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Gastroesophageal manometry and 24-hour double pH monitoring in neonates with birth asphyxia

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World Journal of Gastroenterology 2001年第5期7卷 695-697页

作者： Mei Sun~1 Wei-Lin Wang~2 Wei Wang~2 De-Liang Wen~1 Hui Zhang~1 Yu-Kun Han~1 1 Pediatric Department,2 Pediatric Surgery Department,Second Clinical College,China Medical University,Shenyang 110003,China Pediatric Department Second Clinical College China Medical University Shenyang 110003 China. meis@***

INTRODUCTIONBirth asphyxia may lead to disturbances of gastroenteric motility of newborn infants[1.2] . The change of gut pressure and reflux are the major manifestations of the motor disturbance [3-9] . To evaluate the effects of perinatal asphyxia on the gastroenteric motility, gastric and esophageal pressure and double pH were measured in a group of asphyxiated newborns. And. their pathophysiological and anatomical effects on gastroenteric function were discussed.

关键词： Asphyxia Neonatorum Esophagus Gastroesophageal Reflux Humans Hydrogen-Ion Concentration infant, newborn Manometry Monitoring, Physiologic Research Support, Non-U.S. Gov't Stomach

Gastric malignancies in Northern Jordan with special emphasis on descriptive epidemiology

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World Journal of Gastroenterology 2004年第15期10卷 2174-2178页

作者： Kamal E.Bani-Hani Rami J.Yaghan Hussein A.Heis Nawaf J.Shatnawi Ismail I.Matalka Amjad M.Bani-Hani Kamal A.Gharaibeh Department of Surgery Princess Basma Teaching Hospital Faculty of MedicineJordan University of Science & TechnologyIrbid-Jordan Department of Pathology Princess Basma Teaching HospitalFaculty of MedicineJordan University of Science & TechnologyIrbid-Jordan Department of Surgery Princess Basma Teaching Hospital Faculty of MedicineJordan University of Science & TechnologyIrbid- Jordan

AIM:To study the epidemiology of gastric malignancies in Jordan as a model for Middle East countries where such data is scarce. METHODS:Pertinent epidemiological and clinicopathological data for 201 patients with gastric malignancy in north of Jordan between 1991 and 2001 were analyzed. RESULTS:Male:female ratio was 1.8:*** mean age was 61.2 years,and 8.5% of the patients were younger than 40 years of *** overall age-adjusted incidence was 5.82/100 000 population/*** age specific incidence for males raised from 1.48 in those aged 30-39 years to 72.4 in those aged 70-79 ***, gastric lymphomas,malignant stromal tumors,and carcinoids were found in 87.5%,8%,2.5%,and 2% *** was an average of 10.1-month delay between the initial symptoms and the *** 82 patients underwent“curative”*** adenocarcinoma groups,Lauren intestinal type was the commonest(72.2%)and the distal third was the most common localization(48.9%).The mean follow up for patients with gastric adenocarcinoma was 25.1 mo(range 1-132mo).The 5-year survival rates for stages Ⅰ(n=15), Ⅱ(n=41),Ⅲ(n=59),and Ⅳ(n=53) were 67.3%,41.3%, 5.7%,and 0% respectively(P=0.0001).The overall 5 year survival was 21.1%. CONCLUSION:Despite low inddence,some epidemiological features of gastric cancer in Jordan mimic those of high- risk *** are detected and treated after a relatively long *** justification in favor of a possible gastric cancer screening effort in Jordan is supported by our study;rather,the need of an earlier diagnosis and subsequent better care.

关键词： Adolescent Adult Age Distribution Aged Aged, 80 and over Child Child, Preschool Female Gastrectomy numerical data Humans Incidence infant infant, newborn Jordan Male Middle Aged Sex Distribution Stomach Neoplasms Survival Analysis

Investigation of regurgitation and other symptoms of gastroesophageal reflux in Indonesian infants

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World Journal of Gastroenterology 2004年第12期10卷 1795-1797页

作者： Badriul Hegar Aswitha Boediarso Agus Firmansyah Yvan Vandenplas Department of Pediatrics Cipto Mangunkusumo HospitalUniversity of IndonesiaJakartaIndonesia Department of Pediatrics Academisch Ziekenhuis Vrije UniversiteitBrusselBrusselsBelgium

AIM:To evaluate the incidence of regurgitation and other symptoms of gastroesophageal reflux in Indonesian infants. METHODS:In a cross-sectional study at the University Outpatient Clinic for vaccination in Jakarta,138 mothers of healthy infants less than 12-mo old were prospectively asked to report the frequency of regurgitation. RESULTS:Whatever the age was,some infants did not regurgitate(from 10% during the first month of life to 67% in 1-year-old infants).Regurgitation of at least once a day was reported in 77% of infants younger than 3 *** regurgitation decreased to 12% in the 9-12 mo old group. Reported peak prevalence was 81%(26/32)during the first month of *** decreased sharply between the 4-6 and 7-9 mo old groups(from 44% to 9%).The longer the regurgitation persisted,the more frequently the mother perceived regurgitation as a *** and frequency of regurgitation,back arching,irritability,crying and refusal of feeding were the symptoms causing maternal *** longer the regurgitation persisted,the more frequently the mothers viewed it as a health problem. CONCLUSION:Regurgitation occurs frequently in Indonesian infants,and is a frequent cause of concern to mothers.

