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interstitial lung disease and diabetes

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World Journal of Diabetes 2020年第8期11卷 351-357页

作者： Venkat Rajasurya Kulothungan Gunasekaran Salim Surani Department of Pulmonary and Critical Care Novant Health SystemWinston-SalemNC 27103United States Department of Pulmonary and Critical Care Yale-New Haven Health Bridgeport HospitalCT 06610United States Department of Pulmonary Critical Care and Sleep Medicine Texas A&M Health Science CenterBryanTX 77807United States

Diabetes mellitus (DM) is a chronic metabolic disease and its prevalence has beensteadily increasing all over the world. DM and its associated micro andmacrovascular complications result in significant morbidity and mortality. Themicrovascular complications are usually manifested as retinopathy, neuropathy,nephropathy and macrovascular complications generally affect the cardiovascularsystem. In addition to these complications, DM also affects the lungs because of itsrich vascularity and abundance in connective tissue (collagen and elastin). DMhas been found to cause microvascular complications and proliferation ofextracellular connective tissue in the lungs, leading to decline in lung function in arestrictive pattern. interstitial lung disease (ILD) includes a diverse group ofdisease conditions characterized by different degrees of inflammation and fibrosisin the pulmonary parenchyma. Idiopathic pulmonary fibrosis (IPF) is one of thecommon type of idiopathic interstitial pneumonia with a high mortality rate. IPFis characterized by chronic progressive fibrosis leading to progressive respiratoryfailure. In this review we focus on lung as the target organ in DM and theassociation of DM and ILD with special emphasis on IPF.

关键词： Diabetes mellitus interstitial lung disease Idiopathic pulmonary fibrosis Metformin Diabetes complications Pulmonary function test Restrictive lung disease Hyperglycemia

Vedolizumab-associated diffuse interstitial lung disease in patients with ulcerative colitis:A case report

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World Journal of Clinical Cases 2022年第5期10卷 1716-1722页

作者： Jie Zhang Mei-Hong Liu Xue Gao Chang Dong Yan-Xia Li Department of Pulmonary and Critical Care Medicine First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina Department of Pathology First Affiliated Hospital of Dalian Medical UniversityDalian 116011Liaoning ProvinceChina

BACKGROUND Vedolizumab,a newer class of integrin antagonist biological agents,has been applied to treat patients with moderate-to-severe Crohn’s disease(CD)and ulcerative colitis(UC),especially for patients who are refractory to traditional therapies and tumor necrosis factor ***,some rare but lifethreatening adverse effects warrant *** describe the first fatal case of vedolizumab-associated severe diffuse interstitial lung disease in *** SUMMARY We present a case of new-onset diffuse parenchymal lung disease developing under treatment with vedolizumab in a patient with *** two doses of vedolizumab,he developed persistent fever and progressively worsening *** workups,including bronchoalveolar lavage,transbronchial lung biopsy and metagenomic next-generation sequencing,identified no infectious causes,and other potential causes(such as tumors and cardiogenic pulmonary edema)were also *** a result,a diagnosis of vedolizumabrelated interstitial lung disease was ***,although corticosteroids and empiric antibiotics were administered,the patient eventually died of respiratory *** Vedolizumab-related interstitial lung disease in patients with UC is rare but potentially *** and pulmonologists should be aware of vedolizumab-related adverse drug reactions.

关键词： Vedolizumab Adverse effects Ulcerative colitis Inflammatory bowel disease interstitial lung disease Case report

Association between the lung Immune Prognostic Index and mortality in patients with idiopathic inflammatory myopathy-associated interstitial lung disease

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Asian Pacific Journal of Tropical Medicine 2023年第11期16卷 515-521页

作者： Dan Luo Zhihao Zhao Caizheng Li Wenjun Zhu Wei Zhou Lirong He Huifeng Yan Qiaoli Su General Practice Ward/International Medical Center Ward General Practice Medical CenterWest China HospitalSichuan UniversityChengdu 610041China Department of Biomedical Engineering the Chinese University of Hong KongSha TinHong Kong SAR 999077China Department of Respiratory Medicine the Second Affiliated Hospital of Nanchang UniversityNo.1 Minde RoadNanchang 330006China Center for Prevention and Treatment of Cardiovascular diseases the Second Affiliated Hospital of Nanchang UniversityNanchang 330006China Department of Medical Imaging Center the Second Affiliated Hospital of Nanchang UniversityNo.1 Minde RoadNanchang 330006China

