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Current Urology 2024年第1期18卷 49-54页

作者： Ahmed S.El Hefnawy Mohamed Attya Ahmed Hasan Esam El Sawy Mohamed Abdel-Razik Nasr El-Tabey Mansoura Urology and Nephrology Center Faculty of MedicineMansoura UniversityMansouraEgypt

Objective:The aim of this study was to evaluate the feasibility of intravesical instillation of platelet-rich plasma(PRP)to treat interstitial cystitis/bladder pain syndrome(IC/BPS).Materials and methods:Twenty PRP samples were tested in vitro for stability after exposure to urine samples with different pH.A pilot study involving 21 female patients with IC/BPS was conducted,and 6 weekly doses of autologous PRP(50 mL)were *** were followed up at the 2nd,4th,8th,and 12th weeks after terminating *** primary endpoint was the visual analog scale(VAS)for pain,and the secondary endpoints included the IC symptom index,IC problem index of the O'Leary-Sant questionnaire and global response assessment,urine culture,and *** was defined as a reduction in VAS by 30%or more compared with basal level,and adverse events were ***:The mean±SD of VAS was significantly reduced compared with basal level(4.4±2.6 vs.8.8±1.1,respectively,p=0.001).Meanwhile,80%of cases were considered successful,with a 50.1%reduction in the mean score compared with the basal *** mean±SD of IC symptom index and IC problem index significantly improved compared with the basal *** response assessment was markedly,moderately,and slightly improved in 2(10%),10(50%),and 5(25%)patients,respectively,and showed no change in 3(15%).Three patients had positive urine cultures at follow-up,but 1 withdrew after 2 sessions because of a lack of ***:Repeated intravesical instillation of PRP could be considered an effective and safe approach for treating IC/BPS.

关键词： Bladder pain syndrome interstitial cystitis Platelet-rich plasma

Addressing quality of life in the patient with interstitial cystitis/bladder pain syndrome

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Asian Journal of Urology 2017年第1期4卷 50-54页

作者： Vinaya Vasudevan Robert Moldwin Department of Urology The Smith Institute for UrologyNorthwell HealthNew Hyde ParkNYUSA

interstitial cystitis/bladder pain syndrome(IC/BPS)is a debilitating,chronic condition characterized by chronic pelvic pain,urinary urgency,and frequency and is well-known to be associated with a decrease in work productivity,emotional changes,sleep,sexual dysfunction,and *** metrics of quality of life(QoL)in this patient population have been developed;however,a unified,standardized approach to QoL in these patients has not been *** effects of IC/BPS and co-morbid conditions on QoL are described using current validated ***,data regarding successful treatment of IC/BPS in terms of QoL improvement are *** QoL is the single most important clinical measure of success in the treatment of patients suffering from IC/BPS,addressing QoL in this patient population remains a significant challenge,as its effects on QoL are highly variable and unable to be differentiated from the effects of comorbid conditions on QoL,including depression,poor sleep,and inability to *** studies will need to address treatment efficacy on the basis of IC/BPS specific QoL metrics,and multi-modal assessment and therapy to address comorbid disease will also play an important role in the future to ensure comprehensive management of these patients.

关键词： interstitial cystitis Painful bladder syndrome Quality of life interstitial cystitis symptom index(ICSI) O’Leary-Sant questionnaire King’s health questionnaire Chronic pelvic pain

Risk factors for interstitial cystitis/painful bladder syndrome in patients with lower urinary tract symptoms： a Chinese multi-center study

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Chinese Medical Journal 2010年第20期123卷 2842-2846页

作者： LI Gui-zhong ZHANG Ning DU Peng YANG Yong WU Shi-liang XIAO Yun-xiang JIN Rui LIU Lei SHEN Hong DAI Yi Department of Urology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Department of Urology Peking University First HospitalBeijing 100034China Department of Urology Xiangya 2nd Hospital of Central South UniversityChangshaHunan 410011China Department of Urology West China Hospital Affiliated to Sichuan UniversityChengduSichuan 610041China

