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Differences in individual susceptibility affect the development of trigeminal neuralgia

Neural Regeneration Research 2013年第14期8卷 1337-1342页

作者： Yusuf Kurtulus Duransoy Mesut Mete Emrah Akay Mehmet Seluki Department of Neurosurgery Celal Bayar University School of Medicine Clinic of Neurosurgery Anamur State Hospital

Trigeminal neuralgia is a syndrome due to dysfunctional hyperactivity of the trigeminal nerve, and is characterized by a sudden, usually unilateral, recurrent lancinating pain arising from one or more divisions of the nerve. The most accepted pathogenetic mechanism for trigeminal neuralgia is compression of the nerve at its dorsal root entry zone or in its distal course. In this paper, we report four cases with trigeminal neuralgia due to an unknown mechanism after an intracranial intervention The onset of trigeminal neuralgia after surgical interventions that are unrelated to the trigeminal nerve suggests that in patients with greater individual susceptibility, nerve contact with the vascular structure due to postoperative pressure and changes in cerebrospinal fluid flow may cause the onset of pain.

关键词： neural regeneration peripheral nerve injury asymptomatic vascular compression of the cranialnerves cranial nerves dorsal root entry zone dorsal root exit zone etiology hyperactivedysfunction syndrome individual susceptibility risk factors trigeminal neuralgia neuroregeneration

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Association between physiological responses after exercise at low altitude and acute mountain sickness upon ascent is sex-dependent

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Military Medical Research 2021年第2期8卷 174-182页

作者： Yang Shen Yuan-Qi Yang Chuan Liu Jie Yang Ji-Hang Zhang Jun Jin Hu Tan Fang-Zheng-Yuan Yuan Jing-Bin Ke Chun-Yan He Lai-Ping Zhang Chen Zhang Jie Yu Lan Huang Institute of Cardiovascular Diseases of PLA the Second Affiliated HospitalArmy Medical UniversityChongqing 400037China Department of Cardiology the Second Affiliated HospitalArmy Medical UniversityChongqing 400037China

Background:Acute mountain sickness(AMS)is the mildest form of acute altitude illnesses,and consists of nonspecific symptoms when unacclimatized persons ascend to elevation of≥2500 *** factors of AMS include:the altitude,individual susceptibility,ascending rate and degree of *** the current study,we examined whether physiological response at low altitude could predict the development of ***:A total of 111 healthy adult healthy volunteers participated in this trial;and 99(67 men and 32 women)completed the entire study *** were asked to complete a 9-min exercise program using a mechanically braked bicycle ergometer at low altitude(500 m).Heart rate,blood pressure(BP)and pulse oxygen saturation(SpO2)were recorded prior to and during the last minute of *** ascent from 500 m to 4100 m was completed in 2 *** was defined as≥3 points in a 4-item Lake Louise Score,with at least one point from headache wat 6–8 h after the ***:Among the 99 assessable subjects,47(23 men and 24 women)developed AMS at 4100 *** comparison to the subjects without AMS,those who developed AMS had lower proportion of men(48.9%vs.84.6%,P<0.001),height(168.4±5.9 cm vs.171.3±6.1 cm,P=0.019),weight(62.0±10.0 kg vs.66.7±8.6 kg,P=0.014)and proportion of smokers(23.4%vs.51.9%,P=0.004).Multivariate regression analysis revealed the following independent risks for AMS:female sex(odds ratio(OR)=6.32,P<0.001),SpO2 change upon exercise at low altitude(OR=0.63,P=0.002)and systolic BP change after the ascent(OR=0.96,P=0.029).Women had larger reduction in SpO2 after the ascent,higher AMS percentage and absolute AMS *** reduction of SpO2 after exercise was associated with both AMS incidence(P=0.001)and AMS score(P<0.001)in men but not in ***:Larger SpO2 reduction after exercise at low altitude was an independent risk for AMS upon *** an association was more robust in men than in *** registration:Chinese Clinical

关键词： High altitude Exercise testing Sex differences Acute mountain sickness individual susceptibility

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-509C＞T polymorphism in the TGF-β1 gene promoter is not associated with susceptibility to and progression of colorectal cancer in Chinese

-509C＞T polymorphism in the TGF-β1 gene promoter is not as...

