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Resolution of acute gastroenteritis symptoms in children and adults treated with a novel polyphenol-based prebiotic

World Journal of Gastroenterology 2014年第34期20卷 12301-12307页

作者： Telma Noguera Robert Wotring Chris R Melville Kara Hargraves Jochen Kumm John M Morton Instituto Centroamericano de Investigación Clínica Managua 050-008-4Nicaragua Greenteaspoon Inc StanfordCA 94305United States Department of Biology Stanford UniversityStanfordCA 94305United States Bariatric and Minimally Invasive Surgery Stanford School of MedicineStanfordCA 94305United States

AIM:To test efficacy and durability of a polyphenolbased prebiotic treatment for acute gastroenteritis in a300 patient double-blinded clinical study.METHODS:A two-arm randomized,double-blinded,placebo-controlled clinical study was conducted at two public health centers in Managua,Nicaragua.Potential subjects who qualified based on inclusion and exclusion criteria were randomly assigned to one of two treatment arms.Two thirds of the subjects(n=200)received a single titrated 0.5-2 ounce liquid dose of a novel polyphenol-based prebiotic(AlivaTM)diluted with 2 to eight ounces of oral rehydration solution(ORS).One third of the subjects(n=100)were randomized to receive two liquid ounces of a taste and color-matched placebo diluted in eight ounces of ORS.The outcome variables measured included stool consistency,stomach discomfort,gas and bloating,and heartburn/indigestion.The study subjects ranked their stool consistency and the severity of their subjective symptoms at specified intervals from immediately prior to treatment,to five days post treatment.All subjects recorded their symptoms in a study diary.The study subjects also recorded the time and consistencies of all stools in their study diary.Stool consistency was compared to the picture and descriptions on the Bristol Stool Chart,and any stool rated greater than Type4 was considered unformed.The clinical study team reviewed the study diaries with subjects during daily follow-up calls and close-out visits,and recorded the data in case report forms.RESULTS:After receiving a single dose,Aliva treated subjects reported shorter median time to their last unformed stool(1 h 50 min)than placebo treated subjects(67 h 50 min.),a statistically significant difference[95%CI:-3178-(-2018),P=0.000].Aliva treated subjects also reported shorter median their time to last unformed stool(TTLUS)(1hrs 50 min)than placebo treated subjects(67 h 50 min),which was also a statistically significant difference(P=0.000).The percentage of subjects recording TTLUS was greater for those who recei

关键词： Prebiotic Gastroenteritis Diarrhea Rotavirus infan

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Successful endoscopic submucosal dissection of a giant polyp in a 21-month-old female

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World Journal of Gastroenterology 2014年第1期20卷 323-325页

作者： Eun-Young Jung Soon-Ok Choi Kwang Bum Cho Eun Soo Kim Kyung Sik Park Jin-Bok Hwang Department of Pediatric Surgery Division of Gastroenterology and HepatologyKeimyung University School of MedicineDaegu 700-712South Korea Department of Internal Medicine Division of Gastroenterology and HepatologyKeimyung University School of MedicineDaegu 700-712South Korea Division of Gastroenterology and Hepatology Department of PediatricsKeimyung University School of MedicineDaegu 700-712South Korea

Endoscopic submucosal dissection(ESD)is now recognized as the preferred treatment modality for gastrointestinal epithelial lesions.A 21-month-old female was admitted with a giant hyperplastic polyp causing a gastric outlet obstruction.Successful ESD was performed with caution.The post-procedural course was uneventful without a bleeding episode.Although further study of the feasibility of ESD in early children is necessary,ESD could be applied to avoid laparotomy even in young children.

关键词： Obstruction Endoscopic submucosal dissection infan

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