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Enlightenment about using TCM constitutions for individualized medicine and construction of Chinese-style precision medicine:research progress with TCM constitutions

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Science China(Life Sciences) 2021年第12期64卷 2092-2099页

作者： Lingru Li Zhenyu Wang Ji Wang Yanfei Zheng Yingshuai Li Qi Wang Center for Studies in Constitution Research of Traditional Chinese medicine Beijing University of Chinese MedicineBeijing 100029China

TCM constitution is a new branch of *** provides enlightenment on individualized medicine,including the development of new models of individualized research based on nine constitutions,the acquisition of comprehensive health information for individuals,and establishment of a consistent individualized diagnosis and treatment ***,we propose a Chinesestyle“precision medicine”based on individualization using the TCM constitutions.

关键词： TCM constitution constitutional classification individualized medicine precision medicine

Incorporating Pattern Identification of Chinese medicine into Precision medicine:An Integrative Model for individualized medicine

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Chinese Journal of Integrative medicine 2015年第11期21卷 807-810页

作者：李金根徐浩 Graduate School Beijing University of Chinese Medicine Cardiovascular Diseases Center Xiyuan HospitalChina Academy of Chinese Medical Sciences

On 20 January, 2015, U.S. President Obama announced an ambitious plan called ＂Precision medicine （PM） Initiative＂, aiming to deliver genetics- based medical treatments. PM has shown a promising prospect by tailoring disease treatments and preventions to individuals. However, a predominantly genetics-based method restricts its benefit and applicability in most chronic and complex diseases. Pattern identification （PI） is one of the representative characteristics of Chinese medicine implying the concept of holism and individualized treatment. It is another classification method taking environmental, psychosocial and other individual factors into account. Integrating PI with disease diagnosis of Western medicine will provide a strong complement to genetics-based PM, thus establish an integrative model for individualized medicine. PI provides new perspectives for PM, not only in clinical practice, but also in new drug development and clinical trial design. It is for sure that the integrative approach will ultimately lead to a safer, more convenient and effective patient-centered healthcare and most patients will benefit in the era of PM.

关键词： precision medicine Chinese medicine pattern identification syndrome differentiation individualized medicine

Application of patient-derived tumor models in anticancer drug development and individualized medicine

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Life Research 2024年第1期7卷 3-9页

作者： Kai-Ling Chen Yu-Fei Deng Xiao-Ying Hou Yu-Chen Liu Wuhan Institute of Biomedical Sciences School of MedicineJianghan UniversityWuhan 430056China Cancer Institute School of MedicineJianghan UniversityWuhan 430056China

Malignant tumor is the second leading cause of death due to its high incidence, lack of effective treatment and poor prognosis. The evaluation of anticancer drugs used to based on NCI-60 cell line models, but the limited heterogeneity and the divorce from clinical practice of models lead to extremely low success rate of novel anticancer drugs during clinical trials (less than 10%). In recent years, because of the high heterogeneity and human derived tumor matrix, patient-derived tumor models have been gradually applied to the preclinical evaluation of various antitumor drugs, which shows certain advantages in predicting the clinical efficacy of antitumor drugs. Optimize the drug combination through patient-derived tumor models to achieve individualized medicine has gradually become an indispensable strategy in clinical cancer therapy. The current review summarized the development of patient-derived tumor models, characterized the application, advantages and challenges of them in preclinical antitumor drug evaluation and clinical precise medicine, which will provide a scientific basis and novel insights for further basic research, drug development and clinical application.

关键词： patient-derived xenograft(PDX) patient-derived organoid(PDO) patient-derived cell(PDC) individualized medicine

Pathological images for personal medicine in Hepatocellular carcinoma:Cross-talk of gene sequencing and pathological images

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Oncology Research 2022年第5期30卷 243-258页

作者： LI YANG KUN DENG ZHIQIANG MOU PINGFU XIONG JIAN WEN JING LI Department of General Surgery(Hepatobiliary Surgery) The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Academician(Expert)Workstation of Sichuan Province Luzhou646000China Department of General Surgery(Gastrointestinal Surgery) The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China

