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Large-Scale Surface Modification of Decellularized Matrix with Erythrocyte Membrane for Promoting In situ Regeneration of heart Valve

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engineering 2024年第10期41卷 216-230页

作者： Yuqi Liu Pengning Fan Yin Xu Junwei Zhang Li Xu Jinsheng Li Shijie Wang Fei Li Si Chen Jiawei Shi Weihua Qiao Nianguo Dong Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

In situ regeneration is a promising strategy for constructing tissue engineering heart valves(TEHVs).Currently,the decellularized heart valve(DHV)is extensively employed as a TEHV ***,DHV exhibits limited blood compatibility and notable difficulties in endothelialization,resulting in thrombosis and graft *** red blood cell membrane(RBCM)exhibits excellent biocompatibility and prolonged circulation stability and is extensively applied in the camouflage of nanoparticles for drug delivery;however,there is no report on its application for large-scale modification of decellularized extracellular matrix(ECM).For the first time,we utilized a layer-by-layer assembling strategy to immobilize RBCM on the surface of DHV and construct an innovative TEHV *** findings demonstrated that the scaffold significantly improved the hemocompatibility of DHV by effectively preventing plasma protein adsorption,activated platelet adhesion,and erythrocyte aggregation,and induced macrophage polarization toward the M2 phenotype in ***,RBCM modification significantly enhanced the mechanical properties and enzymatic stability of *** rat models of subcutaneous embedding and abdominal aorta implantation showed that the scaffold regulated the polarization of macrophages into the anti-inflammatory and pro-modeling M2 phenotype and promoted endothelialization and ECM remodeling in the early stage without thrombosis and *** novel TEHV exhibits excellent performance and can overcome the limitations of commonly used clinical prostheses.

关键词： in situ tissue engineering heart valves Red blood cell membrane Endothelialization Hemocompatibility Immunomodulation

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