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Comparison of serum reproductive hormones, antioxidants, PGE2 and PGF2-α between primary and secondary infertile women in Calabar

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Asian pacific Journal of Reproduction 2017年第4期6卷 181-185页

作者： Idongesit K Isong Chinyere AO Usoro Zibril A Okhormhe Dorathy C Okpokam Christopher EJ Udiong Department of Medical Laboratory Science(Chemical Pathology Unit) University of CalabarCalabarNigeria Department of Medical Laboratory Science(Haematology/Blood Transfusion Unit) University of CalabarCalabarNigeria

Objective:To compare the prolactin, progesterone, luteinizing hormone, follicle stimulating hormone, estradiol, antisperm antibodies, tumor necrosis factorα, total antioxidant capacity, prostaglandin E2 and F2α between primary and secondary infertile women in Calabar.Methods:One hundred and two volunteers infertile women (test group), aged 20-45 years attending the infertility clinic in the University of Calabar Teaching Hospital (UCTH) were recruited. Fourteen of the women had primary infertility while 88 of them had secondary infertility. Sixty apparently healthy, age matched women served as the control group. Five millilitres of blood was collected, allowed to clot and serum was obtained from the subjects and Enzyme Linked Immunosorbent Assay method was used for prolactin, progesterone, estradiol, follicle stimulating hormone (FSH) and luteinizing hormone (LH), prostaglandin E2and F2α, human TNF-α,Chlamydia trachomatis IgG, antisperm antibodies assay, while serum total antioxidant capacity was assessed spectrophotometrically.Results:The result shows on comparison that primary infertile women has a significantly higher level of progesterone than those with secondary infertility (P>0.05). There was a significant difference in the levels of prolactin and total antioxidant capacity in the primary and secondary infertility when compare to the control group atP>0.05. Their mean ages were (31.10±5.37) years and (33.10±4.91) years respectively. There was a positive correlation between TAC and FSH, TNF and anti-sperm anti-bodies in the test group ofr=0.207 andr=0.632;P>0.05 respectively.Conclusions: These findings suggest no alterations in levels of prostaglandin F2α, TNF and anti-oxidant between primary and secondary infertile females.

关键词： Progesterone Estradiol Luteinizing hormone Follicle stimulating hormone infertile women

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Effect of cognitive behavioral therapy on anxiety and depression of infertile women: A meta-analysis

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Asian pacific Journal of Reproduction 2019年第6期8卷 251-259页

作者： Hossein Mashhadi Abdolahi Morteza Ghojazadeh Salman Abdi Mahdieh Abbasalizad Farhangi Zeinab Nikniaz Leila Nikniaz Tabriz Health Services Management Research Center Tabriz University of Medical SciencesTabrizIran Research Center for Evidence-Based Medicine Tabriz University of Medical SciencesTabrizIran Clinical Psychiatry Research Center Tabriz University of Medical SciencesTabrizIran Drug Applied Research Center Tabriz University of Medical SciencesTabrizIran Liver and Gastrointestinal Diseases Research Center Tabriz University of Medical SciencesTabrizIran

Objective:To investigate the effect of cognitive behavioral therapy on anxiety and depression in infertile women.Methods:This study was performed in 2019 by searching Google Scholar,Scopus,PubMed/MEDLINE,Cochrane library,EMBASE,Proquest,ISI Web of Science,MagIran,SID and IranMedex.Eligible studies were selected by two reviewers and outcomes of interest were extracted.The meta-analysis was performed using the random effect models.Ⅰ-square statistic test was used for heterogeneity analysis.Presence of publication bias was also checked.Results:Eleven studies were included in this review.Between-group differences(cognitive behavioral therapy and control groups)in risk ratio for infertile women's depression was d=-1.36;95%CI=-1.81,-0.90;Pinfertile women's anxiety,between-group differences in risk ratio wasd=-0.83;95%CI=-1.18,-0.47;P<0.001.Conclusions:Cognitive behavioral therapy is effective in the reduction of depression and anxiety in patients with or withoutin vitro fertilization/intracytoplasmic sperm injection treatment.However,the lack of high-quality studies makes it challenging to make a solid and precise conclusion.Well-designed studies should be undertaken in the future to confirm these results.