Background:Considering the great heterogeneity of Hepatocellular carcinoma(HCC),more accurate prognostic models are urgently *** paper combined the advantages of genomics and pathomics to construct a prognostic ***:First,we collected data from hepatocellular carcinoma patients with complete mRNA expression proﬁles and clinical annotations from the TCGA ***,based on immune-related genes,we used random forest plots to screen prognosis-related genes and build prognostic *** was used to identify biological pathways,evaluate the tumor microenvironment,and perform drug susceptibility ***,we divided the patients into different subgroups according to the gene model *** models were constructed by obtaining HE-stained sections from TCGA in corresponding subgroups of ***:In this study,we constructed a stable prognostic model that could predict overall survival in HCC *** signature consisted of six immune-related genes(BX537318.1,TMEM147,CSPG4P12,AC015908.3,CEBPZOS,and SRD5A3).We found increased levels of inﬁltration of immune cells in the tumor microenvironment in patients with low risk scores,indicating signiﬁcant antitumor immunity and corresponding to better clinical *** then screened nine drugs that were more sensitive in the low-risk group than in the high-risk ***,we addressed the complex cellular changes and phenotypic heterogeneity in the HCC microenvironment by combining genomics and pathomics analysis ***:Our study showed that the prognostic evaluation model of HCC based on the immune signaling pathway is feasible and provided a reference value for potential immunotherapy for HCC.

关键词： Hepatocellular carcinoma tumor environment individualized medicine predictive model pathological model

Pharmacogenetics research on chemotherapy resistance in colorectal cancer over the last 20 years

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World Journal of Gastroenterology 2014年第29期20卷 9775-9827页

作者： Mariusz Panczyk Laboratory of Molecular Diagnostics and Pharmacogenomics Department of Pharmaceutical BiochemistryMedical University of Lodz Division of Teaching and Outcomes of Education Faculty of Health ScienceMedical University of Warsaw

During the past two decades the first sequencing of the human genome was performed showing its high degree of inter-individual differentiation,as a result of large international research projects(Human Genome Project,the 1000 Genomes Project International HapMap Project,and Programs for Genomic Applications NHLBI-PGA).This period was also a time of intensive development of molecular biology techniques and enormous knowledge growth in the biology of *** clinical use in the treatment of patients with colorectal cancer(CRC),in addition to fluoropyrimidines,another two new cytostatic drugs were allowed:irinotecan and *** research into new treatment regimens and a new generation of drugs used in targeted therapy has also been *** last 20years was a time of numerous in vitro and in vivo studies on the molecular basis of drug *** of the most important factors limiting the effectiveness of chemotherapy is the primary and secondary resistance of cancer *** the genetic factors and mechanisms that contribute to the lack of or low sensitivity of tumour tissue to cytostatics is a key element in the currently developing trend of personalized *** hope to increase the percentage of positive treatment response in CRC patients due to practical applications of pharmacogenetics/*** the past 20 years the clinical usability of different predictive markers has been tested among which only a few have been confirmed to have high application *** review is a synthetic presentation of drug resistance in the context of CRC patient *** multifactorial nature and volume of the issues involved do not allow the author to present a comprehensive study on this subject in one review.

关键词： Pharmacogenetics Pharmacogenomics Drug resistance Colorectal cancer Chemoresistance individualized medicine

Practice guidance documents for the diagnosis and management of non-alcoholic fatty liver disease-recent updates and open questions

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 780-784页

作者： Volker M.Lauschke Dr Margarete Fischer-Bosch Institute of Clinical Pharmacology StuttgartGermany Department of Physiology and Pharmacology Karolinska InstitutetStockholmSweden University Tübingen TübingenGermany

Primarily driven by an increasingly sedentary lifestyle and hypercaloric nutritionally imbalanced diets,non-alcoholic fatty liver disease(NAFLD)has emerged as the most prevalent liver disease in the US and *** constitutes an umbrella term that includes a spectrum of disease from non-alcoholic fatty liver(NAFL)to non-alcoholic steatohepatitis(NASH),NASH fibrosis and NASH cirrhosis that are all characterized by≥5%of all hepatocytes being steatotic in patients with little alcohol intake and no apparent alternative causes.

关键词： Guidelines non-alcoholic steatohepatitis(NASH) fibrosis individualized medicine

Intensified Antiplatelet Treatment Reduces Major Cardiac Events in Patients with Clopidogrel Low Response： A Meta-analysis of Randomized Controlled Trials

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Chinese Medical Journal 2016年第8期129卷 984-991页

作者： Lei Xu Xiao-Wei Hu Shu-Hua Zhang Ji-Min Li Hui Zhu Ke Xu Jun Chen Chun-Jian Li Department of Cardiology First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210000 China Department of Cardiology Sir Yifu Hospital Affiliated to Nanjing Medical University Nanjing Jiangsu 211166 China Coronary Artery Disease Center First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210000 China Department of Cardiology People's Hospital of Maanshan City Maanshan Anhui 243000 China

