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第十届全国免疫学学术大会

作者： Jinqing Li Jing Xu Limin Zheng State Key Laboratory of Oncology in South China Cancer Center Sun Yat-sen (Zhongshan) University State Key Laboratory of Biocontrol School of Life Sciences Sun Yat-sen (Zhongshan) University

interleukin-25(IL-25)is a newly described proinflammatory cytokine in the IL-17 *** role of IL-25 during tu-mor progression is poorly *** study aimed to investigate the cellular source and clinical significance of IL-25 in gastric cancer(GC)in *** and immunofluorescence were used to identify IL-25-expressing cells in GC *** analysis and Cox proportional hazards regression models were applied to estimate overall survival in 106 GC ***,flow cytometry,cell immunofluorescence and western blotting were performed to demonstrate the expression of IL-25 in ***(Mφs)were the main producers of IL-25 in GC tissues in situ,and the production of IL-25 in tumor-associated macrophages(TAMs)could be regulated by transforming growth factor-β1(TGF-β1)in ***-25+cells were highly enriched in the intra-tumoral regions(T)rather than the non-tumoral regions(N)of GC tissues(p25+T cells was positively associated with histological grade(p25+cells was positively associated with the density of CD4+T cells,CD8+T cells and CD20+B cells in the intra-tumoral region(all p25,may modulate local tumor milieu towards an anti-tumor immunity,and IL-25-producing Mφs could serve as a potential prognostic marker for GC patients.

关键词： interleukin-25 macrophages transforming growth factor-β1 gastric cancer

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窄谱中波紫外线对特应性皮炎患者外周血血清胸腺基质淋巴细胞生成素、白细胞介素25及其受体的影响

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中华皮肤科杂志 2015年第8期48卷 551-554页

作者：李玉娟江勇李慧卿王秀敏天津医科大学第二医院皮肤科 300211 山东省博兴县第二人民医院滨州医学院附属医院皮肤科

目的：探讨窄谱中波紫外线（NB-UVB）对特应性皮炎（AD）患者血清胸腺基质淋巴细胞生成素（TSLP）、白细胞介素25（IL-25）及外周血单一核细胞（PBMC）TSLP 受体（TSLPR）mRNA、IL-25受体（IL-25R） mRNA 表达水平的影响。方法 AD 患者4... 详细信息

目的：探讨窄谱中波紫外线（NB-UVB）对特应性皮炎（AD）患者血清胸腺基质淋巴细胞生成素（TSLP）、白细胞介素25（IL-25）及外周血单一核细胞（PBMC）TSLP 受体（TSLPR）mRNA、IL-25受体（IL-25R） mRNA 表达水平的影响。方法 AD 患者40例，采用 NB-UVB 照射治疗，双抗体夹心酶联免疫吸附试验（ELISA）检测治疗前后血清中 TSLP、IL-25水平；反转录-聚合酶链反应（RT-PCR）法检测治疗前后 PBMC TSLPR mRNA、IL-25R mRNA 的表达水平。采用欧洲的 AD 评分标准（SCORAD）评估疾病严重程度，视觉模拟标尺法（VAS）评价瘙痒程度。选取30例健康体检者作为对照。组间比较采用两独立样本 t 检验，治疗前后比较采用配对 t 检验。结果患者组经 NB-UVB 照射后总有效率达75%（30/40），治疗后 SCORAD 评分（20.36±5.12）及 VAS 评分（3.05±1.02）均较治疗前（分别为55.26±10.88和8.20±1.37）明显降低，差异均有统计学意义（t 值分别为10.29和8.16，P 〈0.05）。AD 患者组治疗前血清 TSLP [（198.24±29.47）ng/L]、IL-25含量（160.54±34.89 ng/L）及 TSLPR mRNA（8.57±1.34）、IL-25R mRNA（6.81±0.50）相对表达量均明显高于健康对照组[分别为（120.13±19.65）ng/L、（120.41±43.07）ng/L、1.94±0.39、1.48±0.47]，差异均有统计学意义（t 值分别为29.70、14.65、7.07、18.89，P 〈0.05）。NB-UVB 治疗显著改善病情后，患者血清 TSLP[（151.87±14.78） ng/L]、IL-25含量[（130.52±29.65）ng/L]及 PBMC TSLPR mRNA（2.89±0.53）、IL-25R mRNA（3.90±0.37）相对表达量较治疗前明显降低，差异均有统计学意义（t 值分别为18.56、9.07、5.21、7.35，均 P 〈0.05）。治疗后血清TSLP、IL-25含量，PBMC TSLPR mRNA、IL-25R mRNA 相对表达量与健康对照组相比，差异均无统计学意义（P 〉0.05）。结论 TSLP、IL-25可能在 AD 的发病中起重要作用，NB-UVB 下调 TSLP、IL-25及其受体的表达可能是 NB-UVB 治疗 AD 的机制之一。