Objective:To explore the association between the lung Immune Prognostic Index(LIPI)and 1-year all-cause mortality in patients with idiopathic inflammatory myopathy related interstitial lung disease(IIM-ILD).Methods:Patients who were diagnosed with IIM-ILD at West China Hospital,Sichuan University from January 2008 to December 2021 were retrospectively included and categorized into three groups based on *** and multivariable Cox proportional hazards models were conducted to explore potential association between the LIPI and patients'***:A total of 1116 patients were screened,and 830 were included in this *** multivariable Cox analysis showed that,compared with patients with poor LIPI,the hazard ratio(HR)for all-cause 1-year mortality was 0.22(95%CI 0.05-0.93,P=0.04)for patients in the good LIPI group(LDH<250 IU/L and dNLR<3).After excluding patients lost to follow-up within one year,a similar result was found for LIPI(HR 0.20,95%CI 0.05-0.86;P=0.03).Conclusions:Good LIPI was independently associated with decreased risk of all-cause 1-year mortality in patients with *** easy-to-obtain index might be served as a potential marker for assessing the prognosis of IIM-ILD.

关键词： Idiopathic inflammatory myopathy interstitial lung disease lung Immune Prognostic index All-cause mortality

Clinical evolution of antisynthetase syndrome-associated interstitial lung disease after COVID-19 in a man with Klinefelter syndrome:A case report

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World Journal of Clinical Cases 2024年第6期12卷 1144-1149页

作者： Xiang-Xiang Wu Jian Cui Shi-Yao Wang Tian-Tian Zhao Ya-Fei Yuan Long Yang Wei Zuo Wen-Jian Liao Department of Respiratory and Critical Care The First Affiliated HospitalJiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina China-Japan Friendship Jiangxi Hospital Nanchang 330006Jiangxi ProvinceChina Department of Pulmonary and Critical Care Medicine Center of Respiratory MedicineChina-Japan Friendship HospitalBeijing 100029China

BACKGROUND This study presents a case of rapidly developing respiratory failure due to antisynthetase syndrome(AS)following coronavirus disease 2019(COVID-19)in a 33-year-old man diagnosed with Klinefelter syndrome(KS).CASE SUMMARY A 33-year-old man with a diagnosis of KS was admitted to the Department of Pulmonary and Critical Care Medicine of a tertiary hospital in China for fever and shortness of breath 2 wk after the onset of *** tomography of both lungs revealed diffuse multiple patchy heightened shadows in both lungs,accompanied by signs of partial bronchial *** next-generation sequencing of the bronchoalveolar lavage fluid suggested absence of pathogen.A biopsy specimen revealed organizing pneumonia with alveolar septal ***,extensive auto-antibody tests showed strong positivity for anti-SSA,anti-SSB,anti-Jo-1,and *** multidisciplinary discussions,the patient received a final diagnosis of AS,leading to rapidly progressing respiratory *** This study underscores the clinical progression of AS-associated interstitial lung disease subsequent to viral infections such as COVID-19 in patients diagnosed with KS.

关键词： Antisynthetase syndrome COVID-19 Klinefelter syndrome interstitial lung disease Anti-Jo-1 Case report

EFFECTS OF ALVEOLAR MACROPHAGE CONDITIONED MEDIA FROM interstitial lung disease PATIENTS ON THE PROCOLLAGEN mRNA EXPRESSION IN HUMAN lung FIBROBLASTS

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Chinese Medical Sciences Journal 1996年第1期11卷 25-27页

作者：郭子健朱元珏刘秉慈朱亚玲赵文理陈勇 Department of Internal Medicine PUMC Hospital Beijing.

Progressive inflammation and fibrosis are the central processes in the pathogenesis of pulmonary fibrosis. It is believed that macrophages in areas of chronically inflamed lung play a key role in fibrotic response. Therefore, we investigated the effects of alveolar macrophage (AmΦ) conditioned media from interstitial lung disease (ILD) patients on lung fibroblast proliferation and procollagen mRNA expression. After stimulating with AmΦ conditioned media from ILD patients, the fibroblast proliferation increased 71. 4 % compared with the control, but for media from bronchial carcinoma (BC) patients, it just increased 14. 3%. There is a significant difference between the two groups (P<0. 05). The procollagen a1 (Ⅰ) mRNA in fibroblasts stimulated with AmΦ conditioned media from ILD patients was increased 21. 3 %, and a1 ( Ⅲ) was 37. 2% higher than control (P<0.05). It increased 6. 8% and 12. 8% for media from BC patients respectively, but there was no difference when compared to the control. We considered that AmΦ from ILD patients might be in an activated state and could release some growth factors to stimulate fibroblast proliferation and promote collagen DNA expression.

