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Responses from two firing patterns in inferior colliculus neurons to stimulation of the lateral lemniscus dorsal nucleus

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Neural Regeneration Research 2016年第5期11卷 787-794页

作者： Xiao-ting Li Ning-yu Wang Yan-jun Wang Zhi-qing Xu Jin-feng Liu Yun-fei Bai Jin-sheng Dai Jing-yi Zhao Department of Otorhinolaryngology Head and Neck Surgery Beijing Chaoyang Hospital Capital Medical University Department of Neurophysiology Capital Medical University

The γ-aminobutyric acid neurons（GABAergic neurons） in the inferior colliculus are classified into various patterns based on their intrinsic electrical properties to a constant current injection. Although this classification is associated with physiological function, the exact role for neurons with various firing patterns in acoustic processing remains poorly understood. In the present study, we analyzed characteristics of inferior colliculus neurons in vitro, and recorded responses to stimulation of the dorsal nucleus of the lateral lemniscus using the wholecell patch clamp technique. Seven inferior colliculus neurons were tested and were classified into two firing patterns： sustained-regular（n = 4） and sustained-adapting firing patterns（n = 3）. The majority of inferior colliculus neurons exhibited slight changes in response to stimulation and bicuculline. The responses of one neuron with a sustained-adapting firing pattern were suppressed after stimulation, but recovered to normal levels following application of the γ-aminobutyric acid receptor antagonist. One neuron with a sustained-regular pattern showed suppressed stimulation responses, which were not affected by bicuculline. Results suggest that GABAergic neurons in the inferior colliculus exhibit sustained-regular or sustained-adapting firing patterns. Additionally, GABAergic projections from the dorsal nucleus of the lateral lemniscus to the inferior colliculus are associated with sound localization. The different neuronal responses of various firing patterns suggest a role in sound localization. A better understanding of these mechanisms and functions will provide better clinical treatment paradigms for hearing deficiencies.

关键词： nerve regeneration inferior colliculus GABAergic neuron firing pattern sustained-regular firing pattern sustained-adapting firing pattern precedence effect long-lasting inhibition dorsal nucleus of the lateral lemniscus inhibitory projection neural regeneration

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Local inhibition of GABA affects precedence effect in the inferior colliculus

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Neural Regeneration Research 2014年第4期9卷 420-429页

作者： Yanjun Wang Ningyu Wang Dan Wang Jun Jia Jinfeng Liu Yan Xie Xiaohui Wen Xiaoting Li Department of Otorhinolaryngology Head and Neck Surgery Beijing Chaoyang HospitalCapital Medical University Department of Neurophysiology Capital Medical University

The precedence effect is a prerequisite for faithful sound localization in a complex auditory environment, and is a physiological phenomenon in which the auditory system selectively suppresses the directional information from echoes. Here we investigated how neurons in the inferior colliculus respond to the paired sounds that produce precedence-effect illusions, and whether their firing behavior can be modulated through inhibition with gamma-aminobutyric acid （GABA）. We recorded extracellularly from 36 neurons in rat inferior colliculus under three conditions： no injection, injection with saline, and injection with gamma-aminobutyric acid. The paired sounds that produced precedence effects were two identical 4-ms noise bursts, which were delivered contralaterally or ipsilaterally to the recording site. The normalized neural responses were measured as a function of different inter-stimulus delays and half-maximal interstimulus delays were acquired. Neuronal responses to the lagging sounds were weak when the inter-stimulus delay was short, but increased gradually as the delay was lengthened. Saline injection produced no changes in neural responses, but after local gamma-arninobutyric acid application, responses to the lagging stimulus were suppressed. Application of gamma-aminobutyric acid affected the normalized response to lagging sounds, independently of whether they or the paired sounds were contralateral or ipsilateral to the recording site. These observations suggest that local inhibition by gamma-aminobutyric acid in the rat inferior colliculus shapes the neural responses to lagging sounds, and modulates the precedence effect.

关键词： nerve regeneration precedence effect auditory center inferior colliculus gamma-amino-butyric acid local inhibition echo suppression lagging stimulus NSFC grant neural regeneration

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Cross-talk between NMDA and GABA_A receptors in cultured neurons of the rat inferior colliculus

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Science China(Life Sciences) 2011年第6期54卷 560-566页

作者： CONG DanNi TANG ZhengQuan LI LongZhu HUANG YiNa WANG Jun CHEN Lin Chinese Academy of Sciences Key Laboratory of Brain Function and Diseases School of Life SciencesUniversity of Science and Technology of ChinaHefei 230027China Auditory Research Laboratory University of Science and Technology of ChinaHefei 230027China Department of Anatomy and Neurobiology Northeastern Ohio Universities Colleges of Medicine and PharmacyRootstownOH 44272USA

