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LncRNA Airsci increases the inflammatory response after spinal cord injury in rats through the nuclear factor kappa B signaling pathway

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Neural Regeneration Research 2021年第4期16卷 764-769页

作者： Tao Zhang Kang Li Zi-Lu Zhang Kai Gao Chao-Liang Lv School of Clinical Medicine Jining Medical UniversityJiningShandong ProvinceChina Department of Orthopedics Jining No.1 People’s HospitalJiningShandong ProvinceChina

Spinal cord injury(SCI)is a serious traumatic event to the central nervous *** show that long non-coding RNAs(lncRNAs)play an important role in regulating the inflammatory response in the acute stage of ***,we investigated a new lncRNA related to spinal cord injury and acute *** analyzed the expression profile of lncRNAs after SCI,and explored the role of lncRNA Airsci(acute inflammatory response in SCI)on recovery following acute *** rats were divided into the control group,SCI group,and SCI+lncRNA Airsci-siRNA *** expression of inflammatory factors,including nuclear factor kappa B[NF-κB(p65)],NF-κB inhibitor IκBαand phosphorylated IκBα(p-IκBα),and the p-IκBα/IκBαratio were examined 1–28 days after SCI in rats by western blot *** differential lncRNA expression profile after SCI was assessed by RNA *** differentially expressed lncRNAs were analyzed by bioinformatics *** differentially expressed lncRNA Airsci,which is involved in NF-κB signaling and associated with the acute inflammatory response,was verified by quantitative real-time ***(IL-1β),IL-6 and tumor necrosis factor(TNF-α)at 3 days after SCI were measured by western blot assay and quantitative real-time *** histopathology of the spinal cord was evaluated by hematoxylin-eosin and Nissl *** function was assessed with the Basso,Beattie and Bresnahan Locomotor Rating *** differentially expressed lncRNAs were detected after SCI,including 151 that were upregulated and 186 that were downregulated in the SCI 3 d group compared with the control *** Airsci was the most significantly expressed among the five lncRNAs involved in the NF-κB signaling *** Airsci-siRNA reduced the inflammatory response by inhibiting the NF-κB signaling pathway,alleviated spinal cord tissue injury,and promoted the recovery of motor function in SCI *** findings show that numerous lncRNAs are differentially expres

关键词： apoptosis functional recovery inflammatory response long non-coding RNA neuroprotection NF-κB signaling pathway RNA sequencing spinal cord injury

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The cellular immunotherapy of integrated photothermal anti-oxidation Pde Se nanoparticles in inhibition of the macrophage inflammatory response in rheumatoid arthritis

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Acta Pharmaceutica Sinica B 2021年第7期11卷 1993-2003页

作者： Chuping Zheng Aiping Wu Xinyun Zhai Hong Ji Zhikang Chen Xu Chen Xiyong Yu Key Laboratory of Molecular Target&Clinical Pharmacology and the State Key Laboratory of Respiratory Disease Pharmacological Group School of Pharmaceutical Sciences&the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou 511436China The First Affiliated Hospital Jinan UniversityGuangzhou 510632China Nankai University School of Materials Science&EngineeringTianjin Key laboratory of Rare earth materials&applicationsCenter of Rare earth&Inorganic functional materialsTianjin 300350China

Reducing the inflammatory response is a major goal in the therapy of rheumatoid arthritis(RA).Herein,we integrated palladium nanoparticles(Pd NPs)with selenium nanoparticles(Se NPs)and obtained a multiple nanosystem(Pd@Se-HA NPs)that could simultaneously scavenge hydroxyl radicals(·OH)and provide a photothermal *** Pd@Se-HA NPs were constructed by a simple selfassembly method in which Se NPs were electrostatically bonded to Pd NPs;hyaluronic acid(HA)was linked to the NPs by ester bonding to provide macrophage targeting *** experiments show that the combined therapy of eliminating·OH with Se NPs and utilizing PTT with Pd NPs could effectively reduce the inflammatory response in macrophages more effectively than either individual NP *** addition,the outer layer of HA could specifically target the CD44 receptor to enhance the accumulation of Pd@Se NPs at the lesion,further enhancing the therapeutic *** treatment for 15 days,the Pd@Se-HA NPs nearly eliminated the inflammatory response in the joints of mice in an induced RA model,and prevented joint damage and degradation.