关键词： interstitial lung disease alveolar macrophage procollagen

α2,3-Sialylation with Fucosylation Associated with More Severe Anti-MDA5 Positive Dermatomyositis Induced by Rapidly Progressive interstitial lung disease

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Phenomics 2023年第5期3卷 457-468页

作者： Rongrong Zhang Li Guo Jichen Sha Shuwai Chang Jiangfeng Zhao Kaiwen Wang Jiucun Wang Jianxin Gu Jing Liu Shifang Ren NHC Key Laboratory of Glycoconjugates Research Department of Biochemistry and Molecular BiologySchool of Basic Medical SciencesFudan UniversityShanghai 200032China Zhangjiang Fudan International Innovation Center Human Phenome InstituteFudan UniversityShanghai 200032China Department of Rheumatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200032China State Key Laboratory of Genetic Engineering School of Life ScienceFudan UniversityShanghai 200032China

Dermatomyositis(DM)is a heterogeneous autoimmune disease associated with numerous myositis specific antibodies(MSAs)in which DM with anti-melanoma differentiation-associated gene 5-positive(MDA5+DM)is a unique subtype of DM with higher risk of developing varying degrees of interstitial lung disease(ILD).Glycosylation is a complex posttranslational modification of proteins associated with many autoimmune ***,the association of total plasma N-glycome(TPNG)and DM,especially MDA5+DM,is still *** of 94 DM patients and 168 controls were analyzed by mass spectrometry with in-house reliable quantitative method called Bionic Glycome *** regression with age and sex adjusted was used to reveal the aberrant glycosylation of DM and the association of TPNG and MDA5+DM with or without rapidly progressive ILD(RPILD).The elastic net model was used to evaluate performance of glycans in distinguishing RPLID from non-RPILD,and survival analysis was analyzed with N-glycoslyation score by Kaplan-Meier survival *** was found that the plasma protein N-glycome in DM showed higher fucosylation and bisection,lower sialylation(α2,3-notα2,6-linked)and galactosylation than *** MDA5+DM,more severe disease condition was associated with decreased sialylation(specificallyα2,3-sialylation with fucosylation)while accompanying elevated H6N5S3 and H5N4FSx,decreased galactosylation and increased fucosylation and the complexity of ***,glycosylation traits have better discrimination ability to distinguish RPILD from non-RPILD with AUC 0.922 than clinical features and is *** advantage accrued to MDA5+DM with lower N-glycosylation score(p=3e-04).Our study reveals the aberrant glycosylation of DM for the first time and indicated that glycosylation is associated with disease severity caused by ILD in MDA5+DM,which might be considered as the potential biomarker for early diagnosis of RPILD and survival evaluation of MDA5+DM.

关键词： Dermatomyositis Anti-melanoma differentiation-associated gene 5-positive interstitial lung disease Glycosylation Matrix assisted laser desorption/ionization time of flight mass spectrometry

Characteristics and Prognosis of Microscopic Polyangiitis Patients with Diffuse Alveolar Hemorrhage and interstitial lung disease

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Chinese Medical Sciences Journal 2022年第4期37卷 293-302页

作者： Yu Gu Ting Zhang Min Peng Juhong Shi Department of Respiratory and Critical Care Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100037China

Objective To evaluate the clinical characteristics and prognostic predictors of patients with diffuse alveolar hemorrhage(DAH)and/or interstitial lung disease(ILD)secondary to microscopic polyangiitis(MPA)in a Chinese general *** We retrospectively reviewed the medical records of MPA patients admitted to internal medicine departments between the year 2002 and *** patients were divided into the ILD,DAH,DAH combined with ILD(DAHILD),and no pulmonary involvement(NPI)groups according to pulmonary involvement *** clinical characteristics at diagnosis were *** risk factors associated with short-term death and long-term death were identified with Logistic regression and Cox *** Of 193 newly diagnosed MPA patients,181 patients were enrolled in the research,of which 19 had DAH alone,96 had ILD alone,18 had DAH and DAH concurrently,and 48 had *** median of serum creatine level in the DAH group was 449μmol/L,significantly higher than that in the ILD group(123μmol/L,Nemenyi=-35.215,P=0.045)and DAHILD group(359μmol/L,Nemenyi=-43.609,P=0.007).The median follow-up time was 67(range:1-199)*** in the ILD group were older than those in the DAH group(median:69 years vs.57 years,Nemenyi=43.853,P=0.005).The patients with both DAH and ILD had combined features of the two subtypes,and the highest mortality(72.2%at the end of follow-up).The elevated white blood cell count was a risk factor for short-term death(OR=1.103,95%CI:1.008-1.207,P=0.032 for one month;OR=1.103,95%CI:1.026-1.186,P=0.008 for one year).Old age(HR=1.044,95%CI:1.023-1.066,P<0.001),cardiovascular system involvement(HR=2.093,95%CI:1.195-3.665,P=0.010),poor renal function(HR=1.001,95%CI:1.000-1.002,P=0.032)were risk factors for long-term *** infections(38/54)were the leading causes of death,especially for the patients with ***,49 patients suffered from pulmonary infections in the first year after *** MPA patients who prese