Neuronal ion channels of different types often do not function independently but will inhibit or potentiate the activity of other types of channels,a process called *** N-methyl-D-aspartate receptor (NMDA receptor) and the γ-aminobutyric acid type A receptor (GABAA receptor) are important excitatory and inhibitory receptors in the central nervous system,***,cross-talk between the NMDA receptor and the GABAA receptor,particularly in the central auditory system,is not well *** the present study,we investigated functional interactions between the NMDA receptor and the GABAA receptor using whole-cell patch-clamp techniques in cultured neurons from the inferior colliculus,which is an important nucleus in the central auditory *** found that the currents induced by aspartate at 100 μmol L-1 were suppressed by the pre-perfusion of GABA at 100 μmol L-1,indicating cross-inhibition of NMDA receptors by activation of GABAA ***,we found that the currents induced by GABA at 100 μmol L-1 (IGABA) were not suppressed by the pre-perfusion of 100 μmol L-1 aspartate,but those induced by GABA at 3 μmol L-1 were suppressed,indicating concentration-dependent cross-inhibition of GABAA receptors by activation of NMDA *** addition,inhibition of IGABA by aspartate was not affected by blockade of voltage-dependent Ca2+ channels with CdCl2 in a solution that contained Ca2+,however,CdCl2 effectively attenuated the inhibition of IGABA by aspartate when it was perfused in a solution that contained Ba2+ instead of Ca2+ or a solution that contained Ca2+ and 10 mmol L-1 BAPTA,a membrane-permeable Ca2+ chelator,suggesting that this inhibition is mediated by Ca2+ influx through NMDA receptors,rather than voltage-dependent Ca2+ ***,KN-62,a potent inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII),reduced the inhibition of IGABA by aspartate,indicating the involvement of CaMKII in this *** s

关键词： inferior colliculus N-methyl-D-aspartate receptor γ-aminobutyric acid type A receptor whole-cell patch-clamp cross-talk

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Local inhibition mediated by γ-aminobutyric acid-A receptor and duration tuning in inferior colliculus in guinea pigs

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Journal of Otology 2007年第2期2卷 70-80页

作者： Renévan Wijhe Ear and Auditory Research Laboratory Dalhousie University Canada

Duration is a salient feature of acoustic signals including speech. Duration tuning was first reported in frogs and later in echolocating bats. More recently, duration tuning has been reported in non-echolocating mammals and appears to be a fundamental encoding mechanism throughout the animal kingdom. However, the duration tuning reported in these non-echolocating mammals appears to be much weaker than that in the previous studies on bats. In contrast to this finding, our recent study reported that duration tuning in the IC in guinea pigs appeared to be strong when it was measured using an appropriate temporal window. With such a temporal window, duration tuning was found to be compatible with that of echo-locating bats. In the present report, we further demonstrate that duration tuning in the IC of this species is established by interaction between excitation and GABAergic inhibition. In addition to overall increase in responsiveness, application of bicuculline(BIC), a GABA-A receptor antagonist, was found to significantly reduce or eliminate duration selectivity in 44 out of the 67 neurons that showed clear duration tuning from a sample of 340 neurons.

关键词： duration tuning inferior colliculus local inhibition

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PERIPHERAL HEARING LOSS CAUSES HYPEREXCITABILITY OF THE inferior colliculus

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Journal of Otology 2013年第1期8卷 39-43页

作者： Sun Wei Center forHearing&Deafness Departmentof Communicative Disorders and SciencesState University of New York at Buffalo

Growing evidence has been found to suggest that early development of the central auditory system is dependent on acoustic stimuli. Peripheral damage caused by noise exposure and ototoxic drugs can induce functional and anatomical changes along the auditory pathways. The inferior colliculus (IC) is a unique structure in the auditory system located between the primary auditory nuclei of the brainstem and the thala-mus. Damage to the IC inhibitory circuitry may affect central auditory processing and sound perception. Here, we review some of the striking electrophysiological changes in the IC that occur after noise exposure and ototoxic drug treatment. A common occurrence that emerges in the IC after peripheral damage is hyper-excitability of sound-evoked response. The hyperexcitability of the IC is likely related with reduced inhibi-tory response that requires normal peripheral inputs. Early age hearing loss can result in a long lasting in-creased susceptibility to audiogenic seizure which is related to hyperactivity in the IC evoked by loud sounds. Our studies suggest that hearing loss can cause increased IC neuron responsiveness which may be related to tinnitus, hyperacusis, and audiogenic seizure.

关键词： inferior colliculus noise exposure salicylate audiogenic seizure tinnitus hyperacusis

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FIRING PROPERTY OF inferior colliculus NEURONS AFFECTED BY FMR1 GENE MUTATION

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Journal of Otology 2014年第2期9卷 86-90页

作者： Brittany Mott SUN Wei Department of Communicative Disorders and Sciences State University of New York at Buffalo137 Cary Hall3435 Main StreetBuffaloNY 14214

