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inflammation scores predict survival for hepatitis B virus-related hepatocellular carcinoma patients after transarterial chemoembolization

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World Journal of Gastroenterology 2015年第18期21卷 5582-5590页

作者： Dong-Sheng Zhou Li Xu Yao-Ling Luo Feng-Ying He Jun-Ting Huang Yao-Jun Zhang Min-Shan Chen Department of Hepatobiliary Surgery Sun Yat-sen University Cancer Center Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Department of Clinical Laboratory Sun Yatsen University Cancer Center

AIM:To compare the prognostic ability of inflammation scores for patients with hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)undergoing transarterial chemoembolization(TACE).METHODS:Data of 224 consecutive patients who underwent TACE for unresectable HBV-related HCC from September 2009 to November 2011 were retrieved from a prospective *** association of inflammation scores with clinicopathologic variables and overall survival(OS)were analyzed,and receiver operating characteristic curves were generated,and the area under the curve(AUC)was calculated to evaluate the discriminatory ability of each inflammation score and staging system,including tumor-node-metastasis,Barcelona Clinic Liver Cancer,and Cancer of the Liver Italian Program(CLIP)***:The median follow-up period was 390 d,the one-,two-,and three-year OS were 38.4%,18.3%,and 11.1%,respectively,and the median OS was *** Glasgow Prognostic Score(GPS),modifed GPS,neutrophil-lymphocyte ratio,and Prognostic Index were associated with *** GPS consistently had a higher AUC value at 6 mo(0.702),12 mo(0.676),and24 mo(0.687)in comparison with other inflammation *** consistently had a higher AUC value at6 mo(0.656),12 mo(0.711),and 24 mo(0.721)in comparison with tumor-node-metastasis and Barcelona Clinic Liver Cancer staging *** analysis revealed that alanine aminotransferase,GPS,and CLIP were independent prognostic factors for *** combination of GPS and CLIP(AUC=0.777)was superior to CLIP or GPS alone in prognostic ability for ***:The prognostic ability of GPS is superior to other inflammation scores for HCC patients undergoing *** GPS and CLIP improved the prognostic power for OS.

关键词： Hepatocellular carcinoma inflammation-based prognostic score Prognostic index Staging system Transarterial chemoembolization

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