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Nonlymphocyte-lymphocyte ratios as potential inflammatory markers for systemic autoimmune rheumatic diseases

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Nonlymphocyte-lymphocyte ratios as potential inflammatory ma...

Novel diagnostics for aggravating pancreatic fistulas at the acute phase after pancreatectomy

第十二届全国免疫学学术大会

作者： Liang Yan SHI Hong WANG Hao Zhou Lin Zhong RENQIAN Department of Laboratory Diagnostics Changzheng HospitalSecond Military Medical University

Objective:To evaluate neutrophil-(NLR),monocyte-(MLR),eosinophil-(ELR) and basophil-lymphocyte ratios(BLR)in systemic autoimmune rheumatic diseases(SARDs).Methods:A total of 1139 SARD patients and 170 healthy individuals were enrolled,x-test was used to compare difference between *** were plotted and AUCs were calculated to assess differentiating performance of nonlymphocyte-lymphocyte ratios between one SARD and ***:(1) NLR was ssignificantly higher in SARD patients than in healthy *** was higher in most SARD patients except OA than in healthy *** was significantly decreased in SLE patients,but increased in other SARD patients,compared with healthy *** was lower in most SARD patients except PM/DM and PMR than healthy controls.(2) NLR,MLR,ELR and BLR had some differentiating performance for some *** showed the largest AUC for differentiating SLE from other SARDs and healthy individuals.(3) Markedly higher levels of MLR and ELR in AS patients and of NLR and MLR in those with pSS,SSc and PMR were observed in male than in *** age significantly correlated with NLR,MLR and ELR in RA,with MLR and ELR in OA,with ELR and BLR in MCTD and with ELR in PMR.(4) In SLE,CRP showed positive correlation with NLR,MLR and *** significantly negatively correlated with NLR and positively with *** RA,AS and OA,NLR and MLR significantly positively correlated with ESR and *** pSS,ESR showed markedly positive correlation with NLR and MLR,while CRP,IgG and IgA did only with ***:The study demonstrated increased NLR and MLR and deceased BLR in most SARDs,decreased ELR in SLE and increased ELR in other *** and MLR may be useful tools to reflect inflammatory status of SARDs.

关键词： Nonlymphocyte-lymphocyte ratios rheumatic disease inflammatory marker

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World Journal of Gastroenterology 2014年第26期20卷 8535-8544页

作者： Mitsuro Ka Tsutomu Fujii Hideki Takami Masaya Suenaga Yoshikuni Inokawa Suguru Yamada Daisuke Kobayashi Chie Tanaka Hiroyuki Sugimoto Masahiko Koike Shuji Nomoto Michitaka Fujiwara Yasuhiro Kodera Department of Gastroenterological Surgery (Surgery Ⅱ) Nagoya University Graduate School of Medicine

AIM: To identify sensitive predictors of clinically relevant postoperative pancreatic fistula (POPF) at the acute phase after pancreatectomy.

关键词： Pancreatectomy Pancreatic fistula Prediction inflammatory marker C-reactive protein

Human Wharton’s jelly mesenchymal stem cells inhibit cytokine storm in acute respiratory distress syndrome in a rat model

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Asian Pacific Journal of Tropical Biomedicine 2022年第8期12卷 343-350页

作者： Wahyu Widowati Teresa Liliana Wargasetia Fanny Rahardja Rimonta F Gunanegara Didik Priyandoko Marisca Evalina Gondokesumo Ervi Afifah Cahyaning Riski Wijayanti Rizal Rizal Faculty of Medicine Maranatha Christian UniversityJl.Surya Sumantri no 65Bandung 40164Indonesia Faculty of Mathematic and Natural Science Education Indonesia University of EducationJl.Dr.Setiabudi no 229Bandung 40154Indonesia Faculty of Pharmacy University of SurabayaUniversitas SurabayaJl.Raya KalirungkutSurabaya 60293Indonesia Biomolecular and Biomedical Research Center Aretha Medika UtamaJl.Babakan Jeruk 2 no 9Bandung 40163Indonesia Biomedical Engineering Department of Electrical EngineeringFaculty of EngineeringUniversitas IndonesiaJl.Margonda RayaDepok 1642Indonesia