关键词： Adult Cross-Sectional Studies Female Gastroesophageal Reflux Humans Indonesia infant infant, newborn Irritable Mood Male Mothers Prevalence Prospective Studies

Transphyseal separation of the distal humerus in newborns

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Chinese Journal of Traumatology 2017年第3期20卷 183-186页

作者： Cosimo Gigante Sunil Gurpur Kini Carlo Origo Andrea Volpin Unit of Paediatric Orthopaedics Azienda Ospedaliera di Pndova. 35128. Padova. Italy Department of Orthopaedics Manipal Hospitals Bangalore India Department of Paediatric Orthopaedics Hospital C Arrigo Alessandria Italy

Obstetric traumatic separation of the distal humeral epiphysis is a very uncommon injury, which pre- sents a diagnostic challenge. These case serials reviewed the functional outcomes of 5 patients who had sustained a fracture-separation of the distal humeral epiphysis at birth. The diagnosis was made at a mean time of 40.8 h after delivery. All the patients were treated with gentle close manipulation, reduction under fluoroscopy and above-elbow cast application. After discharge, the patients were fol- lowed up for a mean of 30 months. Clinico-radiological results were excellent in four patients. One case necessitated closed reduction and percutaneous K-wire fixation at one week follow-up due to failed reduction. Cubitusvarus deformity was the only complication noted in I case. Good functional outcome can be expected in newborns with fracture-separation of the distal humeral epiphysis wherein the physis is anatomically reduced.

关键词： infant, newborn Humerus Separation of epiphysis

Critical Review of Massage Therapy Employed for newborns

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Journal of Acupuncture and Tuina Science 2009年第6期7卷 379-384页

作者：黄琳 Nursing College of Chengdu University of Traditional Chinese Medicine

Objective： To evaluate the outcomes of current studies regarding the beneficial effects of infant massage therapy. Method： Firstly, some common knowledge related to massage is provided. Subsequently, research-based evidence on massage effects in neonatal unit has been examined, particularly on premature babies and newborns with jaundice. Result and Conclusion： the practice of massage therapy promotes the development of preterm babies and the treatment of neonates with jaundice generally safe, however the methodology employed in reviewed studies is of certain limitations, such as a lack of RCT with large sample size, inadequate follow-up period.

关键词： Tuina Massage infant, newborn

Effect of Combined Acupuncture and Rehabilitation on High-risk infants with Perinatal Brain Injuries

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Journal of Acupuncture and Tuina Science 2010年第4期8卷 222-225页

作者：曹文胜胡敏覃丽梅 Zhangjiajie People's Hospital. Hunan 427000 R R. China

Objective： To investigate the effect of combined acupuncture and rehabilitation on intelligence and motor development of high risk infants with perinatal brain injuries. Methods： Ninety-seven survived cases in the neonatal intensive care unit （NICU） were allocated into a treatment group of 53 cases and a control group of 44 cases following the consent of the parents. Cases in the treatment group were treated by combined acupuncture and rehabilitation; whereas cases in the control group were treated by conventional child care methods. Systemic follow-up has been made for 2 years. Then the infants＇ intelligence was evaluated respectively in the 6th, 12th and 34th months. Results： Compared with the control group, the mental development indexes （MDI） and physical development indexes （PDI） in the treatment group were increased by 14.96 and 9.82 respectively. There was a significant difference （χ2=8.1659, P〈0.01 ） in the abnormal intelligence rates between the treatment group （15.1%） and the control group （40.9%,）. Conclusion： Combined acupuncture and rehabilitation can effectively improve the mental and physical development of high-risk infants with perinatal brain injuries. Additionally, this therapy can decrease the disability rates and increase the infants＇ quality of life.

