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Omicron variants breakthrough infection elicited higher specific memory immunity than third dose booster in healthy vaccinees

引用

Virologica Sinica 2023年第2期38卷 233-243页

作者： Pei Yu Zijian Liu Zhuoqi Zhu Jiaqing Yang Min Deng Mingxiao Chen Changchun Lai Weiya Kong Shilong Xiong Li Wan Weikang Mai Lu Chen Yu Lei Shahzad Akbar Khan Jianfeng Ruan An Kang Xuguang Guo Qiang Zhou Wenrui Li Zheng Chen Yuemei Liang Pingchao Li Lei Zhang Tianxing Ji Clinical Laboratory Medicine Department The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510260China State Key Laboratories of Respiratory Diseases Guangdong-Hong Kong-Macao Joint Laboratory of Infectious Respiratory DiseaseGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou510535China Clinical Laboratory Medicine Department Dongguan Ninth People's HospitalDongguan523016China State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510120China Clinical Laboratory Medicine Department Maoming People's HospitalMaoming525000China Laboratory of Pathology Department of PathobiologyUniversity of Poonch Rawalakot Azad Kashmir Pakistan 12350Pakistan Hospital Infection-Control Department The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510260China Medical Examination Department The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510260China Department of Clinical Laboratory Medicine The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510140China Kidney Transplant Department The Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510260China Department of Organ Transplantation The Third Affiliated Hospital of Sun Yat-sen University510630China Guangzhou Key Laboratory for Clinical Rapid Diagnosis and Early Warning of Infectious Diseases KingMed School of Laboratory MedicineGuangzhou Medical UniversityGuangzhou511436China

Homologous booster,heterologous booster,and Omicron variants breakthrough infection(OBI)could improve the humoral immunity against Omicron *** concerning about memory B cells(MBCs)and T cells immunity against Omicron variants,features of long-term immunity,after booster and OBI,needs to be ***,comparative analysis demonstrate antibody and T cell immunity against ancestral strain,Delta and Omicron variants in Omicron breakthrough infected patients(OBIPs)are comparable to that in Ad5-nCoV boosted healthy volunteers(HVs),higher than that in inactivated vaccine(InV)boosted ***,memory B cells(MBCs)immunity against Omicron variants was highest in OBIPs,followed by Ad5-nCoV boosted and InV boosted *** and Ad5-nCoV boosted HVs have higher classical MBCs and activated MBCs,and lower naïve MBCs and atypical MBCs relative to both vaccine boosted ***,these data indicate Omicron breakthrough infection elicit higher MBCs and T cells against SARS-CoV-2 especially Omicron variants relative to homologous InV booster and heterologous Ad5-nCoV booster.

关键词： inactivated vaccine booster Ad5-nCoV booster Omicron variants breakthrough infection Memory immunity Binding antibody

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