Background Despite 100 years of research, the continued absence of well-established risk factors impedes the diagnosis and treatment of interstitial cystitis/painful bladder syndrome （IC/PBS）. We aimed to identify risk factors in patients with lower urinary tract symptoms （LUTS） without urinary tract infection or benign prostate hyperplasia in *** A total of 397 outpatients with LUTS presenting for care to urology clinics in several hospitals throughout China were surveyed using a standardized questionnaire and validated outcome measures. The definitions for painful bladder syndrome based on the O‘Leary-Sant interstitial cystitis symptom and problem indices were used. The prevalence of possible risk factors was analyzed using the Fisher＇s exact test and Pearson chi-square test, and multivariate predictive models were developed using binary Logistic regression *** Of those multi-centre patients surveyed, including 174 women and 223 men, 41% （162/397） met criteria for painful bladder syndrome. There was a significant difference between women and men （55% （95/174） vs. 30% （67/223）,P 〈0.001）. Women with IC/PBS were more likely than those without IC/PBS to report a history of gynecological infections （odds ratio （OR）： 2.85; 95% confidence interval （CI）： 1.32-6.16, P=0.007）, intake of stimulatory foods （OR： 3.52; 95% CI：1.50-8.30; P=0.004）, irritable bowel （OR： 3.46; 95% CI： 1.22-9.80; P=0.014） and/or anorectal disease （OR： 2.68; 95% CI：1.12-6.40, P=0.023）. After adjusting for confounding factors, bladder pain was significantly associated with stimulatory foods （OR： 3.85; 95% CI： 1.58-9.36, P=0.003） and anorectal disease （OR： 2.76; 95% CI： 1.09-7.04, P=0.03） in *** beverage intake （OR： 3.54; 95% CI： 1.54-8.12, P=0.003） was identified the only modifiable association noted in multivariate analysis of *** We found that stimutatory foods, anorectal disease and caffeine beverages are potential risk factors for IC/PBS. Further studie

关键词： painful bladder syndrome interstitial cystitis questionnaire risk factor

Efficacy of transcutaneous tibial nerve stimulation in the treatment of bladder pain syndrome

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Current Urology 2022年第2期16卷 83-87页

作者： Okan Alkis Bekir Aras Mehmet Sevim İbrahim Güven Kartal Oğuzhan Yusuf Sönmez Halil İbrahim İvelik Department of Urology Kutahya Health Science UniversityKutahya43000Turkey

Background:This study aimed to demonstrate the effectiveness of transcutaneos tibial nerve stimulation(TTNS)in the treatment of bladder pain syndrome(BPS).Materials and methods:The data of 16 female patients,diagnosed with BPS in our clinic between 2019 and 2021 and had TTNS twice a week for 12 weeks,were retrospectively ***:The mean age of the patients was 46.00±13.11 years,and the mean body mass index was 26.43±3.07 kg/m^(2).After the treatment,the median day time frequency of the patients decreased from 13.37(3.69)to 10.25(4.56)(pinterstitial cystitis symptom index scores decreased from 17(4)to 15(10)(p=0.002).Conclusions:In this study it was demonstrated that TTNS is an alternative method that can be successfully applied before invasive methods in the treatment of BPS.

关键词： cystitis interstitial cystitis Transcutaneous electric nerve stimulation

Effects of Additional Glycine in Outpatients Being Treated for Urine Storage Disorders

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Open Journal of Urology 2021年第11期11卷 381-392页

作者： Kimio Sugaya Hitoshi Oh-Oka Tetsuo Yamada Masanobu Miyata Katsuhiro Ashitomi Katsumi Kadekawa Saori Nishijima Department of Urology Kitakami Central Hospital Okinawa Japan Southern Knights’ Laboratory Okinawa Japan Kobe Medical Center Kobe Japan Yamada Urological Clinic Sagamihara Japan Kitanodai Clinic Kitahiroshima Japan Department of Urology Okinawa Hokubu Hospital Okinawa Japan Department of Urology Okinawa Kyodo Hospital Okinawa Japan

Objectives: This study aimed to determine whether additional glycine can improve urine storage symptoms in outpatients. Methods: We recruited 50 outpatients (15 females, 35 males) with an Overactive Bladder Symptom Score (OABSS) of 3 or more. Participants being treated for urine storage disorders took additional glycine for 8 weeks at a dose of 3 g twice a day. Outcome measures included blood pressure, the International Prostate Symptom Score (IPSS), OABSS, Nocturia Quality of Life (N-QOL) score, urination frequency, sleep latency, time until the first void at night, bladder pain, improvement in urinary symptoms assessed with the Global Self-Assessment (GSA), and adverse events. Results: In the OABSS, the number of nighttime voids, urgency to urinate, urgent incontinence, and total score were improved. Improvements were also found in the IPSS total score for urine storage items, blood pressure, IPSS-QOL, time to first void, bladder pain, and GSA score, but no changes were seen in the frequency of urination at night, sleep latency or N-QOL score. No adverse events were recorded. Conclusion: Oral glycine improves objective and self-assessed urine storage symptoms, blood pressure, and bladder pain.

关键词： Chronic Prostatitis Glycine interstitial cystitis Overactive Bladder Urine Storage Symptoms