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integrated gradient tissue-engineered osteochondral scaffolds:Challenges,current efforts and future perspectives

Bioactive Materials 2023年第2期20卷 574-597页

作者： Xiaolian Niu Ning Li Zhipo Du Xiaoming Li Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China Department of Orthopedics The Fourth Central Hospital of Baoding CityBaoding072350China

The osteochondral defect repair has been most extensively studied due to the rising demand for new therapies to diseases such as *** engineering has been proposed as a promising strategy to meet the demand of simultaneous regeneration of both cartilage and subchondral bone by constructing integrated gradient tissue-engineered osteochondral scaffold(IGTEOS).This review brought forward the main challenges of establishing a satisfactory IGTEOS from the perspectives of the complexity of physiology and microenvironment of osteochondral tissue,and the limitations of obtaining the desired and required ***,we comprehensively discussed and summarized the current tissue-engineered efforts to resolve the above challenges,including architecture strategies,fabrication techniques and in vitro/in vivo evaluation methods of the ***,we highlighted the advantages and limitations of various fabrication techniques of IGTEOS,and common cases of IGTEOS ***,based on the above challenges and current research progress,we analyzed in details the future perspectives of tissue-engineered osteochondral construct,so as to achieve the perfect reconstruction of the cartilaginous and osseous layers of osteochondral tissue *** comprehensive and instructive review could provide deep insights into our current understanding of IGTEOS.

关键词： osteochondral tissue engineering integrated gradient tissue-engineered osteochondral scaffold(IGTEOS) tissue-engineered strategies Fabrication techniques Evaluation

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