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Optimization-based conformal path planning for in situ bioprinting during complex skin defect repair

Bio-Design and Manufacturing 2025年第1期8卷 1-19,I0001页

作者： Wenxiang Zhao Chuxiong Hu Yunan Wang Shize Lin Ze Wang Tao Xu State Key Laboratory of Tribology in Advanced Equipment Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Beijing Key Laboratory of Precision and Ultra-Precision Manufacturing Equipment and Control Tsinghua UniversityBeijing 100084China Center for Bio-intelligent Manufacturing and Living Matter bioprinting Research Institute of Tsinghua University in ShenzhenTsinghua UniversityShenzhen 518057China

The global demand for effective skin injury treatments has prompted the exploration of tissue engineering *** three-dimensional(3D)bioprinting has shown promise,challenges persist with respect to achieving timely and compatible solutions to treat diverse skin *** situ bioprinting has emerged as a key new technology,since it reduces risks during the implantation of printed scaffolds and demonstrates superior therapeutic ***,maintaining printing fidelity during in situ bioprinting remains a critical challenge,particularly with respect to model layering and path *** study proposes a novel optimization-based conformal path planning strategy for in situ bioprinting-based repair of complex skin *** strategy employs constrained optimization to identify optimal waypoints on a point cloud-approximated curved surface,thereby ensuring a high degree of similarity between predesigned planar and surface-mapped 3D ***,this method is applicable for skin wound treatments,since it generates 3D-equidistant zigzag curves along surface tangents and enables multi-layer conformal path planning to facilitate the treatment of volumetric ***,the proposed algorithm was found to be a feasible and effective treatment in a murine back injury model as well as in other complex models,thereby showcasing its potential to guide in situ bioprinting,enhance bioprinting fidelity,and facilitate improvement of clinical outcomes.

关键词： in situ bioprinting Path planning Robot control Skin injury repair

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Robotic in situ bioprinting for cartilage tissue engineering

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International Journal of Extreme Manufacturing 2023年第3期5卷 118-142页

作者： Yaxin Wang Rúben F Pereira Chris Peach Boyang Huang Cian Vyas Paulo Bartolo Department of Mechanical Aerospace and Civil EngineeringUniversity of ManchesterManchester M139PLUnited Kingdom Instituto de Ciências Biomédicas Abel Salazar Universidade do Porto4050-313PortoPortugal Instituto de Investigacao e Inovaao em Saúde Universidade do Porto4200-135PortoPortugal Instituto de Engenharia Biomédica Universidade do Porto4200-135PortoPortugal Manchester University NHS Foundation Trust ManchesterUnited Kingdom Singapore Centre for 3D Printing School of Mechanical and Aerospace EngineeringNanyang Technological UniversitySingapore639798Singapore

Articular cartilage damage caused by trauma or degenerative pathologies such as osteoarthritis can result in significant pain,mobility issues,and *** surgical treatments have a limited capacity for efficacious cartilage repair,and long-term patient outcomes are not ***-dimensional bioprinting has been used to fabricate biochemical and biophysical environments that aim to recapitulate the native microenvironment and promote tissue ***,conventional in vitro bioprinting has limitations due to the challenges associated with the fabrication and implantation of bioprinted constructs and their integration with the native cartilage *** situ bioprinting is a novel strategy to directly deliver bioinks to the desired anatomical site and has the potential to overcome major shortcomings associated with conventional *** this review,we focus on the new frontier of robotic-assisted in situ bioprinting surgical systems for cartilage *** outline existing clinical approaches and the utilization of robotic-assisted surgical *** and robotic-assisted in situ bioprinting techniques including minimally invasive and non-invasive approaches are defined and ***,we discuss the challenges and potential future perspectives of in situ bioprinting for cartilage applications.

关键词： in situ bioprinting cartilage tissue engineering robotic in situ bioprinting minimally invasive surgery bioinks

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Minimally invasive bioprinting for in situ liver regeneration

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Bioactive Materials 2023年第8期26卷 465-477页

作者： Yueying Yang Zhengyang Yu Xiaohuan Lu Jiahao Dai Cheng Zhou Jing Yan Lin Wang Zheng Wang Jianfeng Zang School of Integrated Circuits and Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan430074PR China Research Center for Tissue Engineering and Regenerative Medicine Department of Gastrointestinal SurgeryWuhan Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022PR China Research Center for Tissue Engineering and Regenerative Medicine Department of Clinical LaboratoryWuhan Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022PR China State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan430074PR China

in situ bioprinting is promising for developing scaffolds directly on defect models in operating rooms,which provides a new strategy for in situ tissue ***,due to the limitation of existing in situ biofabrication technologies including printing depth and suitable bioinks,bioprinting scaffolds in deep dermal or extremity injuries remains a grand ***,we present an in vivo scaffold fabrication approach by minimally invasive bioprinting electroactive hydrogel scaffolds to promote in situ tissue *** minimally invasive bioprinting system consists of a ferromagnetic soft catheter robot for extrusion,a digital laparoscope for in situ monitoring,and a Veress needle for establishing a *** 3D reconstruction of the defects with computed tomography,electroactive hydrogel scaffolds are printed within partial liver resection of live rats,and in situ tissue regeneration is achieved by promoting the proliferation,migration,and differentiation of cells and maintaining liver function in vivo.

关键词： In vivo tissue regeneration in situ bioprinting Minimally invasive surgery Conductive hydrogel

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