关键词： Cognitive behavioral therapy Anxiety Depression infertile women Meta-analysis

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Evaluation of infertile women: Mini-review

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Asian pacific Journal of Reproduction 2017年第1期6卷 4-8页

作者： Mohannad Abu Faza Ibrahim A Abdelazim Hossam S Osman Dareen A Alsharif Department of Obstetrics and Gynecology Ahmadi HospitalKuwait Department of Obstetrics and Gynecology Ain Shams UniversityEgypt

Evaluation of infertility indicated for women failed to conceive after one year of unprotected intercourse and for women over 35 years failed to conceive after 6 mo of unprotected intercourse, because the fertility decline as women approach 40 years. Evaluation of infertile couple should begin with semen analysis of male partner. If the semen analysis is within normal range, evaluation then move on to female partner. Evaluation of the infertile woman should be carried in cost-effective manner to identify the causes of infertility using the least invasive methods. Methods of evaluation of infertile women include: 1) history and physical examination;2) evaluation of the male partner;3) documentation of ovulation;4) evaluation of the ovarian reserve;5) evaluation of cervical causes of infertility;6) evaluation of uterine causes of infertility;7) documentation of the tubal patency;and 8) exclusion of peritoneal causes of infertility. Evaluation of infertile couple should include evaluation of both partners. Semen analysis for the male partner, followed by documentation of ovulation and evaluation of genital tract patency. PCT is not used as routine evaluation of infertile women. Laparoscopy is not used as routine evaluation of infertile women unless there is suspected peritoneal factors of infertility or endometriosis or tubal occlusion. Ovarian reserve should only be done for infertile women with diminished response to external gonadotropins (not routine).

关键词： infertile Women Mini-review

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Genome-wide identification of gene expression in the epididymis of infertile rat induced by alpha-chlorohydrin using oligonucleotide microarray

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沈阳药科大学学报 2008年第S1期25卷 111-112页

作者： XIE Shu-wu1,2,ZHU Yan1,2,MA Li1,2,LI Zhi-ling1,2,GUI You-lun1,2,LU Ying-ying3,ZHAO Zhi-fang1,2,CAO Lin1,2(1.Department of Reproductive Pharmacology,Shanghai Institute of Planned Parenthood Research 2.National population and family planning key laboratory of contraceptive drugs and devices,Shanghai 200032,China 3.Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200011,China)

Objective To establish a rat model of sterility associated with epididymis and epididymal gene expression profiles relation to fertility by alpha-chlorohydrin.Methods Rats were treated with 10 mg·kg-1·d-1.alpha-chlorohydrin for 10 consecutive days.Sperm maturation and other fertility parameters were analyzed.The sperm motility and morphology were evaluated by computer-assisted sperm analysis(CASA);sperm survival rate was assessed by SYBR-14 and propidium iodide(PI)fluorescent staining;the weights of testes,epididymides,prostates and seminal vesicles were determined by electronic balance;histological examination of above tissues were evaluated by HE staining;and serumal dihydrotestosterone(DHT)and testosterone(T)of rats were detected by enzyme-labeled immunoassay.Each male rat was paired with 2 female rats in proestrus.Female rats were examined the next morning for the presence of sperm in vaginal smears and underwent a cesarean section on day 12 of gestation.Finally the reproductive indices were calculated as follows:copulation index(number of sperm positive females /number of pairings),pregnancy index(number of pregnancies /number of sperm positive females),and fertility index(number of pregnancies /number of pairings).After that we used Affymetrix Rat 230 2.0 oligo-microarray to identify epididymal special genes associated with fertility.Finally,we validated some of these genes by Real-Time quantitative polymerase chain reaction.Results The motility of spermatozoa from the cauda epididymidis of treated rats showed a significant decrease in percentage of motile,progressively motile sperm,and sperm survival rate.At the same time,the morphology of cauda epididymal spermatozoa was also adversely affected by the treatment.In addition,the serumal androgen levels of treated animals weren't changed compared with the control group.Accordingly,matings with treated males resulted in no successful pregnancy.Then,we classified general functions of the down or up regulated epididymal genes by chlorhydrin with the GeneSpring

关键词： male infertile rat ACH antifertility agents oligonucleotide microarray

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Proteomic analysis reveals dysregulated cell sign aling in ejaculated spermatozoa from in fertile men

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Asian Journal of Andrology 2019年第2期21卷 121-130页

作者： Luna Samanta Rakesh Sharma Zhihong Cui Ashok Agarwal American Center for Reproductive Medicine Cleveland ClinicClevelandOH 44195USA Department of Zoology School of Life SciencesRavenshaw UniversityCuttackOdisha 753003India Institute of Toxicology The Third Military Medical UniversityChongqing 400038China

