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Preventive and therapeutic effect of N-Acetyl-L-cysteine on infection-associated preterm labor in mice

Asian Pacific Journal of Tropical Medicine 2016年第2期9卷 195-198页

作者： Ling Jiang Qian Yan Rong-Hui Liu Lu Zhang Yantaishan Hospital Affiliated to Taishan Medical University

Objective:To study the preventive and therapeutic effect of N-Acetyl-L-cysteine on infectionassociated preterm labor in mice.Methods:A total of 66 C57BL/6 inbred strain pregnant mice were selected and randomly divided into groups A,B and C,with 22 cases in each group.Group A,B and C were regarded as model group,prevention group and treatment group,respectively.The model of infection-associated preterm labor was built by intraperitoneal injection of Escherichia coli.Ten mice of each group were taken and observed the preterm birth rates and live birth rates,respectively.Three mice of each group were killed at 3 h,6 h,12 h and 24 h after building the model.Their uterus tissues were collected and the expressions of the AP-1 and MCP-1 in those tissues were assayed with immunohistochemical method and the expressions of NF-κ Bp65 and TNF- protein in the placenta tissues of those mice were also detected with immunohistochemical method.Results:The preterm birth rates of mice in groups B and C were significantly lower than that in group A,while their live birth rates were distinctly higher than that in group A(P0.05).Conclusions:N-Acetyl-L-cysteine can lower the incidence rate of infection-associated preterm labor by prohibiting the activation of the protein AP-1/MCP-1and decreasing the expression of NF- κ Bp65 and TNF- in the pregnant tissues of premature mice to reduce the inflammatory reactions.

关键词： N-Acetyl-L-cysteine infection-associated preterm labor AP-1 MCP-1 NF-κ Bp65 TNF-α

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Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma

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World Journal of Gastroenterology 2013年第47期19卷 8831-8849页

作者： María L Bacigalupo Malena Manzi Gabriel A Rabinovich María F Troncoso Institute of Biological Chemistry and Biophysics "Prof. Alejandro C. Paladini" (UBA-CONICET) Department of Biological ChemistrySchool of Pharmacy and BiochemistryUniversity of Buenos AiresC1113AADBuenos AiresArgentina Institute of Biology and Experimental Medicine (CONICET) Department of Biological ChemistrySchool of Exact and Natural SciencesUniversity of Buenos AiresC1113AAD Buenos AiresArgentina

Hepatocellular carcinoma(HCC)represents a global health problem.infections with hepatitis B or C virus,non-alcoholic steatohepatitis disease,alcohol abuse,or dietary exposure to aflatoxin are the major risk factors to the development of this tumor.Regardless of the carcinogenic insult,HCC usually develops in a context of cirrhosis due to chronic inflammation and advanced fibrosis.Galectins are a family of evolutionarily-conserved proteins defined by at least one carbohydrate recognition domain with affinity forβ-galactosides and conserved sequence motifs.Here,we summarize the current literature implicating galectins in the pathogenesis of HCC.Expression of"proto-type"galectin-1,"chimera-type"galectin-3 and"tandem repeat-type"galectin-4 is up-regulated in HCC cells compared to their normal counterparts.On the other hand,the"tandemrepeat-type"lectins galectin-8 and galectin-9 are downregulated in tumor hepatocytes.The abnormal expression of these galectins correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,postoperative recurrence and poor prognosis.Moreover,these galectins have important roles in other pathological conditions of the liver,where chronic inflammation and/or fibrosis take place.Galectin-based therapies have been proposed to attenuate liver pathologies.Further functional studies are required to delineate the precise molecular mechanisms through which galectins contribute to HCC.

关键词： Galectins Hepatocellular carcinoma Inflammation-associated liver injury Hepatitis B or C virus infection-associated hepatocellular carcinoma Fibrosis-related liver pathologies

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