surface cysteinyl leukotriene receptors(LTC4R)on adjacent cells,leading to Ca^(2+)influx through Ca^(2+)release-activated Ca^(2+)(CRAC)*** elevated intracellular Ca^(2+)concentration further stimulates LTC4 release and creates a positive feedback in the MCs *** findings of this study may facilitate our understanding of the mechanotransduction process in MCs induced by mechanical stimuli,contribute to understanding of interstitial flow-related mechanobiology in MCs network,and provide a methodology for quantitatively analyzing physical treatment methods including acupuncture and massage in traditional Chinese medicine(TCM).

关键词： Mast cells Ca^(2+)signaling LTC4 release interstitial fluid flow network

Fundamental kinematics laws of interstitial fluid flows on vascular walls

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Theoretical & Applied Mechanics Letters 2021年第3期11卷 146-150页

作者： Yajun Yin Hongyi Li Gang Peng Xiaobin Yu Yiya Kong Department of Engineering Mechanics Tsinghua UniversityBeijing 100084China Beijing Hospital National Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China

In the previous studies,the phenomenon that the interstitial fluid(ISF)can flow along tunica adventitia of the arteries and veins in both human and animal bodies was *** the basis of these studies,this paper aims to:(i)summarize the basic properties of the ISF flows in the walls of arteries and veins,(ii)combine the basic properties with axiomaticism and abstract the axiom for ISF flows,and(iii)propose three fundamental laws of the ISF flow,(i.e.,the existence law,the homotropic law and the reverse law).The three laws provide solid theoretical basement for exploring the kinematic patterns of interstitial fluid flow in the cardiovascular system.

关键词： Vascular walls interstitial fluid flow Essential flowing properties Fundamental kinematics laws

An analytical poroelastic model for laboratorial mechanical testing of the articular cartilage (AC)

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Applied Mathematics and Mechanics(English Edition) 2018年第6期39卷 813-828页

作者： Xiaogang WU Kuijun CHEN Zhaowei WANG Ningning WANG Teng ZHAO Yanan XUE Yanqin WANG Weiyi CHEN shanxi Key Laboratory of Material Strength & Structural Impact College of Mechanics Taiyuan University of Technology Taiyuan 030024 China

The articular cartilage （AC） can be seen as a biphasic poroelastic material. The cartilage deformation under compression mainly leads to an interstitial fluid flow in the porous solid phase. In this paper, an analytical poroelastic model for the AC under laboratorial mechanical testing is developed. The solutions of interstitial fluid pressure and velocity are obtained. The results show the following facts. （i） Both the pressure and fluid velocity amplitudes are proportional to the strain loading amplitude. （ii） Both the amplitudes of pore fluid pressure and velocity in the AC depend more on the loading amplitude than on the frequency. Thus, in order to obtain the considerable fluid stimulus for the AC cell responses, the most effective way is to increase the loading amplitude rather than the frequency. （iii） Both the interstitiM fluid pressure and velocity are strongly affected by permeability variations. This model can be used in experimental tests of the parameters of AC or other poroelastic materials, and in research of mechanotransduction and injury mechanism involved interstitial fluid flow.

关键词： articular cartilage (AC) poroelasticity interstitial fluid flow laboratorialmechanical test injury mechanism