关键词：皮炎,特应性紫外线胸腺基质淋巴细胞生成素白细胞介素 25 interleukin-25

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Better therapy for combat injury

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Military Medical Research 2020年第1期7卷 122-124页

作者： Yong-Ming Yao Hui Zhang Trauma Research Center Fourth Medical Center of the Chinese PLA General HospitalBeijing 100048People's Republic of China

In modern warfare,therapy for combat injury is a critical issue to improve personnel survival and battle *** limited to the severe circumstance in the distant battlefield,quick and effective treatment cannot be supplied that leads infections,sepsis,multiple organ dysfunction syndrome(MODS)and high *** get a better therapy for combat injury,we summarized several reports that associated with the mechanisms of sepsis and MODS,those published on MMR *** and colleagues reported gender difference in the outcomes of trauma,shock and *** advantageous outcome in female is due to their hormone *** accumulating reports indicated estrogen as a beneficial factor for multiple system and organs,including the central nervous system,the cardiopulmonary system,the liver,the kidneys,the immune system,and leads to better survival from *** et *** the underlying mechanisms in trauma induced sepsis,which can be concluded as an imbalance of immune response triggered by damage-associated molecular patterns(DAMPs)and other immune modifying *** also emphasize immunomodulation as a better therapeutic strategy that might be a potential benefit in regulating the host immune *** et *** revealed a crucial mechanism underlying lung epithelial and macrophage crosstalk,which involves IL-25 as a *** the injury,lung epithelial secreted IL-25 promotes TNF-αproduction in macrophage leading to acute lung injury(ALI).In addition to a mountain of cytokines,mitochondrial dysfunction in immune cell is another critical risk factor for immune dysfunction during *** morphology and function alterations in mitochondria are closely associated with inadequate ATP production,insufficient metabolism process and overloaded ROS production,which lead harm to immune cells and other tissues by triggering oxidative *** the above reports discussed mechanisms of sepsis induction after trauma and provided evide

关键词： Combat injury Sepsis Multiple organ dysfunction syndrome Estrogen Immune dysfunction Mitochondrial function interleukin-25

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Changes of the cytokine profile in inflammatory bowel diseases

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World Journal of Gastroenterology 2012年第41期18卷 5848-5861页

作者： Gyrgyi Mzes Béla Molnár Zsolt Tulassay Ferenc Sipos 2nd Department of Internal Medicine Semmelweis University1088 BudapestHungary Molecular Medicine Research Unit Hungarian Academy of Sciences1051 BudapestHungary

Cytokines are indispensable signals of the mucosaassociated immune system for maintaining normal gut *** imbalance of their profile in favour of inflammation initiation may lead to disease states,such as that is observed in inflammatory bowel diseases(IBD).Although Crohn's disease(CD) is often described as a prototype of T-helper 1-type diseases,and ulcerative colitis(UC) is traditionally viewed as a T-helper 2-mediated condition,the classic paradigm,which categorises cytokines into pro-and anti-inflammatory groups,has recently been *** inflammation regulatory pathways may not be mutually exclusive as individual cytokines can have diverse and even opposing functions in various clinical and immunological *** the less there are many common immunological responses in IBD that are mediated by *** they regulate and influence the development,course and recurrence of the inflammatory process,the concrete pathogenic role of these small signaling molecules is sometimes not unambiguous in the subtypes of the *** aim is to review the current information about pro-and anti-inflammatory effects of traditionally studied and recently discovered cytokines in the pathogenesis of UC and *** better understanding of their production and functional activity may lead to the development of new therapeutic modalities.

关键词： Ulcerative colitis Crohn's disease Interleu-kin-33 Tumor necrosis factor-like factor interleukin-8 interleukin-35 interleukin-25 interleukin-4 Tumornecrosis factor ligand superfamily member 14

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