Fragile X syndrome is the most common form of inherited mental retardation affecting up to 1 in 4000 individuals. The syn- drome is induced by a mutation in the FMR1 gene, causing a deficiency in its gene by-product FMRP. Impairment in the nor- mal functioning of FMRP leads to learning and memory deficits and heightened sensitivity to sensory stimuli, including sound （hyperacusis）. The molecular basis of fragile X syndrome is thoroughly understood; however, the neural mechanisms underly- ing hyperacusis have not yet been determined. As the inferior colliculus （IC） is the principal midbrain nucleus of the auditory pathway, the current study addresses the questions underlying the neural mechanism of hyperacusis within the IC of fragile X mice. Acute experiments were performed in which electrophysiological recordings of the IC in FMR1-KO and WT mice were measured. Results showed that Q-values for WT were significantly larger than that of FMR-1 KO mice, indicating that WT mice exhibit sharper tuning curves than FMR1-KO mice. We also found the ratio of the monotonic neurons in the KO mice was much higher than the WT mice. These results suggest that lack of FMRP in the auditory system affects the developmental maturation and function of structures within the auditory pathway, and in this case specifically the IC. The dysfunction ob- served within the auditory neural pathway and in particular the IC may be related to the increased susceptibility to sound as seen in individuals with fragile X syndrome. Our study may help on understanding the mechanisms of the fragile X syndrome and hyperacusis.

关键词： Fragile X syndrome inferior colliculus hyperacusis

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Neural modulation in inferior colliculus and central auditory plasticity

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Frontiers in Biology 2010年第2期5卷 123-127页

作者： Huixian MEI Qicai CHEN College of Life Sciences and Hubei Key Lab of Genetic Regulation and Integrative Biology Central China Normal UniversityWuhan 430079China School of Life Sciences Wuhan University of Science and Technology Zhongnan BranchWuhan 430223China

The neural modulation in central auditory system plays an important role in perception and processing of sound signal and auditory *** inferior colliculus(IC)is both a relay station in central auditory pathway and a sub-cortical auditory center doing the sound signal *** is also modulated by the descending projections from the cortex and auditory thalamus,medial geniculate body,and these neural modulations not only can affect ongoing sound signal processing but can also induce plastic changes in IC.

关键词： neural modulation auditory plasticity inferior colliculus

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Effects of salicylate on transient outward and delayed rectifier potassium channels in rat inferior colliculus neurons

Effects of salicylate on transient outward and delayed recti...

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中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会

作者： Liu Yan-xing , Li Xue-pei Department of Otorhinolaryngology, Peking University Third Hospital, Beijing 100083, China

＜正＞The effects of salicylate （a tinnitus inducer） were studied on the transient outward potassium current （IK（A）） and the delayed rectifier potassium current （IK（DR）） in acutely dissociated rat inferior olliculus neurons by the whole-cell voltage-clamp method. Salicylate’s inhibition of the amplitude of IK（A） and IK（DR） was concentration-dependent. The IC50 values for the blocking action of salicylate on IK（A） and IK（DR） were 2.27 and 0.80 mmol/L, respectively. At a concentration of 1 mmol/L, salicylate significantly shifted the activation and inacti（?）ation curves of IK（DR） negatively by approximately 11 and 24mV, respectively, but did not shift the IK（A） curves. In conclusion, salicylate inhibits both IK（A） and IK（DR） in rat inferior colliculus neurons but only significantly affects the activation and inactivation kinetics of IK（DR）. Depression of IK（DR） by salicylate may play an important role in salicylate-induced tinnitus.

关键词： salicylate tinnitus inferior colliculus potassium current patch clamp

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Recovery Cycle of Single-on and Double-on Neurons in inferior colliculus of CF-FM Bat

Recovery Cycle of Single-on and Double-on Neurons in Inferio...

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“基因、进化与生理功能多样性”海内外学术研讨会暨中国生理学会第七届比较生理学学术会议

作者：唐佳 Philip H.S.Jen College of Life Sciences and Hubei Key Lab of Genetic Regulation & Integrative Biology Central China normal university Division of Biological Sciences University of Missouri-ColumbiaMO 65211USA

The bats scan the surrounding and hunt insects by emitting continuous sequences of echolocation *** is very important for echolocation bats that the recovery cycle of central auditory neurons can determine the responses of neurons to second sound stimulation. For constant frequency-frequency modulation (CF-FM) bats,there is some overlap between emitted sound signal and echo under anyhow low or high pulse repetition rate condition. But the CF-FM bats still can extract information from echo and discriminate the target from the background much better. Therefore,it is a very interesting question that how CF-FM bats can be against the overlap between emitted sound signal and echo.

关键词： CF-FM bat inferior colliculus Recovery cycle

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Temporal representation in the inferior colliculus of barbital-anesthetized albino mouse．——Unit response to tone bursts sequences

Temporal representation in the inferior colliculus of barbit...

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第十次中国生物物理学术大会

作者： Nikolay G.Bibikov N. N. Andreyev Acoustical Institute of Federal Science Center of Russia 117036 Schveenik st.4Moscow Russia

＜正＞We recorded the extracellular activities from 402 single units located in the inferior colliculus （IC） of barbiturate-anesthetized albino mice （Mus musculus Km）. The stimuli were pure tone bursts at characte... 详细信息

关键词： inferior colliculus auditory units duration tuning presentation rate bicuculine mouse.

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