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Expression and functional study of cholecystokinin-A receptors on the interstitial cajal-like cells of the guinea pig common bile duct

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World Journal of Gastroenterology 2023年第38期29卷 5374-5382页

作者： Dan Xu Song-Lin Ma Man-Lin Huang Heng Zhang Department of Gastroenterology The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina Key Laboratory for Molecular Diagnosis of Hubei Province The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430014Hubei ProvinceChina

BACKGROUND Many studies have shown that interstitial cajal-like cell(ICLC)abnormalities are closely related to a variety of dynamic gastrointestinal *** are pacemaker cells for gastrointestinal movement and are involved in the transmission of nerve *** To elucidate the expression profile and significance of cholecystokinin-A(CCK-A)receptors in ICLCs in the common bile duct(CBD),as well as the role of CCK in regulating CBD motility through CCK-A receptors on CBD *** The levels of tyrosine kinase receptor(c-kit)and CCK-A receptors in CBD tissues and isolated CBD cells were quantified using the double immunofluorescence labeling *** CCK-mediated enhancement of the movement of CBD muscle strips through CBD ICLCs was observed by a muscle strip contraction *** Immunofluorescence showed co-expression of c-kit and CCK-A receptors in the CBD muscularis *** of isolated CBD cells showed that c-kit was expressed on the surface of ICLCs,the cell body and synapse were colored and polygonal,and some cells presented protrusions and formed networks adjacent to the CBD while others formed filaments at the synaptic terminals of local ***-A receptors were also expressed on CBD *** concentrations ranging from 10^(-6) mol/L to 10^(-10) mol/L,CCK promoted CBD smooth muscle contractility in a dose-dependent *** contrast,after ICLC removal,the contractility mediated by CCK in CBD smooth muscle *** CCK-A receptors are highly expressed on CBD ICLCs,and CCK may regulate CBD motility through the CCK-A receptors on ICLCs.

关键词： interstitial cajal-like cells Tyrosine kinase receptor Common bile duct Cholecystokinin-A receptors

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interstitial cajal-like cells arrhythmogenic potential substrate of pulmonary veins

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South China Journal of Cardiology 2010年第2期11卷 129-136页

作者：卢少平 Department of Cardiology Tangdu Hospital Affiliated to Fourth Military Medical University

interstitial cajal-like cells(ICLC) have been found in the atrium,ventricle and pulmonary vein in human and *** with very long processes and space structure,Cell processes establish close spatial relationships between each other, as well as with cardiomyocyte and nerve *** appear located among the myocardial cells and particularly at the border between the myocardial sleeve and pulmonary vein *** seems to possess automaticity and triggered *** is a potential substrate for arrhythmia.

关键词： interstitial cajal-like cells arrhythmia

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Cholesterol gallstones:Focusing on the role of interstitial cajal-like cells

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World Journal of Clinical Cases 2021年第15期9卷 3498-3505页

作者： Bei-Bei Fu Jian-Nan Zhao Shuo-Dong Wu Ying Fan Department of Health Management Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of General Surgery Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

with a complex and multifactorial *** gallbladder motility reportedly contributes to CG ***,interstitial cajal-like cells(ICLCs)are reportedly present in human and guinea pig gallbladder *** potentially contribute to the regulation of gallbladder motility,and aberrant conditions involving the loss of ICLCs and/or a reduction in its pacing potential and reactivity to cholecystokinin may promote CG *** review discusses the association between ICLCs and CG pathogenesis and provides a basis for further studies on the functions of ICLCs and the etiologies of CG.

关键词： interstitial cajal-like cells Cholesterol gallstones Gallbladder motility Biliary system disease Gallstones

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Effect of cholesterol on in vitro cultured interstitial cajal-like cells isolated from guinea pig gallbladders

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World Journal of Gastrointestinal Surgery 2020年第5期12卷 226-235页

作者： Bei-Bei Fu Jin-Huang Xu Shuo-Dong Wu Ying Fan Department of Health Management Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of General Surgery Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina

BACKGROUND Loss and/or dysfunction of interstitial cajal-like cells(ICLCs)in the gallbladder may promote cholesterol gallstone formation by decreasing gallbladder *** To study the effect of cholesterol on the proliferation and apoptosis of ICLCs from guinea pig *** Guinea pig gallbladder ICLCs were isolated and cultured in *** cells were exposed to cholesterol solutions at different concentrations(0,25,50,and 100 mg/L)for 24 ***,cell proliferation was detected by the CCK-8 method and the apoptosis rate was detected by flow ***,the expression of the c-Kit protein was detected by Western blot and the expression level of c-Kit m RNA in the cells was detected by real-time quantitative *** After ICLCs were cultured with cholesterol at concentrations of 25,50,and 100 mg/L,the proliferation rates decreased significantly(P<0.05),whereas the apoptosis rates increased significantly(P<0.05).Moreover,the expression of cKit protein and m RNA decreased significantly(P<0.05).CONCLUSION High cholesterol concentrations can inhibit the proliferation of ICLCs and promote *** decrease in the ICLC proliferation rate might be caused by the inhibition of the stem cell factor/c-Kit signaling pathway.

关键词： interstitial cajal-like cells Cholesterol Apoptosis c-Kit

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