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Early therapeutic interventions of traditional Chinese medicine in COVID-19 patients:A retrospective cohort study

Journal of Integrative Medicine 2021年第3期19卷 226-231页

作者： Miao-yan Shi Shi-qi Sun Wei Zhang Xing Zhang Gui-hua Xu Xuan Chen Zi-jian Su Xiu-ming Song Lu-jiong Liu Yi-bao Zhang Yi-le Zhang Meng Sun Qi Chen Yan Xue Hua Lü Wei-an Yuan Xiao-rong Chen Yun-fei Lu Department of Respiratory Disease Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Center for Clinical Effect Evaluation Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Department of Clinical Pharmacology Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Shanghai Public Health Clinical Center Fudan UniversityShanghai 201508China

Objective:To observe the early interventions of traditional Chinese Medicine(TCM)on the conversion time of nucleic acid in patients with coronavirus disease 2019(COVID-19),and find possible underlying mechanisms of ***:A retrospective cohort study was conducted on 300 confirmed COVID-19 patients who were treated with TCM,at a designated hospital in *** patients were categorized into three groups:TCM1,TCM2 and TCM3,who respectively received TCM interventions within 7,8–14,and greater than15 days of *** indicators such as the conversion time of pharyngeal swab nucleic acid,the conversion time of fecal nucleic acid,length of hospital stay,and inflammatory markers(leukocyte count,and lymphocyte count and percentage)were analyzed to observe the impact of early TCM interventions on these ***:The median conversion times of pharyngeal swab nucleic acid in the three groups were 5.5,7 and16 d(P<0.001),with TCM1 and TCM2 being statistically different from TCM3(P<0.01).TCM1(P<0.05)and TCM3(P<0.01)were statistically different from *** median conversion times of fecal nucleic acid in the three groups were 7,9 and 17 d(P<0.001).Conversion times of fecal nucleic acid in TCM1 were statistically different from TCM3 and TCM2(P<0.01).The median lengths of hospital stay in the three groups were 13,16 and 21 d(P<0.001).TCM1 and TCM2 were statistically different from TCM3(P<0.01);TCM1 and TCM3 were statistically different from TCM2(P<0.01).Both leucocyte and lymphocyte counts increased gradually with an increase in the length of hospital stay in TCM1 group patients,with a statistically significant difference observed at each time point in the group(P<0.001).Statistically significant differences in lymphocyte count and percentage in TCM2(P<0.001),and in leucocyte count(P=0.043)and lymphocyte count(P=0.038)in TCM3 were *** comparison among the three groups showed a statistically significant difference in lymphocyte percentage o

关键词： Coronavirus disease 2019 Early interventions Traditional Chinese medicine Conversion time of viral nucleic acid inflammatory indicators

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