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Adolescent stress increases depression-like behaviors and alters the excitatory-inhibitory balance in aged mice

Chinese Medical Journal 2019年第14期132卷 1689-1699页

作者： Hong-Li Wang Ya-Xin Sun Xiao Liu Han Wang Yu-Nu Ma Yun-Ai Su Ji-Tao Li Tian-Mei Si National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital/Institute of Mental Health)and the Key Laboratory of Mental Health Ministry of Health(Peking University)Beijing 100191China The Sixth People's Hospital of Hebei Province BaodingHebei 071000China

Background:Depression affects approximately 5% of elderly people and its etiology might be related to chronic stress exposure during neurodevelopmental periods.In this study,we examined the effects of adolescent chronic social stress in aged mice on depressive behaviors and the excitatory-inhibitory (E/I) balance in stress-sensitive regions of the brain.Methods:Sixty-four adolescent,male C57BL/6 mice were randomly assigned to either the 7-week (from post-natal days 29 to 77) social instability stress (stress group,n =32) or normal housing conditions (control group,n =32).At 15 months of age,16 mice were randomly selected from each group for a series of behavioral tests,including two depression-related tasks (the sucrose preference test and the tail suspension test).Three days following the last behavioral test,eight mice were randomly selected from each group for immunohistochemical analyses to measure the cell density of parvalbumin (PV+)-and calretinin (CR+)-positive gamma-aminobutyric-acid (GABA)ergic inhibitory inter-neurons,and the expression levels of vesicular transporters of glutamate-1 (VGIuT1) and vesicular GABA transporter (VGAT) in three stress-sensitive regions of the brain (the medial pre-frontal cortex [mPFC],hippocampus,and amygdala).Results:Behaviorally,compared with the control group,adolescent chronic stress increased depression-like behaviors as shown in decreased sucrose preference (54.96 ± 1.97% vs.43.11 ± 2.85%,t(22)=3.417,P =0.003) and reduced latency to immobility in the tail suspension test (92.77 ± 25.08 s vs.33.14 ± 5.95 s,t(25)=2.394,P =0.025),but did not affect anxiety-like behaviors and pre-pulse inhibition.At the neurobiologic level,adolescent stress down-regulated PV+,not CR+,inter-neuron density in the mPFC (F(1,39)=19.30,P inter-neuron density in the amygdala (F(1,28)=23.16,P 10.09,all P < 0.004),which suggests stress-induced hy

关键词： Adolescence Aging Depression inter-neuron Stress Vesicular glutamate transporter-1

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Neurodynamics analysis of brain information transmission

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Applied Mathematics and Mechanics(English Edition) 2009年第11期30卷 1415-1428页

作者：王如彬张志康 Chi K. Tse Institute for Cognitive Neurodynamics School of Information Science and EngineeringEast China University of Science and Technology Institute for Cognitive Neurodynamics School of Information Science and EngineeringEast China University of Science and Technology Department of Electronic and Information Engineering The Hong Kong Polytechnic UniversityKowloon

This paper proposes a model of neural networks consisting of populations of perceptive neurons, inter-neurons, and motor neurons according to the theory of stochastic phase resetting dynamics. According to this model, the dynamical characteristics of neural networks are studied in three coupling cases, namely, series and parallel coupling, series coupling, and unilateral coupling. The results show that the indentified structure of neural networks enables the basic characteristics of neural information processing to be described in terms of the actions of both the optional motor and the reflected motor. The excitation of local neural networks is caused by the action of the optional motor. In particular, the excitation of the neural population caused by the action of the optional motor in the motor cortex is larger than that caused by the action of the reflected motor. This phenomenon indicates that there are more neurons participating in the neural information processing and the excited synchronization motion under the action of the optional motor.

关键词： serial and parallel model of neural networks phase coding synchronousmotion perception neuron inter-neuron motor neuron population of neural oscillators

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