Objective:To evaluate the potential effect of human Wharton’s jelly mesenchymal stem cells(hWJMSCs)on acute respiratory distress syndrome in lipopolysaccharide(LPS)-induced ***:The hWJMSCs(5×10^(4)/mL,5×10^(5)/mL,5×10^(6)/mL)were administered to rats on day 1 and day 8 after being induced by LPS(5 mg/kg body weight).TNF-αlevels in the lung and IL-18 and IL-1βlevels in the serum were measured using *** addition,caspase-1 expression in lung tissues was quantified using qRT-PCR,and NF-κB and IL-6 expressions were assessed using ***:The hWJMSCs decreased TNF-αlevels in the lung and plasma IL-18 and IL-1β***,the hWJMSCs downregulated the expressions of caspase-1,IL-6,and NF-κB in lung ***:The hWJMSCs can decrease inflammatory markers of acute respiratory distress syndrome in a rat model and may be further investigated for the treatment of acute respiratory distress syndrome.

关键词： Human Wharton’s jelly mesenchymal stem cells Acute respiratory distress syndrome TNF-α IL-18 NF-κB inflammatory marker

Biological markers of Undernutrition and Risk of Complications in Children Hospitalized at the Teaching Hospital of Brazzaville

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Journal of Biosciences and Medicines 2022年第2期10卷 1-9页

作者： Christel Mikolélé-Bilombo Lucie Charlotte Atipo-Ibara Ollandzobo Steve Vassili Missambou Mandilou Thibaut Ocko Gokaba Lethso Clausina Mikolélé-Bilomb Ahoui Josué Simo Louokdom Martial Landry Miguel Etienne Mokondjimobe Donatien Moukassa Jean Robert Mabiala-Babela Ange Antoine Abena Jean-Rosaire Ibara Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Department of Pediatrics Teaching Hospital of Brazzaville Brazzaville Congo Department of Gastroenterology and Hepatology Teaching Hospital of Brazzaville Brazzaville Congo Cameroon Mountain University Douala Cameroon Denis Sassou Nguesso University Brazzaville Congo

Introduction: Undernutrition is a condition frequently encountered in pediatrics. It leads to an increased morbidity and mortality regardless of the underlying condition or other risk factors such as age. In countries with limited resources such as ours, the diagnosis of undernutrition is often limited to the clinical presentation, and the contribution of biology is not often taken into account. Objectives: To establish the relationship between anthropometric parameters and biological markers in the diagnosis and classification of undernutrition and to assess the risk of infectious complications during undernutrition in children. Materials and Methods: A cross-sectional study conducted in Brazzaville among undernourished children aged 1 - 59 months between October 2018 and April 2019. Clinical diagnosis was based on WHO growth charts. The CRP, orosomucoid, albumin and transthyretin were obtained using the Cobas c311 analyzer, which enabled the calculation of Prognostic inflammatory and Nutritional Index (PINI). The comparison of the means of the biological markers used the Student’s t-test, the risk of infectious complications the chi-square. The correlation of the diagnostic value of Z-score weight/height and PINI was also investigated. The significance level was set at 0.05. Results: Of the 95 children enrolled 63 (66.3%) were clinically severely malnourished, including 26 acute (41.3%) and 37 chronic (58.7%). The PINI revealed severe undernutrition in 85 children (89.4%) including 50 acute (58.8%) and 35 chronic (41.2%). CRP and orosomucoid were statistically higher in severe acute undernutrition (p Conclusion: Anthropometric parameters have a front-line advantage for assessing and classifying undernutrition. However, biological markers of undernutrition with PINI should be systematized in the diagnosis and management of undernutrition.

关键词： Undernutrition Nutritional marker inflammatory marker PINI Child Congo

Risk factors for development of pneumothorax in patients with COVID-19 at a government health facility in North India:An exploratory case-control study

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Journal of Acute Disease 2023年第6期12卷 238-243页

作者： Manabendra Baidya Sandeep Kumar Pandey Hariom Kumar Solanki Ankur Deep Singh Samaksh Giri Syed Altamash Government Institute of Medical Sciences Greater NoidaUttar PradeshIndia201310

