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Evolution and current status of the subclassification of intermediate hepatocellular carcinoma

World Journal of Gastrointestinal Surgery 2020年第3期12卷 85-92页

作者： Peng-Sheng Yi Hong Wang Jian-Shui Li Department of Hepato-biliary-pancrease Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Orthopedics Affiliated Hospital of Guizhou Medical UniversityGuiyang 550001Guizhou ProvinceChina

The staging and treatment of intermediate hepatocellular carcinoma(HCC)remains *** to the recommendations of Barcelona Clinic Liver Cancer staging system,patients with intermediate HCC are candidates for transcatheter arterial ***,not all patients with intermediate HCC benefit from transcatheter arterial ***,it is meaningful to propose a novel staging system of intermediate HCC in order to allocate different treatments for different *** et al proposed the first subclassification system of intermediate ***,investigators performed studies to validate the feasibility of Bolondi’s criteria and proposed several novel staging *** present study reviewed the literatures and provided a general overview of the evolution and current status of the subclassification of intermediate *** propose to expand the indication of liver resection and add radical treatments as the first option of the treatment for patients with intermediate HCC.

关键词： Subclassification intermediate hepatocellular carcinoma Treatment Staging Transcatheter arterial chemoembolization Liver resection

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Liver resection for intermediate hepatocellular carcinoma

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World Journal of Hepatology 2016年第14期8卷 607-615页

作者： Peng-Sheng Yi Ming Zhang Ji-Tong Zhao Ming-Qing Xu Department of Liver Surgery West China Hospital Sichuan University Department of Gynecology and Obstetrics West China Second Hospital Sichuan University

hepatocellular carcinoma(HCC) is one of the most common malignant tumors in China. The Barcelona Clinic Liver Cancer(BCLC) staging system is regarded as the gold standard staging system for HCC, classifying HCC as early, intermediate, or advanced. For intermediate HCC, trans-catheter arterial chemoembolization(TACE) is recommended as the optimal strategy by the BCLC guideline. This review investigates whether liver resection is better than TACE for intermediate HCC. Based on published studies, we compare the survival benefits and complications of liver resection and TACE for intermediate HCC. We also compare the survival benefits of liver resection in early and intermediate HCC. We find that liver resection can achieve better or at least comparable survival outcomes compared with TACE for intermediate HCC; however, we do not observe a significant difference between liver resection and TACE in terms of safety and morbidity. We conclude that liver resection may improve the short- and long-term survival of carefully selected intermediate HCC patients, and the procedure may be safely performed in the management of intermediate HCC.

关键词： Trans-catheter arterial chemoembolization intermediate hepatocellular carcinoma Liver resection Prognostic factor

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