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Early efficacy of individual regimens containing bedaquiline in patients with drug resistant tuberculosis

Asian Pacific Journal of Tropical Medicine 2023年第4期16卷 169-175页

作者： Oki Nugraha Putra Yulistiani Yulistiani Soedarsono Soedarsono Susi Subay Doctoral Program of Pharmacy Faculty of PharmacyAirlangga UniversitySurabayaIndonesia Program Study of Pharmacy Faculty of MedicineHang Tuah UniversitySurabayaIndonesia Faculty of Pharmacy Airlangga UniversitySurabayaIndonesia Faculty of Medicine Hang Tuah UniversitySurabayaIndonesia Department of Pulmonology and Respiratory Medicine Dr.Soetomo HospitalSurabayaIndonesia

Objective:To evaluate early efficacy of sputum conversion within 6 months of individual regimens containing bedaquiline in patients with drug resistant ***:We conducted a retrospective study among patients with drug resistant tuberculosis who were receiving individual regimens containing *** primary outcome was sputum conversion of both smear and culture within 6 months of *** used medical records of drug resistant tuberculosis patients from January 2020 to December *** study was conducted at *** Hospital,Indonesia from August to October ***:In this study,44 eligible drug resistant tuberculosis patients were initiated on regimens containing *** were 52.3%males and the median age was 45.5 *** rates of previous treatment(70.5%)and lung cavity(36.4%)were *** most common companion drugs included clofazimine,cycloserine,levofloxacin,and *** smear and culture conversion was seen in 79.4%and 82.1%at the 2nd month,*** than 97%patients had smear and culture conversion at the end of 6 ***:Among drug resistant tuberculosis patients,individual regimens containing bedaquiline were associated with high rates of smear and culture conversion at the end of 6 *** efficacy of regimens containing bedaquiline can be used to predict cure rate at the end of treatment.

关键词： Bedaquiline individual regimen Drug resistant tuberculosis Efficacy

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