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indicators of sorafenib efficacy in patients with advanced hepatocellular carcinoma

World Journal of Gastroenterology 2014年第35期20卷 12581-12587页

作者： Masayoshi Yada Akihide Masumoto Kenta Motomura Hirotaka Tajiri Yusuke Morita Hideo Suzuki Takeshi Senju Toshimasa Koyanagi Department of Hepatology Iizuka Hospital

AIM:To determine significant indicators for the efficacy of sorafenib in patients with advanced hepatocellular carcinoma(HCC).METHODS:A total of 46 patients with Barcelona Clinic Liver Cancer stage C who received sorafenib for more than 30 d at the Iizuka Hospital from June 2009 to December 2012 were enrolled in this *** and univariate analyses were performed to evaluate the associations of hepatic function according to Child-Pugh grade,location and size of the largest tumor and adverse events of sorafenib treatment,such as hand-foot syndrome(HFS),hypertension,diarrhea,and alopecia,with the efficacy of treatment,as measured by overall survival(OS)and time to progression(TTP).RESULTS:Patients included 39 men and 7 women whose ages ranged from 48 to 85 years(70.6±9.6years).HCC was classified according to etiology as follows:hepatitis C virus(n=26),hepatitis B virus(n=9),and other(n=11).Liver function in patients was categorized as Child-Pugh grade A(n=30)or B(n=16).Tumors were categorized by size[5 cm(n=13)]and the location of the largest tumor was used to categorize patients with intrahepatic(n=28)or extrahepatic(n=18)***,hypertension,diarrhea,and alopecia were present in22(47.8%),19(41.3%),15(32.6%)and 7 patients(15.2%),*** median OS of all patients was 373 d and the median TTP was 112 *** etiology of HCC did not correlate with the median OS and *** median OS of patients with tumors<5 cm was significantly longer than those with larger tumors(496 vs 245 d;HR=0.19,95%CI:0.07-0.48;P<0.01).According to the results of a multivariate analysis,the size of the largest tumor affected OS(HR=0.22,95%CI:0.08-0.59;P<0.01).The median TTP was significantly longer in patients with extrahepatic compared to intrahepatic major HCC(224 vs 98 d;HR=0.32;95%CI:0.14-0.67;P<0.01).The median TTP of patients with HFS was significantly longer than those without it(195 d vs 83 d;HR=0.41,95%CI:0.20-0.82;P<0.05),and the median TTP was significan

关键词： Hand-foot syndrome Hepatocellular car-cinoma indic

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Report on the Prosperity Index of the Petrochemical Industry

引用

China Chemical Reporter 2009年第25期20卷 5-6页

A report released jointly by the ResearchCenter for the Chinese Economic and Indus-trial Prosperity Index, the Economic Daily,and China Economic Monitoring Center ofthe National Bureau of Statistics of China,claims that in the second quarter of 2009 (Q22009), there were positive changes in the op-eration indicators of the Chinese petrochemi-cal industry. Compared to the first quarter of2009 (Q 1 2009), investment and total profitsgrew substantially in this industry in Q2 *** the same time, manufacturing enterprisesactively reduced their inventories and con-trolled their production, leading to a reboundof the business climate index in Q2 *** report says that in Q2 2009, the pros-perity index of the Chinese petroleum sectorwas 97.87 (with the 2006 level as

关键词： quarter Petroleum jointly petroleum released indic

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