关键词： Rheumatoid arthritis inflammatory response Photothermal therapy Anti-oxidation therapy Core-shell structure

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Improvement of inflammatory response and gastrointestinal function in perioperative of cholelithiasis by Modified Xiao-Cheng-Qi decoction

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World Journal of Clinical Cases 2023年第4期11卷 830-843页

作者： Bao-Fang Sun Fan Zhang Qiang-Pu Chen Qiang Wei Wen-Tao Zhu Hai-Bin Ji Xing-Yuan Zhang Department of Hepatobiliary Surgery Binzhou Medical University HospitalBinzhou 256603Shandong ProvinceChina

BACKGROUND In the perioperative period of biliary surgery,various factors can induce the release of a large number of inflammatory factors,leading to an imbalance in proinflammatory and anti-inflammatory responses and resulting in gastrointestinal(GI)*** Recovery After Surgery protocols in biliary surgery have been shown to reduce the stress response and accelerate postoperative *** is crucial to reduce the inflammatory response and promote the recovery of GI function after biliary surgery,both of which are the basis and key for perioperative care and postoperative *** To better understand the effects of Modified Xiao-Cheng-Qi decoction(MXD)on inflammatory response and GI function in the perioperative management of cholelithiasis and their *** This was a prospective randomized placebo-controlled trial,in which 162 patients who received biliary tract surgery were randomly assigned to three groups:MXD group,XD group,and placebo-control *** observed parameters included frequency of bowel sounds,time of first flatus and defecation,time of diet,and amount of activity after *** serum levels of C-reactive protein(CRP),interleukin(IL)-6,IL-10,serum amyloid A protein(SAA),and substance P were measured by the enzyme-linked immunosorbent ***,the spearman correlation coefficient was used to analyze the relationship between the indicators of GI function and *** Compared to the placebo-control,improvements in GI function were observed in the MXD groups including reduced incidence of nausea,vomiting,and bloating;and earlier first exhaust time,first defecation time,and feeding time after surgery(P<0.05).On the 1st and 2nd d after surgery,IL-6,CRP and SAA levels in MXD group were lower than that in placebo control,but substance P level was higher,compared to the control(P<0.05).Functional diarrhea occurred in both MXD and XD groups without any other adverse effects,toxic reactions,and allergic re

关键词： Modified Xiao-cheng-qi Decoction Cholelithiasis inflammatory response Gastrointestinal function Enhanced Recovery After Surgery Perioperative

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Correlation between the neuroendocrine axis,microbial species,inflammatory response,and gastrointestinal symptoms in irritable bowel syndrome

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World Journal of Gastroenterology 2024年第35期30卷 3985-3995页

作者： Xin Zhang Wei-Wei Jin Hong-Gang Wang Department of Gastroenterology Tongde Hospital of Zhejiang ProvinceTaizhou 524333Zhejiang ProvinceChina Department of Nutrition Tongde Hospital of Zhejiang ProvinceTaizhou 524333Zhejiang ProvinceChina Department of Gastroenterology Taizhou Municipal HospitalTaizhou 524333Zhejiang ProvinceChina

BACKGROUND This study examines the complex relationships among the neuroendocrine axis,gut microbiome,inflammatory responses,and gastrointestinal symptoms in patients with irritable bowel syndrome(IBS).The findings provide new insights into the pathophysiology of IBS and suggest potential therapeutic targets for improving patient *** To investigate the interactions between the neuroendocrine axis,gut microbiome,inflammation,and gastrointestinal symptoms in patients with *** Patients diagnosed with IBS between January 2022 and January 2023 were selected for the *** individuals undergoing routine check-ups during the same period served as the control *** were collected on neuroendocrine hormone levels,gut microbiome profiles,inflammatory biomarkers,and gastrointestinal symptomatology to analyze their interrelations and their potential roles in IBS *** IBS patients exhibited significant dysregulation of the neuroendocrine axis,with altered levels of cortisol,serotonin,and neuropeptides compared to healthy *** gut microbiome of IBS patients showed reduced diversity and specific alterations in bacterial genera,including Bifidobacterium,Lactobacillus,and Faecalibacterium,which were associated with neuroendocrine ***,elevated levels of inflammatory markers,such as C-reactive protein,interleukin-6,and tumor necrosis factor-α,were observed and correlated with the severity of gastrointestinal symptoms like abdominal pain,bloating,and altered bowel *** The findings suggest that targeting the neuroendocrine axis,gut microbiome,and inflammatory pathways may offer novel therapeutic strategies to alleviate symptoms and improve the quality of life in IBS patients.

