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Clinicopathological Study of Sporadic Burkitt Lymphoma in Children

Chinese Medical Journal 2015年第4期128卷 510-514页

作者： Hui Huang Zhi-Liang Liu Hua Zeng Shou-Hua Zhang Chuan-Sheng Huang Hong-Yan Xu Yan Wu Song-Tan Zeng Feng Xiong Wen-Ping Yang Department of Pathology Jiangxi Children's Hospital Nanchang Jiangxi 330006 China Department of Pathology Jiangxi Province Tumor Hospital Nanchang Jiangxi 330029 China Department of General Surgery Jiangxi Children@s Hospital Nanchang Jiangxi 330006 China

Background：Non-Hodgkin lymphoma is the fourth most common malignant tumors in children,Burkitt lymphoma （BL） accounts for 30-50％ of all pediatric *** aim of this study was to investigate the clinicopathologic features,immunophenotype,Epstein-Barr virus （EBV） infection and c-myc gene rearrangement of sporadic BL in ***：Ninety-two cases of pediatric BL were retrospectively analyzed for clinical features,immunohistochemistry,EBV-encoded RNA （EBER） status by in situ hybridization and c-myc gene rearrangement by fluorescence in situ ***：In the 92 cases,male is predominant in sex distribution （M：F =3.38：1）.The average age at diagnosis was 4.97 *** BL showed a lower clinical stage （P =0.002）,and advanced clinical stage and low serum albumin level at diagnosis were associated with poor outcome （P =0.024 and 0.053,respectively）.The positive expression of CD10,B-cell lymphoma-6,MUM1 and EBER were 95.7％（88 cases）,92.4％（85 cases）,22.8％（21 cases）,41.3％（38 cases）,*** expression of MUM1 were not associated with EBV infection status （P =1.000）.c-myc gene rearrangement was detected in 94.6％（87/92）.Clinical treatment information for 54 cases was collected,21 patients died of tumor after surgery alone,33 patients received surgery and chemotherapy,and of which six patients died shortly afterwords （MUM 1 positive expression in 3 cases,P =0.076）.Conclusions：The anatomical location,growth pattern and serum albumin level of BL were associated with biological ***1 may be a potential adverse prognostic marker,and not associated with EBV infection status.

关键词： Burkitt Lymphoma Epstein-Barr Virus interphase fluorescence in situ hybridization MUM1 Protein

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APPLICATION OF TWO-COLOR interphase FISH USING SEX PROBE IN ALLOGENEIC STEM CELL TRANSPLANTATION

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Chinese Journal of Cancer Research 2002年第1期14卷 73-75页

作者：曾慧兰李建勇朱康儿薛永权李杨秋刘晓力过宇 First Affiliated Hospital Medical College Jinan University Guangzhou 510630 First Affiliated Hospital Nanjing University Nanjing 210008 Institution of Hematology of Jiangsu Province Suzhou 215007 Nanfang Hospital First Military Medical University Guangzhou 510515

Objective: To evaluate the significance of two-color interphase fluorescence in situ hybridization (FISH) using X and Y centromere probe in the engraftment estimation and minimal residual disease (MRD) monitoring after allogeneic stem cell transplantation (alloSCT). Methods: Samples from 12 cases patients in different periods after alloSCT were detected by interphase FISH. Results: All of the 12 patients were proved to obtain engraftment 22–35 days after alloSCT. While traditional karyotype showed as 100%XX or 100%XY invariably, FISH showed different percentages of donor original sex chromosome. Conclusion: Two-color interphase FISH is a more sensitive and simple test for engraftment evaluation and MRD monitoring post SCT, though, it can not entirely replace traditional karyotype analysis and gene detection by RT-PCR.

关键词： Allogeneic stem cell transplantation interphase fluorescence in situ hybridization Engraftment Minimal residual disease

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