Dysfunctional sperm maturation is the primary reason for the poor sperm motility and morphology in infertile men.Spermatozoa from infertile men were fractioned on three-layer density gradient(80%,60%,and 40%).Fraction 1(Fl)refers to the least mature stage having the lowest den sity,whereas the fraction 4(F4)in eludes the most dense and morphologically mature motile spermatozoa.Fraction 2(F2)and fraction 3(F3)represent the intermediate stages.Proteins were extracted and separated by dimensional gel.Bands were digested with trypsin and analyzed on a LTQ-Orbitrap Elite hybrid mass spectrometer system.Functional annotations of proteins were obtained using bioinformatics tools and pathway databases.A total of 1585 proteins were detected in the four fractions of spermatozoa.A dysregulated protein turnover and protein folding may lead to accumulation of defective proteins or proteins that otherwise would have been eliminated during the process of maturation,resulting in the impairment of sperm fun ction.Aberra nt chaper one expressi on may be a major con tributing factor to the defective sperm function.Androge n receptor was predicted as a transcription regulator in one of the networks and the affected pathways were chaperone-mediated stress response,proteosomal pathway,and sperm function.The down regulation of key pathways and protei ns which compromises the fertilizi ng potential of spermatozoa may provide in sight into the mecha nisms that lead to male infertility.

关键词： androgen receptor chaperone immature sperm infertile men proteasome spermatozoa

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Happiness　for　infertile　Couples：　An　Introduction　to　Zhangzhou　Medical　Centre　for　Treatment　of　Infertility

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China Population Today 1996年第4期13卷 14-16页

作者： Jiang Huanming and Gao Mingjing

ＨａｐｐｉｎｅｓｓｆｏｒＩｎｆｅｒｔｉｌｅＣｏｕｐｌｅｓ：ＡｎＩｎｔｒｏｄｕｃｔｉｏｎｔｏＺｈａｎｇｚｈｏｕＭｅｄｉｃａｌＣｅｎｔｒｅｆｏｒＴｒｅａｔｍｅｎｔｏｆＩｎｆｅｒｔｉｌｉｔｙ￥ＢｙＪｉａｎｇＨｕａｎｍｉｎｇ... 详细信息

ＨａｐｐｉｎｅｓｓｆｏｒＩｎｆｅｒｔｉｌｅＣｏｕｐｌｅｓ：ＡｎＩｎｔｒｏｄｕｃｔｉｏｎｔｏＺｈａｎｇｚｈｏｕＭｅｄｉｃａｌＣｅｎｔｒｅｆｏｒＴｒｅａｔｍｅｎｔｏｆＩｎｆｅｒｔｉｌｉｔｙ￥ＢｙＪｉａｎｇＨｕａｎｍｉｎｇａｎｄＧａｏＭｉｎｇｊｉｎｇＴｈｅ...

关键词： infertile Happiness Couples Infertility Treatment An

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Seminal Fluid Characteristics of Men Attending Infertility Clinic of a Teaching Hospital

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Open Journal of Medical Microbiology 2013年第1期3卷 1-4页

作者： Festus Abiose Olajubu Deji-Agboola Mope Olubunmi Adetokunbo Osinupebi Olusoji Edward Jagun Department of Medical Microbiology & Parasitology Obafemi Awolowo College of Health Sciences Olabisi Onabanjo University Sagamu Nigeria Department of Medical Microbiology & Parasitology Obafemi Awolowo College of Health SciencesOlabisi Onabanjo University Sagamu Nigeria Department of Medical Microbiology & Parasitology Olabisi Onabanjo University Teaching Hospital Sagamu Nigeria Department of Obstetrics and Gynaecology College of Health Sciences Olabisi Onabanjo University Sagamu Nigeria

The semen quality of 479 men in infertile marriages, who attended the infertility clinic of OOUTH, Sagamu between May 2004 and April 2009 were analyzed. The semen samples were physically examined, microscopically analyzed and aerobically cultured. The result showed that out of 51.5% oligospermic cases recorded, 39.8% could be classified severe. Cryptozoospermia were diagnosed in 72 (15%) cases. Bacteriospermia and Necrozoospermia were found in 149 and 6 cases respectively. The predominant organism isolated was Staphylococcus aureus (50.32%) while Neisseria gonorrhoea was isolated in only 2 cases. Highest infection of 62.4% was noticed among the group with 1% - 19% motility. From the studied population, 8.8% were azoospermic. The commonest morphological defects were pin and ragged heads (48%). It is therefore obvious that the assessment of semen quality remains one of the important steps in infertility interventions.