Background：Clopidogrel low response （CLR） is an independent risk factor of adverse outcomes in patients undergoing percutaneous coronary intervention （PCI）,and intensified antiplatelet treatments （IAT） guided by platelet function assays might overcome laboratory ***,whether IAT improves clinical outcomes is ***：Relevant trials were identified in PubMed,the Cochrane Library,and the Chinese Medical Journal Network databases from their establishment to September 9,*** were screened using predefined inclusion *** meta-analysis and cumulative meta-analysis were performed using the Review Manager 5.0 and STATA 12.0 software ***：Thirteen randomized controlled trials involving 5111 patients with CLR were *** a follow-up period of 1-12 months,the incidences of cardiovascular （CV） death,nonfatal myocardial infarction （MI）,and stent thrombosis were significantly lower in the IAT arm than in the conventional antiplatelet treatment arm （relative risk [RR] =0.45,95% confidence interval [CI]：0.36-0.57,P 〈 0.000,01）,whereas bleeding was similar between the two arms （RR =1.05,95% CI：0.86-1.27,P =0.65）.Conclusions：IAT guided by platelet function assays reduces the risk of CV death,nonfatal MI,and stent thrombosis （ST） without an increased risk of bleeding in patients undergoing PCI and with CLR.

关键词： Coronary Artery Disease individualized medicine Platelet Aggregation Inhibitor Platelet Function Test

Surgical strategies for petroclival meningioma in 57 patients

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Chinese Medical Journal 2010年第20期123卷 2865-2873页

作者： LI Pei-liang MAO Ying ZHU Wei ZHAO Nai-qing ZHAO Yao CHEN Ling Department of Neurosurgery Huashan HospitalFudan UniversityShanghai 200040China Department of Biostatistics and Social medicine School of Public Health Fudan University Shanghai 200032 China

Background Resection of petroclival meningioma （PCM） is difficult for neurosurgeons and usually brings poor performance status. In this study, we evaluated the possible risk factors for unfavorable clinical outcomes of surgical treatment of PCM, and tried to explore the optimal surgical strategies for better postoperative quality of *** We recruited 57 patients （14 male, 43 female, mean age, 50.5 years） who underwent surgical resection of PCM in Huashan Hospital during 2002-2006. The primary outcomes including postoperative neurological deficits,modified Rankin scale （mRS） score and recurrence rate were evaluated, and all potential risk factors were assessed by the X2 test. Odds ratio and 95% confidence interval were calculated by univariate Logistic regression. The mean follow-up time was 34 *** Gross total resection was achieved in 58% of patients. One patient died during the perioperative period because of intracranial hemorrhage. Sixty-seven percent of patients experienced new postoperative neurological deficits and 26% had a higher mRS score at follow-up assessment. Postoperative complications were observed in 24 *** the follow-up period, radiographic recurrence occurred in 12.3% of patients at a mean follow-up of 42 *** radiosurgery was administered to 19 patients who had residual tumors or recurrence and no furtherprogression was found. Tumor adhesion, hypervascularity and engulfment of neurovascular structures were three risk factors for increased mRS score （P=0.0002; P=0.0051; P=0.0009）. Tumor adherence to adjacent structures clearly affected the extent of resection （P=0.0029）. The risk of postoperative cranial nerve deficits increased with tumor engulfment of neurovascular structures （P=0.0004）.Conclusions Intraoperatively defined tumor characteristics played a critical role in identifying postoperative functional status. An individual treatment strategy after careful preoperative evaluation could help impro

关键词： posterior fossa meningioma quality of life risk factors individualized medicine

Progress of radiation oncology： known and unknown

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Chinese Medical Journal 2014年第11期127卷 2173-2179页

作者： Liu Jing Yu Jinming Department of Radiation Oncology Shandong Cancer Hospital and Institute Shandong University Jinan Shandong 250117 China

Objective To elaborate known and unknown aspects of radiation *** sources Data cited in this review were obtained mainly from PubMed and Medline in English from 1999 to 2013,with keywords ＂individualized medicine＂,＂personalized medicine＂,＂radiation dose＂,＂radiation target＂,＂molecular targeted therapy＂,＂molecular imaging＂ and ＂functional imaging＂.Study selection Articles regarding radiation target delineation,radiation doses,new technology and equipment,combination of radiotherapy and molecular targeted therapy as well as other aspects were identified,retrieved and *** A larger radiation field and a higher radiation dose are not always *** equipment and technology are also not always better than conventional equipment and *** of radiotherapy combined with molecular targeted therapy needs more data to *** Personalized radiotherapy is the direction for the future.

关键词： individualized medicine radiotherapy positron-emission tomography targeted molecular therapy