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Comparative in-vitro analysis of different brands of paracetamol tablets available in Nepal

Journal of Coastal Life Medicine 2016年第8期4卷 645-648页

作者： Ganesh Man Singh Thakuri Kailash Kumar Yadav Rahul Rana Chhetri Department of Pharmaceutical Chemistry Doon(PG)Paramedical College and Hospital DehradunHemavati Nandan Bahuguna Garhwal UniversityPauri GarhwalUttarakhandIndia Department of Microbiology Tribhuwan UniversityKathmanduNepal Department of Pharmacy Pokhara UniversityPokharaKaskiNepal

Objective:To examine the physico-chemical parameters of commercially available local and multinational brands of paracetamol tablets in ***:Different five paracetamol brands were explored by testing various parameters according to standard *** studied parameters included weight variation,friability,disintegration,dissolution and *** limits of the official test were referenced from official guidelines of Indian Pharmacopoeia(IP)and British Pharmacopoeia(BP).All brands were tested according to their pharmacopoeial claim and methods for these tests were successfully conducted to find out their *** methods were economic and ***:Requirements of weight variation and friability value were complied by all *** minutes of disintegration time were also complied by all the brands according to the BP/IP recommendation for uncoated *** brands showed not less than 80%drug release in 45 min as per BP and not less than 85%in 30 min as per *** of each brand was found to be within the range of 95%-105%.The present findings suggested that about every paracetamol brand which was accessible in Nepali market encountering the IP/BP ***:Although the physico-chemical examinations such as weight variation,friability,disintegration,dissolution and assay were detected varying brand wise,but were found interior to defined *** an over-the-counter drug,the consumption of paracetamol is too ***,it is important for each brand to be genuine,good manufactured and well ***,additional exploration over the quality of paracetamol is compulsory for safe human consumption.

关键词： Acetaminophen Comparative study in-vitro analysis Paracetamol Physico-chemical test Quality control parameters

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Afterglow Nanoprobes for In-vitro Background-free Biomarker analysis

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Chemical Research in Chinese Universities 2024年第2期40卷 213-224页

作者： ZHENG Ting WANG Ying LI Xianming LI Chenghui WU Peng Analytical&Testing Centre State Key Laboratory of Hydraulics and Mountain River EngineeringSichuan UniversityChengdu610064P.R.China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang453007P.R.China Department of Rheumatology and Immunology West China HospitalSichuan UniversityChengdu610064P.R.China

Accurate detection of biomarkers is essential for disease *** the highly sensitive fluorescence probes are feasible for the above goal,it is typically interfered by the auto-fluorescence and light scattering of the biological *** afterglow system(consisting of photosensitizer,afterglow substrate and emitter)based on cascade photochemical reactions exhibits long-lived luminescence(seconds to hours),thus avoiding background *** the assistance of polymers,such as polystyrene microspheres,the photochemical afterglow systems have been transformed into homogeneous and water-soluble nanoparticles,and used for in-vitro biomarker ***,we summarized the principle,preparation and applications of these afterglow nanoparticles,and evaluated their performance in clinical sample testing by comparing with other nanoparticle-based ***,several problems and possible solutions of afterglow nanoparticle-based methods in biomarker determination were also mentioned.

关键词： Photochemical afterglow in-vitro analysis Background-free detection Biomarker

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