关键词： Sperm Concentration OOUTH infertile Marriages Motility Bacteriospermia

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男性不育症精浆中超氧化物歧化酶、锌、睾酮含量的研究

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中国男科学杂志 1989年第1期10卷 1-5页

作者：李望霓陈华霖林毅郑晓红万启智熊惠芳吴东成都计划生育培训中心成都市计划生育技术指导所

本文采用一种简便灵敏的改良邻苯三酚法测定了236例不育症患者和27例正常育龄男子精浆中铜锌超氧化物歧化酶(CuZn-SoD)含量,同时还测定了精浆锌(Zn)和睾酮(T)含量。结果表明:在不育症精浆中,CuZn-SOD、Zn、T与精子密度之间均有显著正相... 详细信息

本文采用一种简便灵敏的改良邻苯三酚法测定了236例不育症患者和27例正常育龄男子精浆中铜锌超氧化物歧化酶(CuZn-SoD)含量,同时还测定了精浆锌(Zn)和睾酮(T)含量。结果表明:在不育症精浆中,CuZn-SOD、Zn、T与精子密度之间均有显著正相关(P<0.01);CuZn-SOD和Zn含量与精子活动度均有密切关系,含量高活动度也高(P<0.001);CuZn-SOD和Zn之间亦存在显著正相关(P<0.01). 在精子密度范围同60～100×10~6/ml时.不育组与生育组精浆中CuZn-SOD、Zn、T含量均无统计学差异(P<0.2).本究究提示.CuZn-SOD作为精浆保护因子,通过抑制类脂过氧化反应使精子免受损伤。精浆CuZn-SOD含量测定有可能作为衡量精液质量的新指标。应用SOD类制剂治疗男性不育症可能有裨益。

关键词： infertile men Seminal plasma Superoxide Dismutase(SOD) Zinc(Zn) Testosterone (T)

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Observations on the Treatment of PCOS by Combined Letrozole and Extracts of Pu'er Tea

Observations on the Treatment of PCOS by Combined Letrozole ...

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2014浙江省医学会医学遗传学学术年会

作者： Zhang Fan Zhang Chengcheng Jin Fan Department of Reproductive Endocrinology Key Laboratory of Reproductive GeneticsMinistry of Educationand Women’s Reproductive Health Laboratory of Zhejiang ProvinceWomen’s HospitalZhejiang University School of Medicine

Purpose:To evaluate the clinical efficiency of the PCOS induced infertile patients’resistance to CC after the treatment with the combined usage of Letrozole and Extracts of Pu er Tea.Methods:20 PCOS induced infertile patients who are resistant against to CC were randomly divided into two groups,and 10 patients in each group.A group:LE was taken for five days from the third day of the menstruation,5mg each time and once a day.B group:on the basis of A group,the patients had been taken the Extracts of Pu er Tea 10g every day for one month,which last for three month or till pregnancy.Meanwhile,on the tenth day of each menstruation,the B ultrasonic via vagina should be done to monitor the ovarian follicle and the uterine endometrium.Moreover,on the third day of menstruation,blood should be obtained for the detection of endocrine hormone.Results:After the treatment,the ovulation rates of patients in group A and group B are 60.00%and 80.00%respectively,and the pregnancy rates are40.00%and 70.00%.In general,both the ovulation rates and the pregnancy rates showed significant enhancement(P<0.01),and the patients in the two groups were found significant decreased levels of LH/FSH and T.Conclusion:After the combined usage of Letrozole and Extracts of Pu er Tea,the endocrinic condition of the patients has been improved,the ovulation successfully induced,and the pregnancy rate enhanced,all of which showed the Extracts of Pu er Tea had great clinical prospect and deserved prevalent application.

关键词： PCOS Letrozole resistance to Clomiphene critate infertile Extracts of Pu’er Tea

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45,X/46,X,r(Y)/46,X,dic r(Y) in an azoospermic male and literature review

45,X/46,X,r(Y)/46,X,dic r(Y) in an azoospermic male and lite...

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第十二次全国医学遗传学学术会议

作者： Yuan Dong Yu-Ting Jiang Xiao-Wei Yu Xiang-Yin Liu Lei-Lei Li Rui-Zhi Liu Center for Reproductive Medicine Center for Prenatal DiagnosisFirst HospitalJilin University Department of Cell Biology Norman Bethune College of Medicine Jilin University

Objective To analyze the phenotype and karyotype in an azoospermic male with r(Y). Methods Conventional cytogenetic karyotype analysis with GTG-bangding and Fluorescent in situ hybridization(FISH) were performed on metaphases chromosome.There-color FISH was performed using a probe containing CEP18/X/Y.Y chromosome microdeletion assay and SRY examinations were also performed by PCR.Results FISH confirmed that the ring chromosome was Y chromosome and the big ring was two Y chromosome.Y chromosome microdeletion assay showed no deletion in the azoospermia factor region.The SRY gene was also existed by PCR. Conclusion These results should be a causion that cytogenetic and molecular evaluations were necessary for azoospermic males before using advanced reproductive techniques.

关键词： Azoospermia Ring Y chromosome infertile Mosaic AZF SRY

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