Objective:To explore risk factors for the development of pneumothorax in patients with COVID-19 during the second COVID-19 wave at a northern Indian level 2 health ***:Patients suffering from SARS-CoV-2 infection during the second wave of the COVID-19 pandemic in India(January-June 2021)at a tertiary care teaching hospital and level 2 COVID care facility were *** who suffered from SARS-CoV-2 infection but did not develop pneumothorax were selected as matched *** details regarding demographics,clinical presentation,treatment,and outcome were recorded in a semi-structured ***:Eleven patients with COVID-19 developed pneumothorax during the study period and 40 controls were included in the *** cases were smokers in comparison to only two in the control *** 2 diabetes mellitus was the most common comorbidity among both *** change in C-reactive protein overall for cases and controls were around+14.0 and-41.9 and was statistically ***:inflammatory markers like C-reactive protein have significant correlations with the development of pneumothorax in COVID-19-infected *** is no sex predisposition to develop pneumothorax among patients with COVID-19.

关键词： COVID-19 Pneumothorax Chest tube Correlates Risk factors inflammatory marker C-reactive protein

Systemic immune-inflammation index:A predictor of major adverse cardiovascular events for patients with acute coronary syndrome

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South China Journal of Cardiology 2024年第3期25卷 142-148,155页

作者： QU Wei JIANG Ting-ting AN Zi-qiang XU Hai-jia Limin Hospital of Weihai High Distric Weihai City 264400Shandong ProvinceChina Songcun Health Center Wendeng DistrictWeihai City 264400Shandong ProvinceChina

Background Systemic immune-inflammation index(SII)has emerged as a potential marker for assessing inflammation and predicting outcomes in patients with acute coronary syndrome(ACS).However,its role in forecasting clinical prognosis in ACS patients undergoing primary coronary angiography remains *** This retrospective study included 657 ACS patients who underwent primary coronary angiography between January 2016 and January *** were divided into low and high SII groups based on the Youden index cut-off *** primary endpoint was the occurrence of major adverse cardiovascular events(MACEs),including nonfatal myocardial infarction(MI),nonfatal stroke,heart failure,target lesion revascularization(TLR),and cardiovascular ***-Meier survival analysis and Cox regression were performed to assess the association between SII and *** Patients with high SII had significantly higher rates of MACEs(25.7%vs.10.3%,P<0.001),including nonfatal MI,heart failure,and *** adjusting for conventional risk factors,SII remained an independent predictor of MACEs(HR:2.102,95%CI:1.616-3.011,P=0.002).Kaplan-Meier analysis confirmed poorer event-free survival in the high SII group(P=0.00093).Conclusions Elevated SII was associated with a higher risk of adverse outcomes in ACS patients,suggesting its potential utility as a comprehensive tool for risk stratification and prognosis in ACS patients.[S Chin J Cardiol 2024;25(3):142-148]

关键词： Acute coronary syndrome Systemic immune-inflammation index inflammatory marker Major adverse cardiovascular events

Novel molecular panel for evaluating systemic inflammation and survival in therapy naïve glioma patients

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World Journal of Clinical Oncology 2021年第10期12卷 947-959页

作者： Puneet Gandhi Richa Shrivastava Nitin Garg Sandeep K Sorte Department of Research Bhopal Memorial Hospital and Research CentreBhopal 462038Madhya PradeshIndia Department of Neurosurgery Bhopal Memorial Hospital and Research CentreBhopal 462038Madhya PradeshIndia

BACKGROUND Inflammation is crucial to tumor progression.A traumatic event at a specific site in the brain activates the signaling molecules,which triggers inflammation as the initial response within the tumor and its *** educated immune cells and secreted proteins then initiate the inflammatory cascade leading to persistent chronic ***,estimation of the circulating inflammatory indicators kynurenine(KYN),interleukin-6(IL-6),tissue-inhibitor of matrix-metalloproteinase-1 and human telomerase reverse transcriptase(hTERT)along with neutrophil-lymphocyte ratio(NLR)has prognostic *** To assess the utility of chosen inflammatory marker panel in estimating systemic *** The chosen markers were quantitatively evaluated in 90 naive,molecularly subtyped plasma samples of glioma.A correlation between the markers and confounders was assessed to establish their prognostication ***-up on the levels of the indicators was done 3-mo *** establish the validity of circulating KYN,it was also screened qualitatively by dot-immune-assay and by immunofluorescence-immunohistochemistry in tumor *** Median values of circulating KYN,IL-6,hTERT,tissue-inhibitor of matrixmetalloproteinase-1 and NLR in isocitrate-dehydrogenase-mutant/wildtype and within the astrocytic sub-groups were estimated,which differed from controls,reaching statistical significance(Pmarkers negatively correlated with mortality(P90%)than standalone markers,to define *** inflammatory panel could discriminate between WHO grades,and isocitrate-dehydrogenase-mutant/wildtype and define differential survival between astrocytic isocitrate-dehydrogenase-mutant/***,its assessment for precise disease prognosis is *** of KYN with NLR,IL-6 and hTERT was ***-regres