关键词： Gastrointestinal symptoms inflammatory response Intestinal microbiota Irritable bowel syndrome Neuroendocrine axis Relationship study

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Comparison of clinical efficacy and postoperative inflammatory response between laparoscopic and open radical resection of colorectal cancer

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World Journal of Clinical Cases 2022年第13期10卷 4042-4049页

作者： Long-Hai He Bo Yang Xiao-Qin Su Yue Zhou Zhen Zhang Department of General Surgery The First People’s Hospital of Wanzhou DistrictChongqing 404040China Department of Clinical Nutrition The First People’s Hospital of Wanzhou DistrictChongqing 404040China

BACKGROUND In recent years,the incidence of colorectal cancer(CRC)has increased annually,which has seriously threatened the health and quality of life of *** the treatment of CRC,both laparoscopic and radical resection are widely *** To explore and discuss clinical efficacy and postoperative inflammatory response of laparoscopic and open radical resection of *** A total of 96 patients with CRC diagnosed in our hospital from March 2016 to April 2021 were selected,and were divided into the study group(n=48)and control group(n=48)using a simple random *** control group was treated with open radical resection of CRC,and the study group was treated with laparoscopic radical resection of *** perioperative conditions(operation time,intraoperative blood loss,the recovery time of gastrointestinal function,number of lymph node dissections and length of hospital stay),inflammatory response index levels[interleukin(IL)-6,IL-8,IL-10,C-reactive protein(CRP)]before and after operation,pain stress response indices[levels of neuropeptide(NPY),prostaglandin E2(PGE2),5-hydroxytryptamine(5-HT)],and the incidence of the complications between the two groups were *** The operation time in the study group was(186.18±33.54 min),which was longer than that of the control group(129.38±26.83 min),but the intraoperative blood loss(111.34±21.45 mL),recovery time of gastrointestinal function(25.35±4.55 h),and hospital stay(10.09±2.38 d)were better than those in the control group(163.77±32.41 mL,36.06±7.13 h,13.51±3.66 d)(P0.05).There was no significant difference between the levels of serum IL-6(9.79±4.11 ng/mL),IL-8(3.79±1.71 ng/L),IL-10(48.96±12.51 ng/L)and CRP(7.98±2.33 mg/L)in the study group and the control group(10.56±3.78 ng/mL,4.08±1.45 ng/L,50.13±11.67 ng/L,8.29±2.60 mg/L)before the operation(P

关键词： Laparoscope Open surgery Colorectal cancer inflammatory response Pain stress response

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Gan Shen Fu Fang ameliorates liver fibrosis in vitro and in vivo by inhibiting the inflammatory response and extracellular signalregulated kinase phosphorylation

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World Journal of Gastroenterology 2020年第21期26卷 2810-2820页

作者： Qing-Hong Du Chu-Jun Zhang Wei-Hong Li Yan Mu Ya Xu Scott Lowe Lin Han Xue Yu Shu-Yan Wang Yu Li Jian Li Department of Histology and Embryology School of Traditional Chinese MedicineBeijing University of Chinese MedicineBeijing 102488China Institute of Tibetan Medicine University of Tibetan MedicineLhasa 850000Tibet Autonomous RegionChina School of Nursing Beijing University of Chinese MedicineBeijing 102488China School of Molecular and Cellular Biology University of IllinoisUrbana-ChampaignIL 61820United States

BACKGROUND Liver fibrosis is a common health problem worldwide and there is still a lack of effective *** Chinese herbal medicine,Gan Shen Fu Fang(GSFF)is composed of salvianolic acid B and diammonium *** this study,we observed the effects of GSFF on liver fibrosis in vivo and in vitro in an attempt to provide some hope for the *** To observe the effects of GSFF on liver fibrosis in vivo and in vitro and investigate the mechanism from the perspective of the inflammatory response and extracellular signal-regulated kinase(ERK)*** Common bile duct-ligated rats were used for in vivo *** stellate cells-T6(HSC-T6)cells were used for in vitro *** and eosin staining and Masson staining,biochemical assays,hydroxyproline(Hyp)assays,enzyme-linked immunoasorbent assay and western blotting were performed to evaluate the degree of liver fibrosis,liver function,the inflammatory response and ERK *** CCK8 assay,immunofluorescence and western blotting were applied to test the effect of GSFF on HSC-T6 cell activation and determine whether GSFF had an effect on ERK phosphorylation in HSC-T6 *** GSFF improved liver function and inhibited liver fibrosis in common bile ductligated rats after 3 wk of treatment,as demonstrated by histological changes,hydroxyproline assays and collagen I *** alleviated inflammatory cell infiltration and reduced the synthesis of pro-inflammatory cytokines[tumor necrosis factor-α(TNF-α)and interlukin-1β]and NF-κ*** addition,GSFF decreased ERK *** vitro,GSFF inhibited the viability of HSC-T6 cells with and without transforming growth factorβ1(TGF-β1)stimulation and decreased the synthesis of collagen *** had the greatest effect at a concentration of 0.5μmol/*** inhibited the expression ofα-smooth muscle actin(α-SMA),a marker of HSC activation,in HSC-T6 *** with the in vivo results,GSFF also inhib