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全国临床免疫检验研讨会暨第六届全国临床免疫学术会议

作者： Peng Qi~(1△),Can-ping Ruan~(2△),Hao Wang~3,Fei-guo Zhou~4,Xin-yun Xu~2,Yun-peng Zhao~1, Xing Gu~1,Chun-fang Gao~(*1) 1.Department of Laboratory Medicine,Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200438,China 2.Department of General Surgery,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China 3.Department of Laboratory Medicine,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China 4.Department of Hepatic Surgery,Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200438,China.

Objective Colorectal cancer is one of the most common cancers in the world, accounting for nearly 10%of all incident cases of *** growth factor-β1 (TGF-β1) is a pleiotropic cytokine that has been implicated in the pathogenesis of colorectal *** most studied -509C>T polymorphism of TGF-β1 gene has been associated with various kinds of *** aim was to investigate the association between this genetic variant and the risk and/or progression of colorectal cancer. Method We conducted a case-control study of 150 colorectal cancer cases and 503 healthy *** was extracted from blood specimens,and -509C>T polymorphism in the TGF-β1 gene promoter was genotyped by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).In addition,colorectal cancer tissues(n=70) were obtained from the studied cases for measurement of TGF-β1 mRNA expression *** also assessed the plasma TGF-β1 levels of cases(n=88) and healthy subjects (n=120).Results In our study group,the high TGF-β1 producer genotypes,-509TT,was not associated with an increased risk of colorectal cancer compared with other genotypes, nor with the progression of colorectal ***,we observed that colorectal cancer patients especially those with a more aggressive disease behavior were more frequent with C *** Our results suggest that TGF-β1 -509C>T polymorphism was not associated with both an increased risk and progression of colorectal cancer.

关键词： Colorectal cancer transforming growth factor-β1 single-nucleotide polymorphism case-control study individual susceptibility

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Increased frequency of the CTLA-4 +49A>G polymorphism in Chinese patients with colorectal cancer compared to healthy controls

Increased frequency of the CTLA-4 +49A>G polymorphism in Chi...

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全国临床免疫检验研讨会暨第六届全国临床免疫学术会议

作者： Peng Qi~1,Can-ping Ruan~2,Tong-hai Dou~3,Hao Wang~4,Fei-guo Zhou~5,Xin-yun Xu~2,Xing Gu~1,Yun-peng Zhao~1,Chun-fang Gao~(*1) 5.Department of Laboratory Medicine,Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200438,China 6.Department of General Surgery,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China 7.Institute of Genetics,Fudan University,Shanghai 20043,China 8.Department of Laboratory Medicine,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China 9.Department of Hepatic Surgery,Eastern Hepatobiliary Hospital,Second Military Medical University,Shanghai 200438,China.

Objective Colorectal cancer is one of the most common malignancies in the world and a multipathway *** T-lymphocyte antigen-4(CTLA-4) is a potent immunoregulatory molecule that suppresses antitumor response by down-regulating T-cell *** most studied +49A>G polymorphism of CTLA-4 gene has been associated with various kinds of *** aim was to investigate the association between this genetic variant and the risk and progression of colorectal cancer in Chinese. Method We conducted a case-control study of 124 colorectal cancer cases and 407 healthy *** was extracted from blood specimens,and +49A>G polymorphism in the CTLA-4 gene was genotyped by polymerase chain reaction-ligation detection reaction(PCR-LDR).Results In our study group,the frequency of AG or GG or carrying at least one G allele at position +49 was significantly different in colorectal cancer patients and the control group,indicating that the risk of CRC was significantly higher among subjects with the AG or GG genotype or carrying at least one G allele at position +49 than among the subjects with the AA ***,we observed no association between CTLA-4 +49A>G polymorphism and the progression of CRC including tumor stage,tumor grade,status of lymph node and distant ***,the CTLA-4 +49A allele was in non-significantly higher numbers in CRC patients with distant *** Our results suggested that CTLA-4 +49A>G polymorphism was associated with an increased risk of colorectal cancer,but this polymorphism did not play an important role in Chinese patients with CRC.

关键词： Colorectal cancer cytotoxic T-lymphocyte antigen-4 single-nucleotide polymorphism case-control study individual susceptibility

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