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Incisional Negative Pressure Wound Therapy in the Prevention of Surgical Site Infection after Vascular Surgery with inguinal incisions: Rationale and Design of a Randomized Controlled Trial (INVIPS-Trial)

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Surgical Science 2015年第12期6卷 562-571页

作者： Julien Hasselmann Tobias Kühme Jonas Bjork Stefan Acosta Vascular Center Skane University HospitalMalmoSweden Division of Occupational and Environmental Medicine Lund UniversityLundSweden

Background/Aims: inguinal incisions are a common route of access in vascular surgery. Due to anatomical challenges and a diverse bacterial flora in this area, surgical site infections (SSI) represent a common, debilitating and sometimes life-threatening complication. The INVIPS-Trial evaluates the role of Negative Pressure Wound Therapy (NPWT) on closed inguinal incisions in elective vascular surgery to prevent SSI and other wound complications. Methods: This randomized controlled trial (RCT) registered at *** (Identifier: NCT01913132) compares the effects of a NPWT dressing (PICO, Smith & Nephew, UK) and the center’s standard wound dressing (Vitri Pad, ViTri Medical, Sweden) on postoperative wound complications, especially SSI. The study includes two distinct vascular procedures with different SSI risk profiles: endovascular aortic repair (EVAR) and open surgical approaches involving the common femoral artery (OPEN). Results: Four hundred ninety-five groin incisions in both treatment arms are anticipated to be included in the EVAR group and 147 inguinal incisions in both treatment arms in the OPEN group. Since a large percentage of inguinal vascular procedures in both groups but especially in the EVAR group are performed bilaterally, many patients can serve as their own control by randomly receiving NPWT on one and the standard dressing on the contralateral inguinal incision. Conclusions: This ongoing RCT attempts to elucidate the potential benefit of NPWT on closed inguinal incisions after different vascular procedures. Outcome and conclusions of this trial could have implications on postoperative wound care of patients in both vascular surgery and other surgical specialties.

关键词： Incisional Negative Pressure Wound Therapy Vascular Surgery inguinal incisions Surgical Site Infection Randomized Controlled Trial Research Design

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