关键词： Liver fibrosis Gan Shen Fu Fang inflammatory response Extracellular signal-regulated kinase phosphorylation In vivo In vitro

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Ki20227 aggravates apoptosis,inflammatory response,and oxidative stress after focal cerebral ischemia injury

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Neural Regeneration Research 2022年第1期17卷 137-143页

作者： Cheng Jiang Ze-Ning Wang Yu-Chen Kang Yi Chen Wei-Xin Lu Hai-Jun Ren Bo-Ru Hou Department of Neurosurgery Lanzhou University Second HospitalLanzhouGansu ProvinceChina Institute of Neurology Lanzhou UniversityLanzhouGansu ProvinceChina Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina

The survival of microglia depends on the colony-stimulating factor-1 receptor(CSF1R)signaling pathway under physiological ***20227 is a highly selective CSF1R inhibitor that has been shown to change the morphology of ***,the effects of Ki20227 on the progression of ischemic stroke are *** this study,male C57 BL/6 mouse models of focal cerebral ischemic injury were established through the occlusion of the middle cerebral artery and then administered 3 mg/g Ki20227 for 3 successive *** results revealed that the number of ionized calcium-binding adaptor molecule 1/bromodeoxyuridine double positive cells in the infarct tissue was reduced,the degree of edema was increased,neurological deficits were aggravated,infarct volume was increased,and the number of peri-infarct Nissl bodies was *** number of terminal deoxynucleotidyl transferase dUTP nick-end labeling-positive cells in the peri-infarct tissue was *** expression levels of Bax and Cleaved caspase-3 were ***-2 expression was *** expression levels of inflammatory factors and oxidative stress-associated factors were *** findings suggested that Ki20227 blocked microglial proliferation and aggravated the pathological progression of ischemia/reperfusion injury in a transient middle cerebral artery occlusion *** study was approved by the Animal Ethics Committee of Lanzhou University Second Hospital(approval No.D2020-68)on March 6,2020.

关键词： apoptosis colony-stimulating factor-1 receptor inflammatory response ischemia/reperfusion Ki20227 microglia oxidative stress transient middle cerebral artery occlusion

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inflammatory response-based subtyping and potential therapeutic strategies for triple-negative breast cancer

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Reproductive and Developmental Medicine 2023年第3期7卷 156-165页

作者： Ze-Qing Li Wen-Juan Zhang YI-Zhou Jiang Zhi-Ming Shao Ding Ma Jiong Wu Department of Breast Surgery Fudan University Shanghai Cancer CenterShanghai 200032China Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterShanghai 200032China Department of OncologyShanghai Medical College Fudan UniversityShanghai 200032.China

objective:inflammatory response plays a crucial role in the development and treatment of ***,the role of inflammatory response in triple-negative breast cancer(TNBC)remains *** on the heterogeneity of the inflammatory response,we classified TNBC,elucidated its subtype features,and revealed potential therapeutic ***:We established inflammatory response subtyping based on the RNA sequencing data of TNBCs derived from a cohort at the Fudan University Shanghai Cancer Center(FUSCC).Next,we explored the features and potential therapeutic strategies for each subgroup by analyzing transcriptome *** a machine-learning method,we validated and generalized the TNBC inflammatory response subtypes in an external ***:A total of 360 TNBC samples and 88 normal tissues were collected from a cohort at *** with TNBC were divided into four inflammatory response groups(IRGs)based on the expression of inflammatory response genes:high inflammatory response gene expression with pronounced pyroptosis phenotype and high immune cellinfiltration(IRG 1),low inflammatory response gene expression and low immune cell infiltration(IRG 2),ITGB8 specific inflammatory response with a predominant proliferation phenotype(IRG 3),and low M1/M2 ratio with a marked angiogenesis phenotype(IRG 4).Relapse-free survival(RFS)was better in iRG 1 and 2 and worse in IRG 3 and *** to their poor prognosis,we mainly focused on IRG 3 and IRG 4 to investigate potential treatment ***8 was highly expressed in IRG 3;thus,targeting ITGB8 may be a potential therapeutic strategy for patients in IRG *** 4 had a lower M1/M2 ratio and a marked angiogenesis phenotype;therefore,therapeutic strategies,such as anti-angiogenesis or M2 to M1 repolarization of macrophages,could be recommended for these ***,we validated and generalized the TNBC inflammatory response subtyping in an external dataset using a machine-learning ***

