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Global elimination of hepatitis C virus infection:Progresses and the remaining challenges

World Journal of Hepatology 2017年第33期9卷 1239-1252页

作者： Reza Taherkhani Fatemeh Farshadpour the Persian Gulf Tropical Medicine Research Center Bushehr University of Medical SciencesBushehr ***Iran

Today, with the introduction of interferon-free direct-acting antivirals and outstanding progresses in the prevention, diagnosis and treatment of hepatitis C virus(HCV) infection, the elimination of HCV infection seems more achievable. A further challenge is continued transmission of HCV infection in high-risk population specially injecting drug users(IDUs) as the major reservoir of HCV infection. Considering the fact that most of these infections remain undiagnosed, unidentified HCVinfected IDUs are potential sources for the rapid spread of HCV in the community. The continuous increase in the number of IDUs along with the rising prevalence of HCV infection among young IDUs is harbinger of a forthcoming public health dilemma, presenting a serious challenge to control transmission of HCV infection. Even the changes in HCV genotype distribution attributed to injecting drug use confirm this issue. These circumstances create a strong demand for timely diagnosis and proper treatment of HCV-infected patients through risk-based screening to mitigate the risk of HCV transmission in the IDUs community and, consequently, in the society. Meanwhile, raising general awareness of HCV infection, diagnosis and treatment through public education should be the core activity of any harm reduction intervention, as the root cause of failure in control of HCV infection has been lack of awareness among young drug takers. In addition, effective prevention, comprehensive screening programs with a specific focus on high-risk population, accessibility to the new anti-HCV treatment regimens and public education should be considered as the top priorities of any health policy decision to eliminate HCV infection.

关键词： Hepatitis C virus Epidemiology Elimination injecting drug user Prevention Vaccine Diagnosis Treatment

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Lurking epidemic of hepatitis C virus infection in Iran: A call to action

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World Journal of Hepatology 2017年第24期9卷 1040-1042页

作者： Reza Taherkhani Fatemeh Farshadpour the Persian Gulf Biomedical Research Center Bushehr University of Medical Sciences the Persian Gulf Tropical Medicine Research Center Bushehr University of Medical Sciences

Despite having a relatively low prevalence in the Iranian general population, the burden of hepatitis C virus(HCV) infection is on the rise, and hepatitis C is predicted to be the most important leading cause of viral hepatitis-related mortality in the near future in Iran. The recent population-based epidemiological studies have revealed the predominant role of injecting drug use in increasing prevalence of HCV infection. Undoubtedly, new management paradigm is required to drive down the rising wave of hepatitis C in Iran. Priority should be given to young injecting drug users as the cornerstone of the lurking epidemic of HCV infection in Iran.

关键词： General population injecting drug user Epidemiology Hepatitis C virus Iran

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