关键词： Brain Injuries Acupuncture Therapy Rehabilitation Cerebral Palsy infant, newborn

Impact of a nationwide training program for neonatal resuscitation in China

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Chinese Medical Journal 2012年第8期125卷 1448-1456页

作者： XU Tao WANG Hui-shan YE Hong-mao YU Ren-jie HUANG Xing-hua WANG Dan-hua Wang Li-xin FENG Qi GONG Li-min MA Yi William Keenan Susan Niermeyer National Center for Women and Children＇s Health Chinese Center for Disease Control and Prevention Beijing 100089 China Department of Pediatrics Peking University Third Hospital Beijing 100191 China Department of Pediatrics Tsinghua University First Hospital Beijing 100016 China Department of Obstetrics Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University Beijing 100026 China Department of Pediatrics Peking Union Medical College Hospital Beijing 100730 China Department of Pediatrics Peking University First Hospital Beijing 100034 China Cardinal Glennon Children＇s Hospital and St. Louis University School of Medicine St. Louis Missouri USA Section of Neonatology Children＇s Hospital and University of Colorado Denver School of Medicine Colorado School of Public Health13121 E. 17th Avenue Mail Stop 8402 Aurora Colorado 80045 USA

Background Seventeen million births occur in China each year. Neonatal mortality is the leading cause of under 5-year-old child deaths, and intrapartum-related injury accounts for much of mental retardation in young children. The Chinese Ministry of Health sought to improve infant and child survival through a nationwide initiative to have at least one person trained in neonatal resuscitation at every birth. The aim of the current study was to evaluate the impact of China Neonatal Resuscitation Program （NRP） on policy and infrastructure changes and its effectiveness in decreasing the incidence of mortality among newborn infants. Methods The Chinese NRP incorporated policy change, professional education, and creation of a sustainable health system infrastructure for resuscitation. Multidisciplinary teams from all 31 provinces and municipal states disseminated NRP in a train-the-trainer cascade. The intervention targeted 20 provinces with high neonatal mortality and programs to reduce maternal mortality. Program evaluation data came from 322 representative hospitals in those provinces. Results Changes in policy permitted midwives to initiate resuscitation and required resuscitation training for licensure. From 2004 through 2009 more than 110 659 professionals received NRP training in the 20 target provinces, with 94% of delivery facilities and 99% of counties reached. Intrapartum-related deaths in the delivery room decreased from 7.5 to 3.4 per 10 000 from 2003 to 2008, and the incidence of Apgar 〈7 at 1 minute decreased from 6.3% to 2.9%. Conclusions The Chinese NRP achieved policy changes promoting resuscitation, trained large numbers of professionals, and contributed to reduction in delivery room mortality. Improved adherence to the resuscitation algorithm, extension of training to the township level, and coverage of births now occurring outside health facilities can further increase the number of lives saved.

关键词： resuscitation infant, newborn asphyxia neonatorum neonatal mortality in-service training, China

Mechanism of peripheral blood mononuclear cell invasion by HBV on artificial immunization in newborns

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Chinese Medical Journal 2002年第9期115卷 1380-1382,153-154页

作者：岳亚飞孟金来张树林西安交通大学第一医院妇产科西安710061

OBJECTIVE: To study the effect and mechanism of the peripheral blood mononuclear cell (PBMC) invasion by HBV on artificial immunization in newborns. METHODS: Fifty-two newborns of HBsAg positive mothers were immunized with HBIG (hepatitis B immunoglobulin) and HBVac (hepatitis B vaccine) and were followed up for 7 months. The newborns' HBV-DNA in serum and in the PBMCs was detected with nested-PCR; anti-HBs was tested with solid phase radioimmunoassay (SP-RIA). PBMCs isolated from newborn peripheral blood were incubated in the presence of PHA or purified HBsAg. Interleukin-2 (IL-2) level in culture supernatants of activated cells was detected by ELISA. RESULTS: The failure rate of immunization was higher in infants with positive HBV-DNA in PBMCs than those with negative HBV-DNA (P

关键词： DNA, Viral Hepatitis B Surface Antigens Hepatitis B Vaccines Hepatitis B virus Humans Immunization Immunoglobulins infant, newborn Interleukin-2 Leukocytes, Mononuclear

Expression and effect of basic fibroblast growth factor on human cataract lens epithelial cells

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Chinese Medical Journal 2002年第2期115卷 268-271,156页

作者：申屠形超姚克孙朝晖徐雯吴仁毅浙江大学附属第二医院眼科中心浙江310009

OBJECTIVE: To detect the expression of basic fibroblast growth factor (bFGF) in human ocular tissues, and to assess the effect of bFGF on the proliferation of human cataract lens epithelial cells (LECs) and its correlation with age. METHODS: Enucleated eyes were subjected to immunostaining for bFGF protein. Human cataract LECs were cultured in vitro, and treated with bFGF for 48 hr. Proliferation was estimated by the positive area ratio of proliferating cell nuclear antigen (PCNA) in immunohistochemistry. RESULTS: bFGF protein was found in various human ocular tissues. bFGF stimulated human cataract LEC proliferation, and there was an age-related decrease in responsiveness of human cataract LECs to bFGF (P

关键词： Adolescent Adult Age Factors Cataract Child Child, Preschool Epithelial Cells Fibroblast Growth Factor 2 Humans Immunohistochemistry infant infant, newborn Lens, Crystalline Middle Aged Proliferating Cell Nuclear Antigen Research Support, Non-U.S. Gov't