关键词： inflammatory response Triple-negative breast cancer Precise treatment

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Bisphenol AP Exposure-Induced inflammatory response in Zebrafish Embryos Revealed by Transcriptomic Analysis

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Environment & Health 2024年第6期2卷 373-380页

作者： Qingjiang Ding Hailin Wang State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China School of Environment Hangzhou Institute for Advanced StudyUCASHangzhou 310024China University of Chinese Academy of Sciences Beijing 100049China

Bisphenol AP(BPAP)is a bisphenol analogue that is used as a substitute for BPA in industrial production and is now commonly found in the ***,there is limited information available on its developmental toxicity in aquatic *** study exploited zebrafish embryos to investigate the adverse effects of BPAP exposure during their early life *** results revealed that BPAP had a median lethal concentration(LC_(50))of 36,22,and 8.5μmol/L for zebrafish embryos at 24,48,and 72 h post fertilization(hpf),***,exposure to BPAP led to abnormal development in zebrafish embryos,including hatching delay,malformation,and inhibition of spontaneous *** analysis further revealed that BPAP exposure upregulated the mRNA expression levels of genes related to inflammatory pathways,such as il1b,ptgs2b,and fosab,indicating the induction of an inflammatory ***,our findings provide early and valuable insights into the environmental and health risks associated with BPAP exposure.

关键词： Bisphenol AP Zebrafish inflammatory response RNA-seq Embryonic development

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Mufangji tang ameliorates pulmonary arterial hypertension through improving vascular remodeling,inhibiting inflammatory response and oxidative stress,and inducing apoptosis

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Traditional Medicine Research 2024年第2期9卷 52-65页

作者： Yu-Ming Wang Hong-Wei Tao Feng-Chan Wang Ping Han Na Liu Guo-Jing Zhao Hai-Bo Hu Xue-Chao Lu College of Traditional Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Respiratory and Critical Care Medicine Qingdao Hospital of Traditional Chinese Medicine(Qingdao Hiser hospital)Qingdao 266000China.

Background:Mufangji tang(MFJT)is composed of Ramulus Cinnamomi,Radix Ginseng,Cocculus orbiculatus(Linn.)DC.,and *** clinical settings,MFJT has been effectively employed in addressing a range of respiratory disorders,notably including pulmonary arterial hypertension(PAH).However,the mechanism of action of MFJT on PAH remains ***:In this study,a monocrotaline-induced PAH rat model was established and treated with *** therapeutic effects of MFJT on PAH rat model were *** pharmacology was conducted to screen the possible targets for MFJT on PAH,and the molecular docking between the main active components and the core targets was carried *** key targets identified from network pharmacology were ***:Results showed significant therapeutic effects of MFJT on PAH rat *** of network pharmacology revealed several potential targets related to apoptosis,inflammation,oxidative stress,and vascular *** docking showed that the key components were well docked with the core *** experimental validation results that MFJT treatment induced apoptosis(downregulated Bcl-2 levels and upregulated Bax levels in lung tissue),inhibited inflammatory response and oxdative stress(decreased the levels of IL-1β,TNF-α,inducible NOS,and malondialdehyde,and increased the levels of endothelial nitric oxide synthase,nitric oxide,glutathione and superoxide dismutase),reduced the proliferation of pulmonary arterial smooth muscle cells(downregulated ET-1 andβ-catenin levels and ERK1/2 phosphorylation,increased GSK3βlevels).Conclusion:Our study revealed MFJT treatment could alleviate PAH in rats via induction of apoptosis,inhibition of inflammation and oxidative stress,and the prevention of vascular remodeling.

关键词： Mufangji tang pulmonary arterial hypertension apoptosis inflammatory response oxidative stress vascular remodeling

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