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Precise assembly of inside-out cell membrane camouflaged nanoparticles via bioorthogonal reactions for improving drug leads capturing

引用

Acta Pharmaceutica Sinica B 2023年第2期13卷 852-862页

作者： Xiaolin Zhang Xueyan Zhen Yixuan Yang Quan Feng Wanqing Yuan Xiaoyu Xie School of Pharmacy Health Science CenterXi'an Jiaotong UniversityXi'an 710061China Shaanxi Engineering Research Center of Cardiovascular Drugs Screening&Analysis Xi'an 710061China

cell membrane camouflaged nanoparticles have been widely used in the field of drug leads discovery attribute to their unique biointerface targeting ***,random orientation of cell membrane coating does not guarantee effective and appropriate binding of drugs to specific sites,especially when applied to intracellular regions of transmembrane *** reactions have been rapidly developed as a specific and reliable method for cell membrane functionalization without disturbing living ***,inside-out cell membrane camouflaged magnetic nanoparticles(IOCMMNPs)were accurately constructed via bioorthogonal reactions to screen small molecule inhibitors targeting intracellular tyrosine kinase domain of vascular endothelial growth factor *** functionalized cell membrane acted as a platform for specific covalently coupling with alkynyl functionalized magnetic Fe_(3)O_(4)nanoparticles to prepare *** inside-out orientation of cell membrane was successfully verified by immunogold staining and sialic acid quantification ***,two compounds,senkyunolide A and ligustilidel,were successfully captured,and their potential antiproliferative activities were further testified by pharmacological *** is anticipated that the proposed inside-out cell membrane coating strategy endows tremendous versatility for engineering cell membrane camouflaged nanoparticles and promotes the development of drug leads discovery platforms.

关键词： cell membrane camouflaged nanoparticles inside-out cell membrane coating Bioorthogonal reactions Drug leads discovery Traditional Chinese medicine Magnetic nanoparticles Precise assembly Alkynyl functionalization

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