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Microvascular blood flow velocities measured with a retinal function imager: inter-eye correlations in healthy controls and an exploration in multiple sclerosis

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eye and Vision 2018年第1期5卷 260-268页

作者： Liang Wang Ohemaa Kwakyi James Nguyen Esther Ogbuokiri Olwen Murphy Natalia Gonzalez Caldito Laura Balcer Elliot Frohman Teresa Frohman Peter A.Calabresi Shiv Saidha Department of Neurology Johns Hopkins University School of MedicineBaltimoreMDUSA Departments of Neurology Population Health and OphthalmologyNew York University School of MedicineNew YorkNYUSA Departments of Neurology and Ophthalmology University of Texas Austin Dell Medical SchoolAustinTXUSA

Background:The retinal microcirculation has been studied in various diseases including multiple sclerosis(MS).However,inter-eye correlations and potential differences of the retinal blood flow velocity(BFV)remain largely unstudied but may be important in guiding eye selection as well as the design and interpretation of studies assessing or utilizing retinal *** primary aim of this study was to determine inter-eye correlations in BFVs in healthy controls(HCs).Since prior studies raise the possibility of reduced BFV in MS eyes,a secondary aim was to compare retinal BFVs between MS eyes,grouped based on optic neuritis(ON)history and HC ***:Macular arteriole and venule BFVs were determined using a retinal function imager(RFI)in both eyes of 20 *** eye from a total of 38 MS patients comprising 13 eyes with ON(MSON)and 25 eyes without ON(MSNON)history were similarly imaged with ***:OD(right)and OS(left)BFVs were not significantly different in arterioles(OD:3.95±0.59 mm/s;OS:4.08±0.60 mm/s,P=0.10)or venules(OD:3.11±0.46 mm/s;OS:3.23±0.52 mm/s,P=0.06)in *** strong inter-eye correlations were also found between arteriolar(r=0.84,Peyes were significantly lower than in HC eyes(P=0.009 and P=0.005,respectively).Similarly,arteriolar(3.59±0.69 mm/s)and venular(2.80±0.45 mm/s)BFVs in MSON eyes were also significantly lower than in HC eyes(P=0.046 and P=0.048,respectively).Arteriolar and venular BFVs in MSON and MSNON eyes did not differ from each other(P=0.42 and P=0.48,respectively).Conclusions:inter-eye arteriolar and venular BFVs do not differ significantly in HCs and are strongly *** findings support prior observations that arteriolar and venular BFVs may be reduced in MS ***,this seems to be the case in both MS eyes with and without a history of ON,raising the possibility of global blood flow alterations in ***

关键词： inter-eye correlation Blood flow velocity Retinal function imager Neurology Multiple sclerosis Optic neuropathy

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