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interferon α: the salvage therapy for patients with unsatisfactory response to minimal residual disease-directed modified donor lymphocyte infusion

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中华医学杂志(英文版) 2014年第14期127卷 2583-2587页

作者： Mo Xiaodong Zhao Xiangyu Xu Lanping Liu Daihong Zhang Xiaohui Chen Huan Wang Yu Huang Xiaojun Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Institute of HematologyPeople’s HospitalPeking University

Background Minimal residual disease(MRD)-directedmodified donor lymphocyte infusion(mDLI) is used to treat relapse after hematopoietic stem cell transplantation(HSCT). For patients who experience an unsatisfactory response tomDLI, relapse is usually inevitable. Therefore, we sought to evaluate the efficacy ofinterferon α therapy in these *** Regular MRD monitoring was carried out after the HSCT. The patients who were MRD-positive underwent mDLI. Patients with an unsatisfactory response to mDLI received interferon α therapy(3 million units, twice weekly) with regular monitoring of MRD. To ensure the immunomodulatory effects of interferon α, immunosuppressant treatment would be stopped before interferon α *** Five patients with an unsatisfactory response to mDLI treatment received interferon α(3 had t(8;21) chromosomal translocation acute myeloid leukemia, and 2 had common acute leukemia). They had significantly reduced or resolved MRD. Four patients developed chronic graft-versus-host disease. Two of the 5 patients reported transient fevers, and no significant bone marrow suppression was observed. All of them were in continuous complete remission after interferon α treatment. The median survival time was 469 days(range 368–948 days). Conclusions In patients with an unsatisfactory response to MRD-directed mDLI, interferon α may directly or indirectly induce the graft-versus-leukemia effect to improve mDLI efficacy and clear MRD.

关键词： interferon α hematopoietic stem cell transplantation donor lymphocyte infusion

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Diagnosis and management of interstitial pneumonitis associated with interferon therapy for chronic hepatitis C

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World Journal of Gastroenterology 2010年第35期16卷 4394-4399页

作者： Fan-Pu Ji Zheng-Xiao Li Hong Deng Hong-An Xue Yuan Liu Min Li Department of Dermatology Second Affiliated Hospital China Yuan Liu Department of Dermatology Second Afliated HospitalCollege of MedicineXi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina Department of Pulmonary Medicine Second Afliated HospitalCollege of MedicineXi’an Jiaotong University Xi’an 710004Shaanxi ProvinceChina Department of Imageology First Affiliated HospitalCollege of MedicineXi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

Interstitial pneumonitis(IP) is an uncommon pulmonary complication associated with interferon(IFN) therapy for chronic hepatitis C virus(HCV) *** can occur at any stage of HCV treatment,ranging from 2 to 48 wk,usually in the first 12 *** most common symptoms are dyspnoea,dry cough,fever,fatigue,arthralgia or myalgia,and anorexia,which are reversible in most cases after cessation of IFN therapy with a mean subsequent recovery time of 7.5 *** lavage in combination with chest high resolution computed tomography has a high diagnostic *** discontinuation of medication is the cornerstone,and corticosteroid therapy may not be essential for patients with mild-moderate pulmonary functional *** severity of pulmonary injury is associated with the rapid development of *** suggest that methylprednisolone pulse therapy followed by low dose prednisolone for a short term is necessary to minimize the risk of fatal pulmonary damage if signs of significant pulmonary toxicity occur in earlier *** should be aware of the potential pulmonary complication related to the drug,so that an early and opportune diagnosis can be made.

关键词： Chronic hepatitis C interferon α Interstitial pneumonitis Management Corticosteroid therapy

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Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 214-221页

作者： Swati Gupta Kamla Prasad Mishra Paban Kumar Dash Manmohan Parida Lilly Ganju Shashi Bala Singh Defence Institute of Physiology & Allied Sciences Defence Research and Development Establishment

Objective: To investigate the therapeutic efficacy of andrographolide, a plant derived compound, against chikungunya virus(CHIKV) infection. Methods: Using flow cytometry and immunoblotting assay, in vitro viral protein expression was studied in THP-1 cells line. In Balb/c mouse neonates, viral RNA copy number was determined by real time PCR. Results:The results showed reduced CHIKV protein expression on andrographolide treatment in CHIKV-infected human peripheral blood mononuclear cells, Vero cells and THP-I cell *** vivo, andrographolide treatment to CHIKV-infected neonates reduced viral RNA copy number. Further. andrographolide also increased cytotoxic T lymphocytes both in vitro and in vivo. Andrographolide also activated host innate immune pathways, viz., protein kinase *** eukaryotic initiation factor 2 α, retinoic acid inducible gene-Ⅰ and interferon regulatory factor 3/7, thereby increasing IFN-a secretion. CHIKV-induced nuclear factor κlight chain enhancer of activated B cells and tumor necrosis factor-a was also reduced on andrographolide treatment. Conclusion: Andrographolide inhibits CHIKV by suppressing viral protein expression and up-regulating host innate immunity and hence could be an effective therapeutic agent against CHIKV infection.

关键词： Chikungunya virus Andrographolide interferon α Protein kinase R Retinoic acid inducible gene-I Tumor necrosis factor α

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