关键词： Circulating Glioma inflammatory marker Kynurenine Non-invasive Prognostic

The Impact of Coronavirus Disease 2019 (COVID-19) among Immune Compromised Patients in Augusta Victoria Hospital AVH-2021

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Advances in Infectious Diseases 2021年第3期11卷 269-277页

作者： Maen Hajmohammasd Rami Zighari Hammam Rjoup Tahreer Taha Sari Abu Hania Faeda Eqtait Bilal Shawamreh Yousef Hamamra Haitham Al-Amleh Murad Krajah Noor Ismael Ali Sabateen Augusta Victoria Hospital Jerusalem Palestine Arab American University Jenin Palestine

Background: Coronavirus disease 2019 which is officially known as COVID-19 belongs to family viruses. COVID-19 manifestations vary among affected people. These symptoms may become more serious among patients suffering from chronic disease and those who are on treatment which may af-fect their defense mechanism or immune-compromised patients who become more vulnerable to complications of COVID-19, and at high risk for morbidity and mortality with any bacterial or viral illness. Method: A retrospective, non-experimental research design was applied with a quantitative approach among patients with COVID-19 who were admitted to COVID-19 department at AVH with a total of 72 patients. Data were extracted from a patients’ elec-tronic medical record. Results: During COVID-19 outbreak 72 patients were admitted to COVID department at AVH, 54.2% were female and 33% of study participants were from Gaza governorate followed by Jerusalem 27%. Most participants 34.7% had first clinic visit after two days from the onset of COVID-19 symptoms. 45.8% were discharged to home while 13.9% died. All inflammatory markers that include ferritin, C-RP, IL-6 and D-dimer are in-creasing in all patients that were admitted to hospital;IL-6 and D-dimer were significant inflammatory markers in relation to the mortality rate. The study found the risk of mortality with IL-6 mean (218.5), and D-dimer mean (12). Furthermore there was a relation between increased risk of mortality and im-mune comprised. Conclusion: Mortality rate increased among COVID-19 pa-tients when IL-6 was higher than 218.5 and D-dimer higher than 12, and there was a relationship between increased risk of mortality and immune comprised.

关键词： Coronavirus Immune Compromised Augusta Victoria Hospital inflammatory marker Interleukin 6 Mortality

Enhancing effect of tazarotene on the HLA-DR expression of cultured human keratinocytes induced by interferon-gamma

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Journal of Medical Colleges of PLA(China) 2005年第2期20卷 91-93页

作者：张江安谭升顺 Department of Dermatology Second Hospital of Xi'an Jiaotong University

Objective: To investigate the effect of tazarotene on the expression of HLA-DR induced by IFN-γ. Methods: (1) Keratinocytes from normal human skin were cultured in vitro;(2) Tazarotene, IFN-γ and the combination of the two compounds were incubated with the keratinocytes in medium, respectively. The expression of HLA-DR in keratinocytes was determined using immunocytochemistry techniques at 24h after incubation. Results: (1) There was rare expression of HLA-DR in normal human keratinocytes; (2) 10 -6mol/L tazarotene failed to induce the expression of HLA-DR in keratinocytes at 24h after incubation; (3) 500 U/ml IFN-γ obviously induced the HLA-DR expression in keratinocytes at 24h after treatment; (4) After 24h, 10 -7-10 -5 mol/L tazarotene had a significantly enhancing effect on the expression of HLA-DR induced by IFN-γ (P<0.005). Conclusion: Tazarotene up-regulates the expression of HLA-DR in keratinocytes cultured in vitro when combined with IFN-γ . Therefore, the reduction of HLA-DR positive keratinocytes in psoriatic lesions may be attributed to not direct interaction of tazarotene in combination with IFN-γ but other pathways.

关键词： tazarotene interferon keratinocyte inflammatory marker