关键词： microscopic polyangiitis diffuse alveolar hemorrhage interstitial lung disease mortality risk factors

Acute exacerbation of interstitial lung disease in the intensive care unit:Principles of diagnostic evaluation and management

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World Journal of Critical Care Medicine 2023年第3期12卷 153-164页

作者： Muhammad K Hayat Syed Or Bruck Anupam Kumar Salim Surani Pulmonary and Critical Care Medicine Baylor College of MedicineHoustonTX 77030United States Department of Medicine and Pharmacology Texas A&M UniversityCollege StationTX 77843United States

interstitial lung disease(ILD)is typically managed on an outpatient *** care physicians manage patients with ILD in the setting of an acute exacerbation(ILD flare)causing severe *** principles of management of acute exacerbation of ILD are different from those used to manage patients with acute respiratory distress syndrome from sepsis,*** patients may be candidates for aggressive measures like extracorporeal membrane oxygenation and lung transplantation,while almost all patients will benefit from early palliative *** review focused on the types of ILD,diagnosis,and management pathways for this challenging condition.

关键词： interstitial lung disease Pulmonary fibrosis Acute exacerbation of interstitial lung disease Extracorporeal membrane oxygenation interstitial lung disease flare Immunosuppression

Mechanism prediction of Astragalus mongholicus Bunge and Angelica sinensis Diels in treating interstitial lung disease based on network pharmacology and molecular docking

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TMR Pharmacology Research 2023年第4期3卷 1-9页

作者： Jun Du Jian Hao Wei Wei Department of Rheumatology and Immunology Tianjin Medical University General HospitalTianjin 300052China

Objective:To investigate the mechanism by which Astragalus mongholicus Bunge(AM),and Angelica sinensis Diels(AS)act in interstitial lung disease(ILD)based on computational ***:We screened the ingredients of AM and AS in PubMed,the Web of Science,China National Knowledge Infrastructure(CNKI)Databases,*** obtained the potential effective *** sharing the same molecular with ILD,we got the possible target genes for ILD treatment and constructed components–targets–disease network with Cytoscape *** CTD(Comparative Toxicogenomics Database)database was used for GO and KEGG enrichment analysis of these target ***:59 active ingredients that can be druggable were chosen from AM,67 active ingredients were chosen from AS.77 overlapping target genes for AM and ILD and 36 overlapping target genes for AS and ILD were *** hub targets of AM were PTGS2,PTGS1,CDK2,MAOA,ESR1,TOP2A,GSK3B,ESR2,PPARG,NOS2,The hub targets of AS were PTGS2,GABRA1,PTGS1,CHRM1,SLC6A2,ADRA1B,ADRAIA,ADRB2,CHRM3,GABRA2,***,kaempferol,daidzein,pavilion,7-Hydroxycoumarin,and 5-Hydroxycoumarin were the main active ingredients which have more effective *** of the protein-protein interaction network showed PTGS2,GSK3B,PPARG,etc.,were the important predicted *** enriched KEGG pathways,including the Immune System,Metabolism of lipids and lipoproteins,Cytokine Signaling in the Immune system,Generic Transcription Pathway,The interleukin pathway,Metabolism of proteins,PI3K-Akt signaling pathway,Metabolic pathways,Innate Immune System,Neuroactive ligand-receptor interaction,Metabolism,GPCR downstream signaling,Amine ligand-binding receptors,Class A/1,Calcium signaling *** docking showed that quercetin,kaempferol,daidzein,pavilion,7-Hydroxycoumarin,5-Hydroxycoumarin had good binding activities with PTGS2 and GSK3B,which mainly mediated PI3K/Akt and other important signaling pathways in the pathogenesis of ***

关键词： Astragalus mongholicus Bunge Angelica sinensis Diels computational prediction interstitial lung disease PI3K-Akt signaling pathways