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Melatonin attenuates acute pancreatitis-associated lung injury in rats by modulating interleukin 22

World Journal of Gastroenterology 2012年第36期18卷 5122-5128页

作者： Jia-Ping Huai Xue-Cheng Sun Meng-Jun Chen Yin Jin Xiao-Hua Ye Jian-Sheng Wu Zhi-Ming Huang Department of Gastroenterology First Affiliated Hospital of Wenzhou Medi- cal College Wenzhou 325000 Zhejiang Province China

AIM： To investigate whether therapeutic treatment with melatonin could protect rats against acute pan- creatitis and its associated lung injury. METHODS： Seventy-two male Sprague-Dawley rats were randomly divided into three groups： the sham op- eration （SO）, severe acute pancreatitis （SAP）, and mel- atonin treatment （MT） groups. Acute pancreatitis was induced by infusion of 1 mL/kg of sodium taurocholate （4% solution） into the biliopancreatic duct. Melatonin （50 mg/kg） was administered 30 min before pancre- atitis was induced, and the severity of pancreatic and pulmonary injuries was evaluated 1, 4 and 8 h after induction. Serum samples were collected to measure amylase activities, and lung tissues were removed to measure levels of mRNAs encoding interleukin 22 （IL-22） and T helper cell 22 （Th22）, as well as levels of *** IL-22 and Th22 were significantly higher （P 〈 0.001） in the MT group than in the SAP group （0.526 ± 0.143 vs 0.156 ± 0.027, respectively, here and throughout, after 1 h; 0.489 ± 0.150 vs 0.113 ± 0.014 after 4 h; 0.524 ± 0.168 vs 0.069 ± 0.013 after 8 h, 0.378 ± 0.134 vs 0.122 ± 0.015 after 1 h; 0.205 ± 0.041 vs 0.076 ± 0.019 after 4 h; 0.302 ± 0.108 vs 0.045 ± 0.013 after 8 h, respectively） and significantly lower （P 〈 0.001） in the SAP group than in the SO group （0.156 ± 0.027 vs 1.000 ± 0.010 after 1 h; 0.113 ± 0.014 vs 1.041 ± 0.235 after 4 h; 0.069 ± 0.013 vs 1.110 ± 0.213 after 8 h, 0.122 ± 0.015 vs 1.000 ± 0.188 after 1 h; 0.076 ± 0.019 vs 0.899 ± 0.125 after 4 h; 0.045 ± 0.013 vs 0.991 ± 0.222 after 8 h, respectively）. The mean pathologi- cal scores for pancreatic tissues in the MT group were significantly higher （P 〈 0.01） than those for samples in the SO group （1.088 ± 0.187 vs 0.488 ± 0.183 after 1 h, 2.450 ± 0.212 vs 0.469 ± 0.242 after 4 h; 4.994 ± 0.184 vs 0.513 ± 0.210 after 8 h）, but were significantly lower （P 〈 0.01） than those for samples in the SAP group at each time point （1.088 ± 0.187 vs 1.969 ± 0.290 after 1 h; 2.450 ±

关键词： interleukin 22 Melatonin Pancreatitis-associated lung injury Severe acute pancreatitis Thelper 22 cell

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IL-22 Suppresses the Infection of Porcine Enteric Coronaviruses by Activating STAT3 Signal Pathway

IL-22 Suppresses the Infection of Porcine Enteric Coronaviru...

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第十二届全国免疫学学术大会

作者： Liu Pinghuang Xue Mei Zhiao Jing Ma Yanlong Feng Li Harbin Veterinary Research Institute Qinghai University

Background:interleukin-22(IL-22),a member of the IL-10 superfamily,is primarily secreted by T helper 17 cells,innate lymphoid cells(ILC),innate natural killer(INK)cells,and epithelial ***-22 primarily targets nonhematopoietic epithelial cells and fibroblasts and plays essential roles in fighting against mucosal microbial infection and

关键词： interleukin 22 PEDV TGEV STAT3

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