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Abortifacient Potential of Aqueous Extract of Senna alata Leaves in Rats

Journal of Reproduction and Contraception 2010年第3期21卷 163-177页

作者： Yakubu MT Adeshina AO Oladiji AT Akanji MA Oloyede OB Jimoh GA Olatinwo AWO Afolayan AJ Phytomedicine ToxicologyReproductive and Developmental Biochemistry Research LaboratoryDepartment of BiochemistryUniversity of Ilorin Department of Obstetrics and Gynaecology University of Ilorin Centre for Phytomedicine Research Department of BotanyUniversity of Fort Hare

Objective To study the abortifacient activity of aqueous extract of Senna alata leaves in female Wistar *** Pregnant rats weighing 143.65 ± 13.11 g were completely randomized into 5 groups（A-E）.Rats in group A（negative control） were orally administered,once daily with 0.5 ml of distilled water on days 10-18 post-coitum while those in groups B,C,D,and E were treated exactly like the negative control except they received the same volume containing 2.85 mg/kg body weight of mifepristone（group B,reference drug）,250,500 and 1 000 mg/kg body weight of the extract respectively（groups C-E）.Results Phytochemical screening of the extract showed positive results for saponins（1.22%）,flavonoids（1.06%）,cardiac glycosides（0.20%）,cardenolides and dienolides（0.18%）,phenolics（0.44%） and alkaloids（0.52%）.Respiratory distress,salivation,diarrhoea,changes in the appearance of hair as well as maternal mortality were not observed at any time during the exposure period except in the mifepristone-treated animals where there was episode of diarrhoea and *** extract significantly reduced（P〈0.05） the number of life foetus,weight and survival ratio of the foetus,numbers of implantations and Corpora lutea,implantation index,progesterone,prolactin,estradiol,follicle stimulating and luteinizing hormones whereas the number of dead foetus,number and percentage of rats that aborted,percentage vaginal opening,resorption index,pre-and post-implantation losses increased *** addition,mifepristone-treated animals produced resorption index that compared well with the distilled water *** was also no dead or life foetus and serum progesterone concentration was increased in the animals treated with *** cases of abortion were accompanied with vaginal ***,the final weight of the rats increased significantly,the feed and water intake were not significantly altered in all the treatment *** weight of the uterus,uterine-body weight ratio,le

关键词： abortifacient estrogenicity implantation site leguminosae mifepristone pregnancy reproductive hormones Senna alata uterogenicity uterus

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Anordrin(抗孕—53)对小鼠子宫着床点发育的影响

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中华生殖与避孕杂志 1986年第4NO.03NO.02NO.01期 31-33页

作者：李恕香袁瑶上海市计划生育科学研究所

本工作试图了解Anordrin 的抗孕作用机理。交配后6天,正常着床的小鼠,选入本实验。实验组分别在交配后第6天、6～7天、6～8天,灌服不同剂量的Anordrin。对照组不灌药。分别在交配后7天、8天、9天,处死两组动物,取全部子宫固定、包埋通... 详细信息

本工作试图了解Anordrin 的抗孕作用机理。交配后6天,正常着床的小鼠,选入本实验。实验组分别在交配后第6天、6～7天、6～8天,灌服不同剂量的Anordrin。对照组不灌药。分别在交配后7天、8天、9天,处死两组动物,取全部子宫固定、包埋通过着床点连续切片,光镜观察。结果孕后第6天单次给药,对着床点发育无影响,第6～7天连续2次给药者,部分着床点发生病变;6～8天连续3次给药,则几乎全部着床点发生病变。药物主要损伤绒毛、绒毛膜及胎盘组织。

关键词： Anordrin Anti-pregnancy mechanism implantation site Mice

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Expression of S100A10 gene and its regulation by sex hormones in mouse uterus

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Progress in Natural Science:Materials International 2005年第10期 40-45页

作者： CHEN Zhiqiang, LIU Jing, LI Feixue, SUN Xiaoyang, ZHANG Huaiyun and WANG Yanling (State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China) State Key Laboratory of Reproductive Biology，Institute of Zoology，Chinese Academy of Sciences，Beijing 100080，China College of Animal Science and Technology，Hunan Agricultural University，Changsha 410128，China State Key Laboratory of Reproductive Biology，Institute of Zoology，Chinese Academy of Sciences，Beijing 100080，China College of Animal Science and Technology，Hunan Agricultural University，Changsha 410128，China

S100A10 belongs to the S100 calcium binding protein superfamily, and functions as one of the mediators of calcium-de-pendent signaling pathway. Recently, S100A10 gene was proved to be significantly up-regulated at the implantation site. In the present study, semi-quantitative reverse transcriptase-polymerase chain reaction and in situ hybridization are used to investigate the tissue-specificity of S100A10 expression and the expression pattern of S100A10 in the uteri during the estrous cycle and pregnancy. Meanwhile, the regulation of S100A10 expression by sex steroid hormones is studied in ovariectomized mice. The results show that S100A10 could be detected in various kinds of tissues, with relatively high expression in reproductive tracts including ovary, uterus, teslis and epididymis. During pregnancy, the expression of S100A10 in the uteri is significantly up-regulated on the 4th day. The transcript is strongly detected in endometrial stromal cells and weakly in luminal epithelium cells at the implantation site,but almost not at the inter-implantation site. From gestational day 5 till labor, S100A10 mRNA maintains a certain level in both uteri and placentae. During the estrous cycle, expression of S100A10 is up-regulated in the uteri at proestrus and estrus. Estradiol significantly induces the expression of S100A10, while progesterone can abolish the effect of estradiol. The data suggests that S100A10 may be involved in preventing luminal epithelial cells from over-apoptosis, inducing proliferation and decidualization of stromal cells during implantation, and responding to reproductive stress triggered by copulation.

关键词： S100A10 uterus implantation site estrous cycle pregnancy sex steroid hormone.

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促黄体素释放激素类似物(LH-RH-A)对妊娠大鼠子宫代谢的直接作用

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Current Zoology 1984年第2期30卷 121-125页

作者：刘以训朱洪华张致一中国科学院动物研究所内分泌研究室

本实验结果表明,胚泡着床点对;H-尿嘧啶和;H-亮氨酸的摄取明显高于非着床点子宫部位。LH-RH-A可显著抑制胚泡着床点对这两种同位素的摄取;且对非着床子宫组织也有抑制作用,但抑制程度较弱。进一步证实,着床的胚泡确能产生一种或几种因子... 详细信息

本实验结果表明,胚泡着床点对;H-尿嘧啶和;H-亮氨酸的摄取明显高于非着床点子宫部位。LH-RH-A可显著抑制胚泡着床点对这两种同位素的摄取;且对非着床子宫组织也有抑制作用,但抑制程度较弱。进一步证实,着床的胚泡确能产生一种或几种因子,对子宫内膜的分化起重要作用;同时证实,LH-RH-A可通过对RNA和蛋白质合成的抑制作用而直接影响妊娠大鼠子宫的代谢,对胚泡着床点部位的影响尤为明显。

关键词： LH-RH-A Rat implantation site Non-implantation segment Incorporation 3H-uridine 3H-leucine Inhibitory effect.

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