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Identification of integrin β6 gene promoter and analysis of its transcription regulation in colon cancer cells

World Journal of Gastrointestinal Oncology 2020年第5期12卷 526-534页

作者： Wei Niu Qi-Yu Bo Jun Niu Zheng-Chuan Niu Cheng Peng Xue-Qing Zou Zhao-Yang Zhang Department of Hepatobiliary Surgery Qilu HospitalShandong UniversityJinan 250012Shandong ProvinceChina Department of Nursing Qilu HospitalShandong UniversityJinan 250012Shandong ProvinceChina Department of Emergency Surgery Qilu HospitalShandong UniversityJinan 250012Shandong ProvinceChina

BACKGROUND The integrinβ6 gene,which is expressed in epithelial cancer,plays a pivotal role in various aspects of cancer *** present research for integrinβ6 regulation mainly focuses on the post-transcription and translation related regulation mechanism and its role in *** mechanisms of how the integrinβ6 gene is regulated transcriptionally,and the promoter and transcription factors responsible for basic transcription of integrinβ6 gene remain *** To clone and characterize the integrinβ6 *** Software analysis was used to predict the region of integrinβ6 *** reporter plasmids,which contained the integrinβ6 promoter,were *** deletion analysis was performed to identify the location of core promoter and binding sites for transcription *** The regulatory elements for the transcription of the integrinβ6 gene were located between-286 and-85 and contained binding sites for transcription factors such as STAT3 and *** For the first time,we found the region ofβ6 core promoter and demonstrated the binding sites for transcription factors such as Ets-1 and STAT3,which are important for integrinβ6 promoter transcription *** findings are important for investigating the mechanism of integrinβ6 activation in cancer progression.

关键词： integrinβ6 integrinβ6 promoter Regulatory elements Transcription factors Colon cancer cell

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