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检索条件"主题词=In silico design"
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in silico design of anti-tumor mini-protein targeting MDM2
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Chinese Chemical Letters 2023年 第5期34卷 256-258页
作者: Jinghui Zhang Huixin Xu Baishi Wang Xuekai Zhang Lei Fu Yannan Li Guanzhao Wu Zitong Zhao Lu Liu Ting Yang Zheyu Zhang Jinbo Yang Tao Jiang Peiju Qiu Rilei Yu Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China Innovation Center for Marine Drug Screening&Evaluation Pilot National Laboratory for Marine Science and Technology(Qingdao) Qingdao 266003China Department of Biological Engineering College of Chemical and Biological EngineeringShandong University of Science and TechnologyQingdao 266590China
We designed a disulfide-crosslinked mini-protein with a two-helical topology consisting of L-and Damino acids,which was exceptionally stable in ***,we further used it as a scaffold to design mini-proteins targeting p5... 详细信息
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