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Pancreatic neuroendocrine tumor with hypoglycemia and elevated insulin-like growth factor ii:a case report

Journal of Cancer Metastasis and Treatment 2016年第1期2卷 345-347页

作者： Roberta Modica Antonella Di Sarno Annamaria Colao Antongiulio Faggiano Department of Clinical Medicine and Surgery Federico II University80131 NaplesItaly UOC of Oncology A.O.Dei ColliMonaldi Unit80131 NaplesItaly Thyroid and Parathyroid Surgery Unit Istituto Nazionale per lo studio e la cura dei tumori“Fondazione G.Pascale”-IRCCS80131 NaplesItaly

Pancreatic neuroendocrine tumors(pNETs)can be associated with different clinical syndromes.insulinoma is the most common functioning pNET characterized by hypoglycemia and hyperinsulinemia.The authors report a case of a man presenting with hypoglycemia and biochemical features of insulinoma.A pancreatic lesion was found and growth hormone(GH)deficiency was also diagnosed associated with an empty sella present on the pituitary magnetic resonance imaging.The disappearance of hypoglycemia and normalization of GH secretion after surgical resection of the pancreatic lesion,revealed a rare pNET secreting insulin-like growth factor ii.

关键词： Pancreatic neuroendocrine tumor insulinoma hypoglycemia insulin-like growth factor ii

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EXPRESSION OF insulin-like growth factor Ⅱ(IGF-Ⅱ)IN HUMAN HEPATOCELLULAR CARCINOMA AND LIVER CIRRHOSIS:ITS RELATIONSHIP WITH HEPATITIS B VIRUS X PROTEIN EXPRESSION

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Chinese Journal of Cancer Research 1996年第3期8卷 9-14页

作者：张劲风苏勤贺晓慧刘彦仿

Sixty cases of hepatocellular carcinoma (HCC) and 47 cases of liver cirrhosis (LC) were examined with immunocytochemistry method using antibodies against IGF-ii and HBxAg on formalin-fixed, paraffin-embedded tissue sections. 32 HCC and 37 LC were found to be positive to HBxAg, in which the positive rates of IGF-ii were 100% (32/32) and 94.6% (35/37) respectively. 28 HCC and 10 LC were found to be HBxAg negative, IGF-ii was positive in 23 HCC (83.1%) and 6 LC (60%). The positive expression rates of IGF-ii in HBxAg positive tissues were significantly higher than those in HBxAg negative tissues (Pii expression in HCC and LC: (1) perinucleus; (2) diffuse in cytoplasm; (3) inside nucleus. IGF-ii was highly expressed in most of hyperplastic and neoplastic nodules hepatocytes and some of regeneration nodules. Small polygonal liver cells (SPLCs) were found in the liver tissues surrounding the tumor and cirrhosis and they were positive to both IGF-ii and HBxAg. The positive rates of IGF-ii in SPLC were 86.4% (38/44) in the HBxAg-positive tissues and 40.5%, (15/37) in the HBxAg-negative tissues. The above findings suggest that IGF-ii plays an important role in abnormal proliferation of HCC and SPLC. The relation between IGF-ii andHBxAg and the nature of SPLCs are also discussed.

关键词： Liver neoplasms Liver cirrhosis insulin-like growth factor ii Hepatitis B virus antigens Immuno-cytochemistry.

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Late-onset non-islet cell tumor hypoglycemia: A case report

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World Journal of Clinical Cases 2021年第1期9卷 163-169页

作者： Shunichi Matsumoto Eijiro Yamada Yasuyo Nakajima Naoki Yamaguchi Takashi Okamura Toshiki Yajima Satoshi Yoshino Kazuhiko Horiguchi Emi Ishida Masashi Yoshikawa Jun Nagaoka Sho Sekiguchi Mai Sue Shuichi Okada Izumi Fukuda Ken Shirabe Masanobu Yamada Department of Medicine and Molecular Science Gunma University Graduate School of MedicineMaebashi 371-8511GunmaJapan Division of General Thoracic Surgery Integrative Center of General SurgeryGunma University HospitalMaebashi 371-8511GunmaJapan Department of Endocrinology Diabetes and MetabolismGraduate School of Medicine Nippon Medical SchoolTokyo 1138602Japan

BACKGROUND Hypoglycemia due to non-insulin-producing tumors is referred to as non-islet cell tumor hypoglycemia(NICTH).As NICTH is a rare lesion,the natural course of NICTH is not well understood.We report a case of NICTH that was observed 30 years before the onset of hypoglycemia.CASE SUMMARY A 50-year-old man was diagnosed with an abnormal right chest shadow during a routine X-ray examination,but no further examination was undertaken because the lesion appeared benign.Thirty years after the tumor discovery,the patient was admitted to the hospital with symptoms of severe hypoglycemia,which was diagnosed as NICTH based on a complete examination.The tumor was resected and found to be a solitary fibrous mass(15.6 cm×13.7 cm×10.4 cm);thereafter,the patient’s blood glucose levels normalized and he completely recovered.CONCLUSION NICTH can have an acute onset,even if the tumor has been present and asymptomatic over a long time period.

关键词： Hypoglycemia Non-islet cell tumor hypoglycemia Blood glucose Solitary tumor Late onset Case report insulin-like growth factor ii

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